Abstract:The present paper provides a numerical study that leads to the proper selection of a working fluid for use in low-temperature organic Rankine cycle (ORC) applications. This selection is not only based on the provision of best efficiency but also to comply with global warming potential (GWP) regulations. For that purpose, different pure organic working fluids, including R245fa, R236fa, R123, R600a, R134a, and R1234yf as well as zeotropic mixture R245fa/R600a, are selected. The investigation is conducted on a single stage radial inflow turbo-expander, which was originally used in the Sundstrand Power Systems T-100 Multipurpose Small Power Unit. The commercial package ANSYS-CFX (version 16.0) was used to perform the numerical study using 3D Reynolds-Averaged Navier-Stokes (RANS) simulations. Peng-Robinson equation of state is adopted in the finite-volume solver ANSYS-CFX to determine the real-gas properties. The obtained results show that, while the use of R134a and R1234yf provides the best efficiency of all the working fluids under investigation, the latter is best selected for its comparatively low global warming effects.