The PPARα and PPARγ Epigenetic Landscape in Cancer and Immune and Metabolic Disorders

Porcuna, Jesús; Martínez, Jorge Mínguez; Ricote, Mercedes

doi:10.3390/ijms221910573

Cited by 38 publications

(19 citation statements)

References 218 publications

(269 reference statements)

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“…PPARs are ligand-induced nuclear receptors and are involved in several peroxide proliferation reactions, including metabolic and apoptotic pathways related to lipid metabolism. PPARs are generally highly expressed on tumor cells, and their expression is dependent on several factors such as PPAR subtype and type and stage of the tumor 122 . When activated by ligands such as AA derivatives, PUFA, and non-steroidal anti-inflammatory drugs (NSAIDs), PPARs receptors enter the nucleus to regulate the transcription of genes encoding enzymes of lipid metabolism, such as FABP, CPT1, and SCD1, and peroxisome genes related to lipid peroxidation 123 .…”

Section: Abnormal Regulation Of Lipid Metabolismmentioning

confidence: 99%

The role of lipid metabolic reprogramming in tumor microenvironment

Yang¹,

Wang²,

Song³

et al. 2023

Theranostics

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Metabolic reprogramming is one of the most important hallmarks of malignant tumors. Specifically, lipid metabolic reprogramming has marked impacts on cancer progression and therapeutic response by remodeling the tumor microenvironment (TME). In the past few decades, immunotherapy has revolutionized the treatment landscape for advanced cancers. Lipid metabolic reprogramming plays pivotal role in regulating the immune microenvironment and response to cancer immunotherapy. Here, we systematically reviewed the characteristics, mechanism, and role of lipid metabolic reprogramming in tumor and immune cells in the TME, appraised the effects of various cell death modes (specifically ferroptosis) on lipid metabolism, and summarized the antitumor therapies targeting lipid metabolism. Overall, lipid metabolic reprogramming has profound effects on cancer immunotherapy by regulating the immune microenvironment; therefore, targeting lipid metabolic reprogramming may lead to the development of innovative clinical applications including sensitizing immunotherapy.

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Section: Abnormal Regulation Of Lipid Metabolismmentioning

confidence: 99%

The role of lipid metabolic reprogramming in tumor microenvironment

Yang¹,

Wang²,

Song³

et al. 2023

Theranostics

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“…40 We found further evidence for lipid-related processes in cluster 6 including enrichment for the peroxisome proliferator-activated receptor pathway (KEGG_PPAR_SIGNALING_PATHWAY), which is critical to metabolic and lipid-related processes and has also been found to regulate and be regulated by epigenetic processes including by DNA methyltransferases. 42 Inspection of low-affinity clusters was also informative. Cluster 2 was enriched for KEGG_PRIMARY_ IMMUNODEFICIENCY and KEGG_HEMATOPOIETIC_CELL_LINEAGE.…”

Section: Analysis Of Biological Resultsmentioning

confidence: 99%

Bayesian Multi-View Clustering given complex inter-view structure

Shapiro

Battle

2022

F1000Res

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Multi-view datasets are becoming increasingly prevalent. These datasets consist of different modalities that provide complementary characterizations of the same underlying system. They can include heterogeneous types of information with complex relationships, varying degrees of missingness, and assorted sample sizes, as is often the case in multi-omic biological studies. Clustering multi-view data allows us to leverage different modalities to infer underlying systematic structure, but most existing approaches are limited to contexts in which entities are the same across views or have clear one-to-one relationships across data types with a common sample size. Many methods also make strong assumptions about the similarities of clusterings across views. We propose a Bayesian multi-view clustering approach (BMVC) which can handle the realities of multi-view datasets that often have complex relationships and diverse structure. BMVC incorporates known and complex many-to-many relationships between entities via a probabilistic graphical model that enables the joint inference of clusterings specific to each view, but where each view informs the others. Additionally, BMVC estimates the strength of the relationships between each pair of views, thus moderating the degree to which it imposes dependence constraints. We benchmarked BMVC on simulated data to show that it accurately estimates varying degrees of inter-view dependence when inter-view relationships are not limited to one-to-one correspondence. Next, we demonstrated its ability to capture visually interpretable inter-view structure in a public health survey of individuals and households in Puerto Rico following Hurricane Maria. Finally, we showed that BMVC clusters integrate the complex relationships between multi-omic profiles of breast cancer patient data, improving the biological homogeneity of clusters and elucidating hypotheses for functional biological mechanisms. We found that BMVC leverages complex inter-view structure to produce higher quality clusters than those generated by standard approaches. We also showed that BMVC is a valuable tool for real-world discovery and hypothesis generation.

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“… 73 , 84 , 95 , 96 All of this demonstrated that SCFAs regulate the epigenome by modifying HDACs in addition to acting as signaling molecules. 17 , 96 - 100 …”

Section: Scfas-metabolic Pathologies Axismentioning

confidence: 99%

The Implication of Short-Chain Fatty Acids in Obesity and Diabetes

et al. 2023

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Evidence indicates that short-chain fatty acids (SCFAs) generated from the gut microbiota play crucial roles in host metabolism. They contribute to metabolic regulation and energy acquisition of the host by influencing the development of metabolic disorders. This review aims to synthesize recent advances from the literature to investigate the implication of SCFAs in the modulation of obesity and diabetes pathologies. For a better understanding of the relationships between SCFAs and host metabolism, we need to answer some questions: What is the biochemistry of SCFAs, and how they are generated by gut microbiota? What are the bacteria producing of SCFAs and from which routes? How SCFAs are absorbed and transported in the gut by different mechanisms and receptors? How SCFAs involved in obesity and diabetes pathologies?

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The PPARα and PPARγ Epigenetic Landscape in Cancer and Immune and Metabolic Disorders

Cited by 38 publications

References 218 publications

The role of lipid metabolic reprogramming in tumor microenvironment

The role of lipid metabolic reprogramming in tumor microenvironment

Bayesian Multi-View Clustering given complex inter-view structure

The Implication of Short-Chain Fatty Acids in Obesity and Diabetes

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