The Pre-Clinical Animal Model in the Translational Research of Interventional Cardiology

Suzuki, Yoriyasu; Yeung, Alan C.; Ikeno, Fumiaki

doi:10.1016/j.jcin.2009.03.004

Cited by 53 publications

(38 citation statements)

References 86 publications

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“…Scientific studies typically begin at "the bench" with basic research, before progressing to the clinical level (Takata & Kato, 1996;Y. Suzuki et al, 2008;Chorro et al, 2009;Y Suzuki et al, 2009). The spontaneously hypertensive rat (SHR) and the hereditary obese mice, ob/ob mice, are among the very few excellent animal models that excellently mimic the respective human disease, and are therefore, very useful for translational research into the common human diseases, HTN and obesity (Nakao et al, 2009).…”

Section: Models In Cardiovascular Researchmentioning

confidence: 99%

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Raji

Mugabo

Obikeze

2012

Journal of Ethnopharmacology

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Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats I. A. RAJITulbaghia violacea Harv. (Alliaceae) is a small bulbous herb which belongs to the family, Alliaceae, most commonly associated with onions and garlic. In South Africa (SA), this herb has been traditionally used in the treatment of various ailments, including fever, colds, asthma, paralysis, hypertension (HTN) and stomach problems. The aim of this study was to evaluate the effect of methanol leaf extracts (MLE) of T. violacea on the blood pressure (BP) and heart rate (HR) in anaesthetized male spontaneously hypertensive rats; and to find out the mechanism(s) by which it acts.The MLE of T. violacea (5 -150 mg/kg), angiotensin I (ang I, 3.1 -100 µg/kg), captopril (10 mg/kg), angiotensin II (ang II, 3.1 -50 µg/kg), losartan (30 mg/kg), phenylephrine T. violacea (60 mg/kg) and captopril (10 mg/kg) were injected intraperitoneally into iii some SHR for 21 days to investigate the chronic effect of these agents on plasma levels of aldosterone. The mean change, the mean of the individual percentage changes and the percentage difference (in mean) observed with each intervention was calculated and statistically analyzed using the Student's t test for significant difference (p < 0.05). The Microsoft Excel software was used for statistical analysis.T. violacea significantly (p < 0.05) reduced the systolic, diastolic, and mean arterial BP;and HR dose-dependently. In a dose-dependent manner, ang I, ang II, phenylephrine significantly (p < 0.05) increased the BP, while propranolol, muscarine and atropine reduced the BP. The increases in BP due to dobutamine were not dose-dependent. In a dose dependent manner, phenylephrine and propranolol reduced the HR, while dobutamine increased the HR. The effect of ang I, ang II, muscarine and atropine on HR were not dose-dependent; with both increases as well as decreases observed with ang I, and II and atropine, while decreases were seen with muscarine. Captopril produced significant (p < 0.05) reduction in BP which were not associated with any change in HR.The co-infusion of ang I with the MLE produced significant (p < 0.05) reduction in BP, which were not associated with significant changes in HR. The co-infusion of ang II with the MLE did not produce any significant changes in BP or HR when compared to the infusion of the standard drug alone. The co-infusion of phenylephrine with the MLE did

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Section: Models In Cardiovascular Researchmentioning

confidence: 99%

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Raji

Mugabo

Obikeze

2012

Journal of Ethnopharmacology

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“…One must question whether such data from animals caused drugs for DESs that would have been effective for humans to be discarded [298,299]. I encountered no calculation of PPV and NPV of animal models for stent assessment despite many proclamations of the predictive value of such models [263,265,300,301]. For example, Virmani et al: "It can be argued that insufficient preclinical testing may have led to the recent failures of actinomycin-D (European Society of Cardiology Congress 2002, unpublished data) and the paclitaxel derivate (QP2 or 7-hexanoyltaxol) eluting polymer stents in de novo and restenotic lesions.…”

Section: Palmaz Et Al First Employed Stents In Peripheral Arteries Imentioning

confidence: 99%

“…Pre-clinical studies using animal models play a very important role in the evaluation of efficacy and safety of new medical devices before their use in human clinical studies" [301]. Suzuki et al state again in 2011: "Although no animal model can fully replicate the complexity of human pathological conditions, animal models are key for the evaluation of mechanisms of disease and testing of diagnostic technologies and interventions" [300]. Words like "evaluation," when used in the context of the above offer nothing of value when analyzing the predictive value of animal models.…”

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confidence: 99%

A Discussion of the Role of Complex Evolved Systems in the Development of Invasive Cardiovascular Interventions as Illustrated by the Blalock- Taussig Shunt and Intra-Arterial Stents

Greek¹

2014

Biol Syst Open Access

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Scientific disciplines normally thought of as outside the sphere of medical science have experienced advances over the past twenty years that currently have profound implications for medical care and medical research. Evolutionary and developmental biology, complexity and chaos science, along with the Human Genome Project and spinoff projects, have dramatically altered our understanding of how the human body functions and what can be expected from research methods like animal modeling. In this article, I summarize these advances and examine one historical medical development, the Blalock-Taussig shunt, in order to ascertain whether historically accepted representations of this development are consistent with current knowledge. I also examine an ongoing technology-intra-arterial stent development-to compare human data to the known animal data and place this comparison in the context of the aforementioned advances.

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“…Despite the fact that invasive/non-invasive therapies of cardiovascular disease have advanced dramatically over the last two decades, heart disease is still a major cause of morbidity and mortality in industrialized countries [1,2]. Many research groups focus on the development of cardiomyogenic models to dissect how damaged heart muscle may be repaired.…”

Section: Introductionmentioning

confidence: 99%

“…Although there are several cardiomyogenic in vitro and in vivo models available including cell cultures [1], the testing of a new compound in high throughput test systems relies on the best option for analyzing the effects on proteins, the specificity and efficacy of a drug and also the toxicity caused by a drug. Each drug is tested on cardiomyocytes for analyzing the effect on heart activity.…”

Section: Introductionmentioning

confidence: 99%

Development of an In vitro Cultivated, Spontaneously and Long-term Contracting 3D Heart Model as a Robust Test System

Grunow¹,

Schmidt²,

Klinger³

et al. 2017

J Cell Sci Ther

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The study deals with an in vitro heart model established from rainbow trout larvae. This model is based on spontaneously contracting cell aggregates (SCC) exhibiting fully developed cardiomyocytes connected via gap junctions and building up a functional syncytium with a pacemaker centre. The cellular structure and the electrophysiological properties of the cardiomyocytes resembled that of human heart cells. It was possible to generate more than one SCC from one fish larva. The SCCs contracted spontaneously over several weeks with a stable contracting frequency similar to human heart. Our analysis supports the use of this model as a high-throughput test system in cardiac research with the potential to complement and reduce animal testing.

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The Pre-Clinical Animal Model in the Translational Research of Interventional Cardiology

Cited by 53 publications

References 86 publications

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

A Discussion of the Role of Complex Evolved Systems in the Development of Invasive Cardiovascular Interventions as Illustrated by the Blalock- Taussig Shunt and Intra-Arterial Stents

Development of an In vitro Cultivated, Spontaneously and Long-term Contracting 3D Heart Model as a Robust Test System

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