The Power of Biocatalysts for Highly Selective and Efficient Phosphorylation Reactions

Wohlgemuth, Roland

doi:10.3390/catal12111436

Cited by 8 publications

(4 citation statements)

References 200 publications

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“…Phosphorylated molecules play critical roles in metabolism, signaling, and a wide array of other biological processes. − Classes of phosphorylating enzymes include phosphotransferases, phosphorylases, phosphohydrolases, and phosphomutases . Phosphopentomutases (PPMs) catalyze the interconversion between ribose-5-phosphate and ribose-1-phosphate and are important in the bacterial nucleoside salvage pathway .…”

Section: Functional Group Manipulationmentioning

confidence: 99%

“…89−91 Classes of phosphorylating enzymes include phosphotransferases, phosphorylases, phosphohydrolases, and phosphomutases. 92 Phosphopentomutases (PPMs) catalyze the interconversion between ribose-5-phosphate and ribose-1-phosphate and are important in the bacterial nucleoside salvage pathway. 93 Recently, a panel of PPMs was examined to identify an enzyme capable of converting 78 to 79 (Scheme 15) via transfer of a phosphate group from a primary hydroxyl to a more sterically encumbered secondary hydroxyl.…”

Section: Alcohol Acylationmentioning

confidence: 99%

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Non-Native Site-Selective Enzyme Catalysis

Mondal,

Snodgrass,

Gomez

et al. 2023

Chem. Rev.

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The ability to site-selectively modify equivalent functional groups in a molecule has the potential to streamline syntheses and increase product yields by lowering step counts. Enzymes catalyze site-selective transformations throughout primary and secondary metabolism, but leveraging this capability for non-native substrates and reactions requires a detailed understanding of the potential and limitations of enzyme catalysis and how these bounds can be extended by protein engineering. In this review, we discuss representative examples of site-selective enzyme catalysis involving functional group manipulation and C–H bond functionalization. We include illustrative examples of native catalysis, but our focus is on cases involving non-native substrates and reactions often using engineered enzymes. We then discuss the use of these enzymes for chemoenzymatic transformations and target-oriented synthesis and conclude with a survey of tools and techniques that could expand the scope of non-native site-selective enzyme catalysis.

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Section: Functional Group Manipulationmentioning

confidence: 99%

Section: Alcohol Acylationmentioning

confidence: 99%

Non-Native Site-Selective Enzyme Catalysis

Mondal,

Snodgrass,

Gomez

et al. 2023

Chem. Rev.

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show abstract

“…The implementation of a biocatalytic route in a productive process might demand specificity related to the equipment and a considerable economic investment. Nevertheless, the operating conditions indicate that biocatalysis is a promising alternative for the synthesis of fine chemicals, especially those related to the pharmaceutical sector, where productivity and selectivity constitute key factors [180]. Additionally, there is a great variety of enzymes and cell systems available for each compound, which contributes to avoiding subsequent purification stages that are common in the existing chemical processes.…”

Section: Biocatalysis As the Basis For Producing Specialty And Fine C...mentioning

confidence: 99%

Sustainable Biorefineries Based on Catalytic Biomass Conversion: A Review

2023

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Biorefineries have been profiled as potential alternatives to increase biomass use at the industrial level. However, more efforts are required to improve the sustainability of these facilities through process improvement and product portfolio increase. The catalytic conversion of biomass to chemicals and energy vectors is one of the most studied research lines today. The open literature has described catalytic pathways for producing biofuels and platform molecules using this renewable resource. Nevertheless, few literature reviews have aimed to analyze the role of the catalytic conversion of biomass in biorefineries while considering the following items: (i) biocatalysis, (ii) carbon dioxide conversion, (iii) design based on catalytic biomass upgrading, and (iv) sustainability metrics. This paper reviews several processes where catalysis has been applied to improve yields and conversion to elucidate the potential of this research field to boost biomass implementation in different productive sectors. This paper provides an overview of the catalytic conversion of biomass into a series of biofuels and high-value-added products, involving key topics related to catalyst performance, use, applications, and recent trends. In addition, several research gaps and ideas are highlighted based on previous studies. In conclusion, the catalytic conversion of biomass has the potential to increase biorefineries’ sustainability. Nevertheless, more studies focused on (i) the production of new catalysts using renewable resources, (ii) the techno-economic and environmental assessment of processes involving catalysis, and (iii) the influence of involving biomass valorization via heterogeneous catalysis in existing facilities are required to obtain a real understanding of catalytic upgrades’ benefits.

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“…[89][90][91] Classes of phosphorylating enzymes include phosphotransferases, phosphorylases, phosphohydrolases, and phosphomutases. 92 Purine nucleoside phosphorylases (PNPs) catalyze the reaction between a purine nucleoside and phosphate to generate the free nucleobase and ribose-1-phosphate. 93 Recently, a panel of PNPs was examined to identify an enzyme capable of converting 78 to 79 via transfer of a phosphate group from a primary hydroxyl to a more sterically encumbered secondary hydroxyl.…”

Section: Hydroxyl Group Phosphorylationmentioning

confidence: 99%

Non-Native Site-Selective Enzyme Catalysis

Mondal

Snodgrass

Gomez

et al. 2023

Preprint

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The ability to a site-selectively modify equivalent functional groups in a molecule has the potential to streamline syntheses and increase product yields by lowering step counts. Enzymes catalyze site-selective transformations throughout primary and secondary metabolism, but leveraging this capability for non-native substrates and reactions requires a detailed understanding of the potential and limitations of enzyme catalysis and how these bounds can be extended by protein engineering. In this review, we discuss representative examples of site-selective enzyme catalysis involving functional group manipulation and C-H bond functionalization. We include illustrative examples of native catalysis, but our focus is on cases involving non-native substrates and reactions often using engineered enzymes. We then discuss the use of these enzymes for chemoenzymatic transformations and target-oriented synthesis and conclude with a survey of tools and techniques that could expand the scope of non-native site-selective enzyme catalysis.

show abstract

The Power of Biocatalysts for Highly Selective and Efficient Phosphorylation Reactions

Cited by 8 publications

References 200 publications

Non-Native Site-Selective Enzyme Catalysis

Non-Native Site-Selective Enzyme Catalysis

Sustainable Biorefineries Based on Catalytic Biomass Conversion: A Review

Non-Native Site-Selective Enzyme Catalysis

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