The pre/parasubiculum: a hippocampal hub for scene-based cognition?

Dalton, Marshall A.; Maguire, Eleanor A.

doi:10.1016/j.cobeha.2017.06.001

Cited by 78 publications

(93 citation statements)

References 62 publications

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“…Navigation is typically associated with the posterior hippocampus (Maguire et al, 2000), while scene construction, autobiographical memory and future thinking are more often associated with the anterior hippocampus (Dalton & Maguire, 2017;Maguire & Mullally, 2013;Zeidman & Maguire, 2016). Understanding the specialisation of different regions of the hippocampus will also be an important topic for future work.…”

Section: Discussionmentioning

confidence: 99%

Identifying the cognitive processes underpinning hippocampal-dependent tasks

Clark

Hotchin

Monk

et al. 2018

Preprint

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Autobiographical memory, future thinking and spatial navigation are critical cognitive functions that are thought to be related, and are known to depend upon a brain structure called the hippocampus. Surprisingly, direct evidence for their interrelatedness is lacking, as is an understanding of why they might be related. There is debate about whether they are linked by an underlying memory-related process or, as has more recently been suggested, because they each require the endogenous construction of scene imagery. Here, using a large sample of participants and multiple cognitive tests with a wide spread of individual differences in performance, we found that these functions are indeed related. Mediation analyses further showed that scene construction, and not memory, mediated (explained) the relationships between the functions. These findings offer a fresh perspective on autobiographical memory, future thinking, navigation, and also on the hippocampus, where scene imagery appears to play an influential role.

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Section: Discussionmentioning

confidence: 99%

Identifying the cognitive processes underpinning hippocampal-dependent tasks

Clark

Hotchin

Monk

et al. 2018

Preprint

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“…Observed 614 coherence with the parahippocampal cortex during scene imagination is consistent with the 615 parahippocampal cortex's proposed role in processing scenes(Epstein, 2008; Mullally and Maguire, 616 2011). This connectivity profile, therefore, suggests that the anterior hippocampus may be a 617 convergence zone for appropriate object categories and their interaction within a defined space, 618 permitting the generation of scene imagery(Dalton and Maguire, 2017).619 620 In summary, our results characterise, for the first time, a core neural dynamic which underlies scene 621 construction, a process held by some to be fundamental to key cognitive functions including episodic 622 memory and future-thinking. Previous studies have demonstrated co-activation of (Hassabis et al, 623 2007b), and a dependency on (Hassabis et al, 2007a; Bertossi et al, 2016a), the hippocampus and 624 vmPFC during scene construction.…”

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confidence: 81%

The neural dynamics of novel scene imagery

Barry

Barnes

Clark

et al. 2018

Preprint

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41Retrieval of long-term episodic memories is characterised by synchronised neural activity between 42 hippocampus and ventromedial prefrontal cortex (vmPFC), with additional evidence that vmPFC 43 activity leads that of the hippocampus. It has been proposed that the mental generation of scene 44 imagery is a crucial component of episodic memory processing. If this is the case, then a comparable 45 interaction between the two brain regions should exist during the construction of novel scene 46 imagery. To address this question, we leveraged the high temporal resolution of 47 magnetoencephalography (MEG) to investigate the construction of novel mental imagery. We 48 tasked male and female humans with imagining scenes and single isolated objects in response to 49 one-word cues. We performed source level power, coherence and causality analyses to characterise 50 the underlying inter-regional interactions. Both scene and object imagination resulted in theta 51 power changes in the anterior hippocampus. However, higher theta coherence was observed 52 between the hippocampus and vmPFC in the scene compared to the object condition. This inter-53 regional theta coherence also predicted whether or not imagined scenes were subsequently 54 remembered. Dynamic causal modelling of this interaction revealed that vmPFC drove activity in 55 hippocampus during novel scene construction. Additionally, theta power changes in the vmPFC 56 preceded those observed in the hippocampus. These results constitute the first evidence in humans 57 that episodic memory retrieval and scene imagination rely on similar vmPFC-hippocampus neural 58 dynamics. Furthermore, they provide support for theories emphasising similarities between both 59 cognitive processes, and perspectives that propose the vmPFC guides the construction of context-60 relevant representations in the hippocampus. 61 62 63

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“…The subiculum plays an important role in spatial processing and navigation (Boccara et al, 2010;Dalton & Maguire, 2017;Hodgetts et al, 2017;Lever et al, 2009;Taube et al, 1990), so we expected it to be modulated by spatial attention (e.g., Aly & Turk-Browne, 2016a, 2016b.…”

Section: Introductionmentioning

confidence: 99%

Focusing on what matters: Modulation of the human hippocampus by relational attention

Córdova

Turk‐Browne

Aly³

2018

Preprint

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Hippocampal episodic memory is fundamentally relational, consisting of links between events and the spatial and temporal contexts in which they occurred. Such relations are also important over much shorter time periods, during online visual perception. For example, how do we assess the relative spatial positions of objects, their temporal order, or the relationship between their features? Here, we investigate the role of the hippocampus in such online relational processing by manipulating visual attention to different kinds of relations in a dynamic display. While undergoing high-resolution fMRI, participants viewed two images in rapid succession on each trial and performed one of three relational tasks, judging the images' relative: spatial positions, temporal onsets, or sizes. As a control, they sometimes also judged whether one image was tilted, irrespective of the other; this served as a baseline item task with no demands on relational processing. All hippocampal regions of interest (CA1, CA2/3/DG, subiculum) showed reliable deactivation when participants attended to relational vs. item information. Attention to temporal relations was associated with more robust deactivation than the other conditions. One possible interpretation of such deactivation is that it reflects hippocampal disengagement. If true, there should be reduced information content and noisier, less reliable patterns of activity in the hippocampus for the temporal vs. other tasks. Instead, analyses of multivariate activity patterns revealed more stable hippocampal representations in the temporal task. Additional analyses showed that this increased pattern similarity was not simply a reflection of the lower univariate activity. Thus, the hippocampus differentiates between relational and item processing even during online visual perception, and its representations of temporal relations in particular are robust and stable. Together, these findings suggest that the relational computations of the hippocampus, known to be important for memory, extend beyond this purpose, enabling the rapid online extraction of relational information in visual perception.

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The pre/parasubiculum: a hippocampal hub for scene-based cognition?

Cited by 78 publications

References 62 publications

Identifying the cognitive processes underpinning hippocampal-dependent tasks

Identifying the cognitive processes underpinning hippocampal-dependent tasks

The neural dynamics of novel scene imagery

Focusing on what matters: Modulation of the human hippocampus by relational attention

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