The powerful microbubble: from bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond

Feinstein, Steven B.

doi:10.1152/ajpheart.00134.2004

Cited by 206 publications

(159 citation statements)

References 105 publications

Supporting

Mentioning

153

Contrasting

Unclassified

Order By: Relevance

“…No data have been reported in vivo. Finally, contrast-enhanced ultrasound (microbubbles) provides high-quality images of human plaque microvessels in carotid lesions 70 and may also facilitate imaging neovessels in coronary lesions. 71 Despite these preliminary results, multiple limitations of each of these techniques oriented the field toward molecular imaging.…”

Section: Neovascularization and Imagingmentioning

confidence: 99%

Neovascularization in Human Atherosclerosis

Moreno¹,

Purushothaman²,

Zias³

et al. 2006

CMM

247

229

View full text Add to dashboard Cite

Section: Neovascularization and Imagingmentioning

confidence: 99%

Neovascularization in Human Atherosclerosis

Moreno¹,

Purushothaman²,

Zias³

et al. 2006

CMM

247

229

View full text Add to dashboard Cite

“…A large number of techniques are available to evaluate blood flow in tissue. Among the most widely used are: venous occlusion plethysmography, microsphere injection, 15 O PET, sestamibi 99m Te SPECT, 133 Xe SPECT, first-pass iodinated contrast CT scan, first-pass Gd-chelates MRI and microbubbleassisted ultrasound (74)(75)(76)(77).…”

Section: Nmr Determination Of Skeletal Muscle Perfusion: a Key-role Fmentioning

confidence: 99%

Muscle blood flow and oxygenation measured by NMR imaging and spectroscopy

et al. 2006

View full text Add to dashboard Cite

Tissue perfusion and oxygenation in many organs can be evaluated by various NMR techniques. This review focuses on the specificities, limitations and adaptations of the NMR tools available to investigate perfusion and oxygenation in the skeletal muscle of humans and animal models. A description of how they may be used simultaneously is provided as well.1 H NMR spectroscopy of myoglobin (Mb) monitors intramyocytic oxygenation. It measures the level of deoxy-Mb, from which Mb concentration, Mb desaturation/resaturation rates, muscle oxygenation changes and intracellular partial oxygen pressure (pO 2 ) can be calculated. Positive and negative blood oxygen level-dependent (BOLD) contrasts exist in skeletal muscle. BOLD contrasts primarily reflect changes in capillary-venous oxygenation, but are also directly or indirectly dependent on muscle blood volume, perfusion, vascular network architecture and angulation, relative to the main magnetic field. Arterial spin labelling (ASL) techniques, having high spatial and temporal resolution, are the methods of choice to quantify and map skeletal muscle perfusion non-invasively. Limitations of ASL are poor contrast-to-noise ratio and sensitivity to movement; however, with the introduction of specific adaptations, it has been proven possible to measure skeletal muscle perfusion at both rest and during exercise. The possibility of combining these NMR measurements with others into a single dynamic protocol is most interesting. The 'multiparametric functional (mpf) NMR' concept can be extended to include the evaluation of muscle energy metabolism simultaneously with 31 P NMR or with lactate double quantum filtered 1 H NMR spectroscopy, an approach which would make NMR an exceptional tool for non-invasive investigations of integrative physiology and biochemistry in skeletal muscle in vivo.

show abstract

“…75 Subsequently, these phagocytosed microbubbles generate characteristic echogenic features that can be used to identify their distribution within the plaque with realtime intravascular ultrasonography. [76][77][78] Vavuranakis et al 76 used contrast enhancement with microbubbles in both animal and human models to detect blood flow into the coronary lumen and perivascular flow, as part of contrast-enhanced sonographic images. 79 In a porcine model, 11 regions of interest within the left anterior descending coronary arteries and left circumflex arteries, including perivascular structures, were compared with corresponding gray-scale intravascular sonography levels before and after the injection of SonoVue contrast (0.06 mL/kg; Bracco Diagnostics, Princeton, New Jersey).…”

Section: Microbubblesmentioning

confidence: 99%

Intravascular Ultrasound: Principles and Cerebrovascular Applications

Zacharatos¹,

Hassan²,

Qureshi³

2010

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

SUMMARY: Intravascular sonography is a valuable tool for the morphologic assessment of coronary atherosclerosis and the effect of pharmacologic and nonpharmacologic interventions on the progression or stabilization of atherosclerosis. An analysis of the different modes, applications, and limitations is provided on the basis of review of existing data from multiple clinical case studies, trials, and mechanistic studies. Intravascular sonography has been used to assess the outcomes of different percutaneous interventions, including angioplasty and stent implantation, and to provide detailed characterization of atherosclerotic lesions, aneurysms, and dissections within the cerebrovascular circulation. Evolution of intravascular sonographic technology has led to the development of more sophisticated diagnostic tools such as color-flow, virtual histology, and integrated backscatter intravascular sonography. The technologic advancement in intravascular sonography has the potential of providing more accurate information prior, during, and after a medical or endovascular intervention. Continued assessment of this diagnostic technique in both the intracranial and extracranial circulation will lead to increased use in clinical practice with the intent to improve outcomes.ABBREVIATIONS: CI ϭ confidence interval; EEL ϭ external elastic lamina; O.D. ϭ outer diameter C urrently there are 3 types of sonography used to assess the extracranial and the intracranial circulation: 1) transcranial Doppler, 2) B-mode sonography, and 3) intravascular sonography (Table). The morphologic appearance of the intra-arterial and intravenous circulation can now be visualized by using intravascular sonography, which has become a commonly used diagnostic technique for randomized clinical trials assessing coronary plaque progression and regression. With excellent resolution, intravascular sonography provides cross-sectional images of both the arterial wall and lumen and identifies intimal flaps and irregularities, and the composition and extent of the atherosclerotic plaque.2-6 Evolution of the intravascular sonography technology has led to the development of more sophisticated diagnostic tools such as colorflow, virtual histology, and integrated backscatter intravascular sonography. 7 The successful application of conventional (gray-scale) intravascular sonography in the coronary arteries has led to its application within the extracranial and intracranial arteries. Recently, intravascular sonography has also been used to identify and characterize carotid artery aneurysm, dissection, and thrombus. 8 Intravascular sonography has been used successfully to assist in making measurements before and after percutaneous transluminal balloon angioplasty and stent placement, with emphasis on the identification of stent underexpansion, poor apposition, subacute stent thrombosis, and plaque protrusion.9,10 Real-time dynamic intravascular sonography of the cervical common carotid artery and internal carotid artery can detect defects that are not readily appar...

show abstract

The powerful microbubble: from bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond

Cited by 206 publications

References 105 publications

Neovascularization in Human Atherosclerosis

Neovascularization in Human Atherosclerosis

Muscle blood flow and oxygenation measured by NMR imaging and spectroscopy

Intravascular Ultrasound: Principles and Cerebrovascular Applications

Contact Info

Product

Resources

About