The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice

Rodríguez-Sojo, María Jesús; Ruiz-Malagón, Antonio Jesús; Hidalgo-García, Laura; Molina-Tijeras, José Alberto; Diez-Echave, Patrícia; López-Escanez, Laura; Rosati, Lucrezia; González-Lozano, Elena; Cenis-Cifuentes, Laura; García-García, Jorge; García, Féderico; Robles-Vera, Iñaki; Romero, Miguel; Duarte, Juan; Cenís, José Luis; Lozano-Pérez, Antonio Abel; Gálvez, Júlio; Rodríguez-Nogales, Alba

doi:10.3390/antiox12040978

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…On the other hand, some authors attributed metabolic deregulations and oxidative stress to changes in the intestinal microbiota composition caused by high-fat or high-fructose diets. Thus, ameliorative effects could be related to the prebiotic character of some polyphenols [ 42 , 43 , 44 ]. In fact, in a previous study, chia defatted flour showed positive effects on the intestinal microbiota using an in vitro gastrointestinal digestion model (increasing Lactobacillus and decreasing Enterobacteriaceae ) [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Chia Defatted Flour as a Nutritional Supplement in C57BL/6 Mice Fed a Low-Quality Diet

Lucini Mas,

Canalis,

Pasqualini

et al. 2024

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Today, consumption of diets rich in saturated fat and fructose, associated with a variety of metabolic deregulations, has increased. The aim of this study was to evaluate the effect of dietary supplementation with a residue of defatted chia seed on a diet with low nutritional quality. To do this, C57BL/6 male mice were fed with the Control (C), Low-Nutritional-Quality (LNQ), or supplemented-with-chia-defatted-flour (LNQ+C) diets. After 12 weeks, the glucose and lactate levels were determined in the serum, liver, and kidney, along with reactive oxygen species (ROS) levels, antioxidant enzyme activity, reduced glutathione (GSH), and protein oxidation (AOPP). The LNQ diet increased the glucose and lactate levels (+25% and +50% approx. in the liver, with respect to the control group) and generated oxidative stress by modifying the levels of ROS and the activity of antioxidant enzymes, causing oxidative damage to proteins (+12% in the liver, with respect to the control). Chia supplementation helped to restore the glucose to control levels and modulate the endogenous antioxidant system, resulting in a decrease in protein oxidation products with no differences compared to the control group. In conclusion, supplementation with chia showed beneficial effects on the general health of mice, even when fed a low-nutritional-quality diet.

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Section: Discussionmentioning

confidence: 99%

The Effects of Chia Defatted Flour as a Nutritional Supplement in C57BL/6 Mice Fed a Low-Quality Diet

Lucini Mas,

Canalis,

Pasqualini

et al. 2024

Foods

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Morus alba: natural and valuable effects in weight loss management

Ntalouka,

Tsirivakou

2024

Front. Clin. Diabetes Healthc.

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Overweight and obesity are conditions associated with serious comorbidities, such as diabetes and cardiovascular disease. Prevalence of excessive fat accumulation is increasing worldwide, and thus the need for efficient and sustainable weight loss regimes has become a major issue in clinical practice. Despite the important advances in the development of anti-obesity medications (AOM), their side effects, cost, and accessibility, are limiting factors for their routine use. Conversely, the studies of medicinal plants for weight management holds strong promise as a growing area of research. This review consolidates the representative evidence about the beneficial impacts of Morus alba on weight management and associated metabolic parameters, encompassing: inhibition of digestive enzymes, and thus contribution to the energy deficit required for weight loss, improvements in glucose and lipid metabolism, and attenuation of adiposity. Findings from in vitro, in vivo, and clinical investigations reviewed in the paper, demonstrate that white mulberry extracts have the potency to supplement efficiently and safely a healthy weight management approach.

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The Efficacy and Safety of NOVAponin (Dolichos lablab Linne Extract Powder) in Mild Functional Dyspepsia: A Single-center, Randomized, Double-Blind, Placebo-controlled Study

Choi,

Kim,

Lee

2024

J Neurogastroenterol Motil

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Background/Aims NOVAponin, a functional health food derived from Dolichos lablab Linne extract improves gastric mucosal injury and increases regeneration and proliferation. This study aims to investigate the efficacy and safety of NOVAponin in individuals with mild functional dyspepsia (FD). Methods In this single-center, double-blind, randomized clinical trial, 131 patients with FD meeting the Rome IV criteria were enrolled. Changes in the gastrointestinal symptom rating scale (GSRS), FD-related quality of life (FD-QoL), gastrointestinal symptom (GIS) scores, inflammatory and anti-inflammatory markers, and adverse effects before and after administration were compared. Results After 12 weeks of administration, GSRS upper abdominal symptom scores were significantly improved in the test group compared to the control group (–5.30 ± 0.60 vs –2.35 ± 0.56, P < 0.001). GSRS upper abdominal symptom scores (–5.13 ± 0.55 vs –1.92 ± 0.44, P < 0.001), GSRS total scores (–7.02 ± 0.91 vs –3.33 ± 0.73, P < 0.001), GIS total scores (–11.21 ± 0.53 vs –6.65 ± 0.70, P < 0.001) after 6 weeks of administration, GSRS total scores (–7.54 ± 0.94 v. –3.31 ± 0.85, P < 0.001), GIS total scores (–11.90 ± 0.52 vs –7.61 ± 0.73, P < 0.001), and FD-QoL total scores (–11.41 ± 1.75 vs –5.55 ± 1.20, P = 0.007) after 12 weeks of administration also showed significant differences between groups. The differences were slightly more pronounced in epigastric pain syndrome subtypes and in females than the others, although more females were assigned to the test group. There were no significant changes in inflammatory and anti-inflammatory markers or adverse reactions. Conclusion NOVAponin significantly improved mild FD symptoms especially in epigastric pain syndrome subtype and in females, and was found to be safe.

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The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice

Cited by 3 publications

References 61 publications

The Effects of Chia Defatted Flour as a Nutritional Supplement in C57BL/6 Mice Fed a Low-Quality Diet

The Effects of Chia Defatted Flour as a Nutritional Supplement in C57BL/6 Mice Fed a Low-Quality Diet

Morus alba: natural and valuable effects in weight loss management

The Efficacy and Safety of NOVAponin (Dolichos lablab Linne Extract Powder) in Mild Functional Dyspepsia: A Single-center, Randomized, Double-Blind, Placebo-controlled Study

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