Electrocardiograims of healthy men both native and long-term residents at 14,900 feet above sea level have been obtained and classified according to their dominant pattern. Most of the tracings showed signs of either right ventricular hypertrophy or right bundle-branch block, incomplete and complete. Some of the mechanisms responsible for these electrocardiographic changes found at high altitudes, such as pulmonary hypertension, positional changes of the heart, and chronic hypoxia, are discussed.THIE effect of chronic hypoxia due to altitude oil the right side of the heart is of particular interest. Measurements made on teleroenitgeniogramiis of the heart of normal subjects living perinianieittly-at an altitude of 14,900 feet have shown an increase in the transverse diameter of the heart and in the cardiac silhouette area, as well as a prominent )ullIlOlary-coitus. 1 Complementary fluoroscopic studies have demonstrated that an increase inl the volume of the right cavities rather than a total involvement is responsible for heart enlargememmt.4More recently, by means of cardiac catheterization, a moderate but significant increase of the pulmonary artery pressure and of total pulmonary resistance has been found in men at high altitudes.6 Finally, a variable grade of right ventricular hypertrophy has been found in a small nurnber of postmortem observations on subjects at high altitudes dying from work accidents.7TIme preceding, information, as well as preliiminary eleetrocardiographie observations carried out at this same altitude,4 at lower altitudes,5 and on1 miners without pulmonary silicosis from various altitudes and studied at sea level after several days of residence9 suggests that normal miie living at high altitudes must show some electrocardiographie signs of right ventricular hypertrophy. The work reported here was designed to shed some light on this problem. Accordingly, electrocardiograms of a group of normal subjects residing at higlh altitudes were taken and compared with normal staiidards at sea level. Electrocardiog ramiis were taken during rest in the supine position, with Sanborn Viso-Cardiette and Cambridge Simple-Trol electrocardiographs.The standard leads, 3 augmented unipolar limb leads, and 7 unipolar precordial leads from RV3 to V6 were recorded. In 18 instances RV3 was not registered; in 5 cases, the VE lead was recorded instead of RVY, and in 6 additional cases leads from right precoidiumai (RV4, RV5, and RV6) were taken. In all tracings height and duration of the P, R, S, and T waves in standard and precordial leads were tmeasured. The ventricular activation time (tinte of onset of the intrinsic deflection), from the beginning of QRS complex to the peak of R wave, was measured in V1, V5, and V6. The mean electric axis of QRS and the R/S ratio in V1, V,, and V6 were determined.