The predicted lifetime costs and health consequences of calcium and vitamin D supplementation for fracture prevention—the impact of cardiovascular effects

Hagen, Gunhild; Wisløff, Torbjørn; Kristiansen, Ivar Sønbø

doi:10.1007/s00198-016-3495-9

Cited by 3 publications

(9 citation statements)

References 41 publications

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“…Furthermore, vitamin D deficiency has been identified as a risk factor for myocardial infarction, heart failure, and inflammatory cardiovascular disease [12-14]. Clinical reports have confirmed that vitamin D could regulate blood pressure in healthy individuals [15] and decrease high blood pressure in patients [15, 16].…”

Section: Introductionmentioning

confidence: 96%

Vitamin D Ameliorates Angiotensin II-Induced Human Endothelial Progenitor Cell Injury via the PPAR-γ/HO-1 Pathway

et al. 2019

J Vasc Res

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Vitamin D has an important protective effect on chronic inflammatory disease. Angiotensin II (AngII) triggers vascular damage and plays a key role in vascular diseases via several mechanisms, including inflammation. Conversely, vitamin D has been shown to have an important protective effect on chronic inflammation. There is evidence showing that vitamin D can reverse the effects of AngII, but the molecular mechanisms by which this occurs are not known. Our results demonstrate that vitamin D improved the viability, migration ability, and tube formation of AngII-pretreated endothelial progenitor cells (EPCs) and inhibited the apoptosis of EPCs induced by AngII. Vitamin D also reversed reactive oxygen species production, vascular inflammatory cytokine generation, and nuclear factor kappa-B activation in EPCs induced by AngII. Furthermore, EPC pretreatment with GW9662 (the antagonist for PPAR-γ) or siHO-1 decreased the protective effect of vitamin D on AngII-induced EPC injury. Overall, our data indicate that vitamin D ameliorated AngII-induced abnormal EPC injury by decreasing oxidative stress and inflammatory cytokine levels. These findings also suggest that vitamin D protected EPCs from AngII-induced vascular injury via the activation of the PPAR-γ/HO-1 signaling pathway.

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Section: Introductionmentioning

confidence: 96%

Vitamin D Ameliorates Angiotensin II-Induced Human Endothelial Progenitor Cell Injury via the PPAR-γ/HO-1 Pathway

et al. 2019

J Vasc Res

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“…Five of these studies (17, 18, 21–23) assessed the public health and/economic impact of dairy products (also called vitamin D-fortified dairy products, vitamin D and calcium food fortification, vitamin D-rich dairy products) while two studies (19, 20) assessed the impact of calcium and vitamin D supplementation without mentioning the specific use of dairy products. Four studies assessed the public health impact of dairy products in terms of costs, number of fractures prevented, life years gained, DALY gained or QALY gained (17, 21–23) and all studies except the study of Lotters assessed the cost-effectiveness of dairy products (or calcium and vitamin D supplementation).…”

Section: Resultsmentioning

confidence: 99%

“…Four studies assessed the public health impact of dairy products in terms of costs, number of fractures prevented, life years gained, DALY gained or QALY gained (17, 21–23) and all studies except the study of Lotters assessed the cost-effectiveness of dairy products (or calcium and vitamin D supplementation). Four studies estimated the cost per QALY gained of dairy products (17, 19–21), one assessed the cost per fracture prevented and cost per life year gained (17), and one study used a benefit-cost ratio comparing costs and fractures prevented (23). …”

Section: Resultsmentioning

confidence: 99%

“…Three studies were conducted in Belgium (17, 18, 20), one in France (21), one in Germany (23), one in Norway (19) and one study included three countries (i.e. Sweden, the Netherlands and France) (22).…”

Section: Resultsmentioning

confidence: 99%

“…Lotters et al (22) assessed the potential impact of increasing dairy foods consumption in people with an inadequate calcium intake. Hagen et al (19) assessed the impact of cardiovascular effects on the cost-effectiveness of calcium and vitamin D supplementation.…”

Section: Resultsmentioning

confidence: 99%

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A scoping review of the public health impact of vitamin D-fortified dairy products for fracture prevention

et al. 2017

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PurposeDairy products are rich in nutrients that positively influence bone health and hence fracture risk, and have therefore been recommended and used for fracture prevention. To help decision makers to efficiently allocate scare resources, it is further important to assess the public health and economic impact of any health intervention. In recent years, several studies have been conducted to estimate the public health and/or economic impact of dairy products but no overview is currently available. This article aims therefore to summarize evidence and review articles that estimated the public health and/or economic impact of vitamin D-fortified dairy products for fracture prevention.MethodsA literature review was conducted using PubMed to identify original studies that assessed the public health and/or economic impact of dairy products (or of calcium/vitamin D supplementation) for fracture prevention up to January 15, 2017.ResultsSeven articles were identified. Different strategies were used by the authors to model the economic/public health impact of dairy products. The four studies assessing the public health impact of dairy products revealed a substantial benefit in terms of fracture prevented, life years, disability-adjusted life years and/or quality-adjusted life years gained. Studies assessing the cost-effectiveness revealed that the use of dairy products is generally cost-effective in the general population aged above 70 years, and from the age of 60 years in populations at high risk of fractures.ConclusionThis systematic review suggests that the use of dairy products could substantially reduce the burden of osteoporotic fractures and seem to be an economically beneficial strategy.

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Calcium and Vitamin D Supplementation. Myths and Realities with Regard to Cardiovascular Risk

Muscogiuri

Barrea

Altieri

et al. 2019

CVP

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Vitamin D and calcium are considered crucial for the treatment of bone diseases. Both vitamin D and calcium contribute to bone homeostasis but also preserve muscle health by reducing the risk of falls and fractures. Low vitamin D concentrations result in secondary hyperparathyroidism and contribute to bone loss, although the development of secondary hyperparathyroidism varies, even in patients with severe vitamin D deficiency. Findings from observational studies have shown controversial results regarding the association between bone mineral density and vitamin D/calcium status, thus sparking a debate regarding optimum concentrations of 25-hydroxyvitamin D and calcium for the best possible skeletal health. Although most of the intervention studies reported a positive effect of supplementation with calcium and vitamin D on bone in patients with osteoporosis, this therapeutic approach has been a matter of debate regarding potential side effects on the cardiovascular (CV) system. Thus, the aim of this review is to consider the current evidence on the physiological role of vitamin D and calcium on bone and muscle health. Moreover, we provide an overview on observational and interventional studies that investigate the effect of vitamin D and calcium supplementation on bone health, also taking into account the possible CV side-effects. We also provide molecular insights on the effect of calcium plus vitamin D on the CV system.

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The predicted lifetime costs and health consequences of calcium and vitamin D supplementation for fracture prevention—the impact of cardiovascular effects

Abstract: We conclude that the magnitude of potential cardiovascular side effects is crucial for the effectiveness and cost-effectiveness of CaD supplementation in elderly women.

Cited by 3 publications

References 41 publications

Vitamin D Ameliorates Angiotensin II-Induced Human Endothelial Progenitor Cell Injury via the PPAR-γ/HO-1 Pathway

Vitamin D Ameliorates Angiotensin II-Induced Human Endothelial Progenitor Cell Injury via the PPAR-γ/HO-1 Pathway

A scoping review of the public health impact of vitamin D-fortified dairy products for fracture prevention

Calcium and Vitamin D Supplementation. Myths and Realities with Regard to Cardiovascular Risk

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