“…The precordially recorded isotope dilution curve has in recent years gained use in the study of hemodynamics in heart disease (8,10,11,12,13,14), as it gives more direct evidence of circulation in the heart and lungs. Precordial isotope dilution determinations have been performed on patients with mitral valvular disease (10, 1 1) and some observations have been published on the use of the method in aortic valvular disease (11,14).…”