The potentiation of analgesic activity of paracetamol plus morphine involves the serotonergic system in rat brain

Sandrini, Maurizio; Vitale, Giovanni; Ottani, Alessandra; Pini, Luigi Alberto

doi:10.1007/s000110050434

Cited by 28 publications

(14 citation statements)

References 44 publications

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“…The drugs were administered twice a day, at 8:00 and 18:00. The doses of paracetamol and morphine were chosen on the basis of previous dose-response experiments carried out under identical experimental conditions [10,20]. The animals were subjected to the hot-plate test 30 min after the fi rst drug administration on days 1, 3 and 7, each animal only being tested once.…”

Section: Drug Treatmentmentioning

confidence: 99%

Effect of acute and repeated administration of paracetamol on opioidergic and serotonergic systems in rats

et al. 2007

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Section: Drug Treatmentmentioning

confidence: 99%

Effect of acute and repeated administration of paracetamol on opioidergic and serotonergic systems in rats

et al. 2007

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“…Reports on the interaction and possible use of analgesic combinations in various painful conditions have been published (Salazer et al, 1995;Sandrini et al, 1998Sandrini et al, , 1999LopezMunoz et al, 2004). Thus, the focus of this study was to examine the anti-hyperalgesic efficacy of a new selective COX-2 inhibitor, etoricoxib and atypical opioid, tramadol during SCI-induced mechanical hyperalgesia and secondly a quantitative evaluation of anti-hyperalgesic interaction between etoricoxib and tramadol.…”

Section: Discussionmentioning

confidence: 95%

Analysis of interaction between etoricoxib and tramadol against mechanical hyperalgesia of spinal cord injury in rats

2006

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“…Among them, 5-HT 1A somatodendritic receptors [92], mainly in the dorsal raphe nucleus and the magnus raphe nucleus, control serotonin activity in the brainstem. There is no evidence of a direct interaction of paracetamol with 5-HT 1A receptor [78,93].…”

Section: Paracetamolmentioning

confidence: 87%

The Role of 5-HT1A Receptors in Research Strategy for Extensive Pain Treatment

Micó¹,

Berrocoso²,

Ortega-Álvaro³

et al. 2006

CTMC

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In the last few years, there has been a great increase in our understanding of pain mechanisms. Given the complexity of the mechanisms involved in pain modulation, it is surprising that the pharmacological control of pain through the application of relatively simple analgesics can be effective. Nevertheless, the application of single analgesics is not always effective in diverse painful conditions such as chronic pain syndromes. In these circumstances, we can take advantage of the complexity of pain regulation and try to identify new targets in these intricate processes. It is becoming clear that the combination of different mechanisms, which improves efficacy with reduced toxicity, is necessary for the reliable pharmacotherapy of pain, and is at the forefront in the search for better analgesics. Serotonin is involved at multiple levels in the regulation of nociception. In particular, the raphe nuclei may play a crucial role in integrating the nociceptive and affective information through descending projections to the spinal cord and ascending projections to the forebrain. In these nuclei, 5-HT1A receptors function as somatodendritic autoreceptors controlling the release of serotonin in terminal areas. Different studies have shown that, by preventing this inhibitory control of serotonin release, it is possible to enhance the analgesic effect of drugs that increase serotonin levels (i.e. antidepressants, opiates, and non-steroidal anti-inflammatory drugs) by facilitating descending, and also ascending, pathways involved in pain modulation. Therefore, 5-HT1A receptors may be used as a new target in the search for new pharmacological approaches in the augmentation of analgesia.

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The potentiation of analgesic activity of paracetamol plus morphine involves the serotonergic system in rat brain

Abstract: Subactive doses of paracetamol and morphine exert an analgesic effect when given in combination in the rat and indicate an involvement of both serotonergic and opiatergic systems.

Cited by 28 publications

References 44 publications

Effect of acute and repeated administration of paracetamol on opioidergic and serotonergic systems in rats

Effect of acute and repeated administration of paracetamol on opioidergic and serotonergic systems in rats

Analysis of interaction between etoricoxib and tramadol against mechanical hyperalgesia of spinal cord injury in rats

The Role of 5-HT1A Receptors in Research Strategy for Extensive Pain Treatment

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