The prediction of Metabolic Syndrome alterations is improved by combining waist circumference and handgrip strength measurements compared to either alone

López‐López, José; Cohen, Daniel D.; Ney-Salazar, Daniela; Martinez, Daniel; Otero, Johanna; Gómez-Arbeláez, Diego; Camacho, Paul Anthony; Valle, Adriana Polachini do; Arcos, Édgar; Narváez, Claudia; García, Henry; Pérez, Maritza; Molina, Dora I.; Cure, Carlos; Sotomayor, A; Rico, A.; Hernandez-Triana, Eric; Duran, Myriam; Cotes, Fresia; Leong, Darryl P.; Rangarajan, Sumathy; Yusuf, Salim; López‐Jaramillo, Patricio

doi:10.1186/s12933-021-01256-z

Cited by 32 publications

(20 citation statements)

References 45 publications

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“…In women, all results showed no association results [17,18]. Some of the results showed significant results in men [24]. Weight- [16,20,21,23] and BMIrelative [4,[17][18][19] HGS were consistently associated with MetS both men and women.…”

Section: Discussionmentioning

confidence: 80%

“…The average muscle strength was used for this study. Body mass index (BMI), body weight, and WC are well-known factors used for relative muscle strength [4,[14][15][16][17][18][19][20][21][22][23][24][25]. Relative muscle strength was calculated as the muscle strength divided by BMI, body weight, and WC for analysis independent of body composition.…”

Section: Muscle Strengthmentioning

confidence: 99%

“…Until recently, most studies of HGS, relative HGS, and MetS have reported crosssectional findings [4,[16][17][18][19][20][21][22][23][24][25], with one follow-up investigation reported [26]. Moreover, adolescent studies have shown that weight relative HGS is associated with MetS [22].…”

Section: Introductionmentioning

confidence: 99%

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Relative Hand Grip and Back Muscle Strength, but Not Mean Muscle Strength, as Risk Factors for Incident Metabolic Syndrome and Its Metabolic Components: 16 Years of Follow-Up in a Population-Based Cohort Study

Jeon

Lee²,

Shin³

2021

Applied Sciences

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Muscle strength is associated with health outcomes and can be considered an important disease predictor. There are several studies examining the relationship between hand grip strength (HGS) and metabolic syndrome (MetS). However, no results have been reported for long term longitudinal studies. In this study, we investigated the relationship between mean HGS, back muscle strength (BMS), relative HGS and BMS, and MetS. A total of 2538 non-MetS subjects aged 40–69 years (1215 women and 1323 men) in the Korean Genome and Epidemiology Study (KoGES) Ansan cohort were followed for 16 years. The relationships between incident MetS (iMetS) and muscle strength were estimated using Cox proportional hazard regression models after adjusting for the confounding factors. Increases in standard deviation (SD) and the lower quartile groups for relative HGS and BMS were significantly associated with iMetS in men and women. Moreover, increases in SD and high quintile groups (decreased HGS group) for the delta change in the mean and relative HGS were significantly associated with iMetS in men only. In addition, SD increases for the relative HGS and BMS were significantly associated with iMetS components in men and women. The present study suggests that lower relative HGS and BMS are associated with high risk for the future development of MetS.

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Section: Discussionmentioning

confidence: 80%

Section: Muscle Strengthmentioning

confidence: 99%

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Relative Hand Grip and Back Muscle Strength, but Not Mean Muscle Strength, as Risk Factors for Incident Metabolic Syndrome and Its Metabolic Components: 16 Years of Follow-Up in a Population-Based Cohort Study

Jeon

Lee²,

Shin³

2021

Applied Sciences

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“…In contrast, bioelectrical impedance analysis (BIA) developed as a highly accurate method that is suitable for evaluating the body composition. Third, low muscle strength has also been identified as a risk factor for MS in recent studies [ 34 , 35 ]. However, we did not measure muscle function or strength in this study; therefore, the role of muscle strength in metabolic disorders is perhaps neglected.…”

Section: Discussionmentioning

confidence: 99%

The association between fat-to-muscle ratio and metabolic disorders in type 2 diabetes

Liu

Zhong

Ruan

et al. 2021

Diabetol Metab Syndr

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Background Altered body composition is known to be related to abnormal metabolism. The aim of this study was to determine the association between the fat-to-muscle ratio (FMR) and metabolic disorders in type 2 diabetes (T2DM) population. Method In total, 361 T2DM participants aged ≥ 18 years were included in our research. A bioelectrical impedance analyzer was applied to measure fat mass and muscle mass. FMR was calculated as body fat mass (kg) divided by muscle mass (kg). The performance of FMR to assess metabolic disorders in T2DM was conducted using ROC curves. The independent association between FMR and metabolic syndrome (MS) was tested by logistic regression analysis. Results The FMR was significantly higher in patients with MS than in those without MS (p < 0.001). The optimal FMR cutoff point for identifying MS was higher in females than in males (0.465 vs. 0.296, respectively). In addition, the areas under the ROC curve (AUCs) for the evaluation of MS by FMR, fat mass, muscle mass, BMI and waist circumference were further compared, indicating that the AUC of FMR (0.843) was the largest among the five variables in females, but the AUC of waist circumference (0.837) was still the largest among other variables in males. Based on the derived FMR cutoff point, patients with a high FMR exhibited more cardiometabolic risk indicators (all p < 0.05). Using a low FMR as a reference, the relative risk of a high FMR for MS was 2.861 (95% CI 1.111–7.368, p = 0.029) in males and 9.518 (95% CI 2.615–34.638, p = 0.001) in females following adjustment for confounding factors. Conclusions The fat-to-muscle ratio is independently and positively associated with metabolic disorders in T2DM. FMR may serve as an optimal method for screening T2DM patients coupled with a high risk of abnormal metabolism, especially in females, providing a new perspective for the prevention and treatment of cardiovascular complications in Chinese type 2 diabetes.

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“…Recently, adolescent hypertension has been shown to promote early onset type 2 diabetes [ 5 ] which has even more deleterious cardiovascular sequela compared to later onset diabetes [ 44 ]. Moreover, elevated blood pressure is a central factor of the metabolic syndrome [ 45 ] representing insulin resistance which is induced by obesity [ 46 ]. Nevertheless, we observed opposite trends of the BMI and the BP among adolescents throughout the study period, while other traditional environmental and behavioral risk factors are considered to remain stable throughout the years.…”

Section: Discussionmentioning

confidence: 99%

The opposing trends of body mass index and blood pressure during 1977–2020; nationwide registry of 2.8 million male and female adolescents

Fishman

Zloof

Orr

et al. 2021

Cardiovasc Diabetol

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Background Elevated blood pressure among adolescents has been shown to be associated with future adverse cardiovascular outcomes and early onset diabetes. Most data regarding systolic and diastolic blood pressure trends are based on surveys of selected populations within 10–20-year periods. The goal of this study was to characterize the secular trend of blood pressure given the rising prevalence of adolescent obesity. Methods This nationwide population-based study included 2,785,515 Israeli adolescents (41.6% females, mean age 17.4 years) who were medically evaluated and whose weight, height and blood pressure were measured, prior to mandatory military service between 1977 and 2020. The study period was divided into 5-year intervals. Linear regression models were used to describe the P for trend along the time intervals. Analysis of covariance was used to calculate means of blood pressure adjusted for body mass index. Results During the study period, the mean body mass index increased by 2.1 and 1.6 kg/m2 in males and females, respectively (P for trend < 0.001 in both sexes). The mean diastolic blood pressure decreased by 3.6 mmHg in males and by 2.9 mmHg in females (P < 0.001 in both sexes). The mean systolic blood pressure increased by 1.6 mmHg in males and decreased by 1.9 mmHg in females. These trends were also consistent when blood pressure values were adjusted to body mass index. Conclusion Despite the increase in body mass index over the last four decades, diastolic blood pressure decreased in both sexes while systolic blood pressure increased slightly in males and decreased in females.

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The prediction of Metabolic Syndrome alterations is improved by combining waist circumference and handgrip strength measurements compared to either alone

Cited by 32 publications

References 45 publications

Relative Hand Grip and Back Muscle Strength, but Not Mean Muscle Strength, as Risk Factors for Incident Metabolic Syndrome and Its Metabolic Components: 16 Years of Follow-Up in a Population-Based Cohort Study

Relative Hand Grip and Back Muscle Strength, but Not Mean Muscle Strength, as Risk Factors for Incident Metabolic Syndrome and Its Metabolic Components: 16 Years of Follow-Up in a Population-Based Cohort Study

The association between fat-to-muscle ratio and metabolic disorders in type 2 diabetes

The opposing trends of body mass index and blood pressure during 1977–2020; nationwide registry of 2.8 million male and female adolescents

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