The prediction of preterm delivery: What is new?

Suff, Natalie; Story, Lisa; Shennan, Andrew

doi:10.1016/j.siny.2018.09.006

Cited by 93 publications

(89 citation statements)

References 71 publications

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“…Comparing to be a regulator, circRNA may have the unique advantage to be a biomarker. At present, two of the most commonly used biomarkers for PTB prediction were fFN and placental alpha-macroglobulin-1 (PAMG-1; Suff et al, 2019). These two tests were usually performed in the third trimester of gestation (25-34 weeks gestation) and had notable high NPV (97.9%, 98.3%) but low PPV (7.9%, 35.3%) for the prediction of PTB within 7 days (Wing et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Even the most widely used clinical test, fetal fibronectin (fFN), can only roughly assess the risk of PTB, but cannot suggest potential pathological changes before the occurrence of PTB (Berghella and Saccone, 2019). It would facilitate treatment and significantly improve the outcome of premature babies if PTB can be predicted earlier (Suff et al, 2019). However, there are still numerous challenges today (Glover and Manuck, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth

Ran

Yin

Huang

et al. 2020

Front. Bioeng. Biotechnol.

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Preterm birth (PTB), as the leading cause of neonatal death, is a severe threat to maternal–fetal health. The diagnosis and treatment of PTB are difficult as its underlying mechanism still unknown. Circular RNA (circRNA) is an emerging molecule that plays an essential role in the pathological processes of various diseases. However, it is still unclear whether circRNAs are abnormal or involves in the PTB pathology. In this study, we analyzed RNA-seq data of peripheral blood from preterm and term pregnant women and verified with microarray data. There were 211 circRNA expression disorders in PTB, of which 68 increased and 143 decreased. Bioinformatics analysis revealed that the top 20 circRNAs competitively bind 68 miRNAs, thereby regulating 622 mRNAs mainly related to immunity, inflammation, and nerve activity, which may ultimately contribute to the occurrence of PTB. Moreover, 6 regulatory pairs, including hsa-MORC3_0001–hsa-miR-1248–CHRM2 were the core parts of this mechanism network, which might be therapeutic targets for PTB. Besides, ROC analysis indicated that hsa-ANKFY1_0025, hsa-FAM13B_0019, and hsa-NUSAP1_0010 (AUC = 0.7138, 0.9589, 1.000) have an excellent discrimination ability for PTB. Taken together, we explored for the first time the circRNA expression profile of PTB, and preliminarily analyzed its regulatory mechanism and predictive value for PTB, thus bringing new light to the diagnosis and treatment of PTB.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth

Ran

Yin

Huang

et al. 2020

Front. Bioeng. Biotechnol.

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show abstract

“…Prediction of PTB allows for targeted intervention for high risk women, such as cervical cerclage, antenatal corticosteroids, magnesium sulphate and tocolyis, that may prevent or optimise preterm delivery [13]. In addition, low predictive scores may provide reassurance for women and reduce maternal anxiety about the risk of recurrent PTB in subsequent pregnancies [13].…”

Section: Introductionmentioning

confidence: 99%

Prediction of recurrent preterm delivery in asymptomatic women- an anxiety reducing measure?

Petch

DeMaio

Daly

2019

European Journal of Obstetrics & Gynecology and Reproductiv

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ObjectivesThe QUiPP application is used to predict the risk of recurrent preterm birth (PTB) in asymptomatic high risk women with a previous PTB. Our study aims to evaluate the impact of the use of the QUiPP app on maternal anxiety levels.Study designA retrospective cohort study on asymptomatic pregnant women attending the Prevention of Preterm Birth Clinic in a busy tertiary unit. Women included in the study had a history of previous PTB. The study assessment occurred at approximately 4 weeks prior to the gestation of the earliest previous PTB and included measurement of cervical length and vaginal fetal fibronectin. Data was inputted into the QUiPP application, which in turn estimated risk of preterm delivery at specific intervals. Measured outcomes were gestation at delivery, time from risk assessment to delivery, infant birth weight, NICU admission and length of stay. In addition, maternal anxiety levels were retrospectively assessed using a questionnaire with a Likert scale.ResultsSeventy six women were included in the study. All women were asymptomatic for preterm labour at assessment. The mean gestation at the time of risk assessment was 27 weeks, the mean time from risk assessment to delivery was 72 days. Average gestation at time of delivery was 37 weeks (range 22–42 weeks). The preterm birth rate was 29% (n = 22).Seventy seven percent of women who delivered <37 weeks, and 80% who delivered <34 weeks were given QUiPP scores predicting a ≥5% chance of PTB within four weeks of their actual delivery date. Sixteen percent of infants were admitted to NICU (n = 12) with a mean length of stay of 21 days. All infants went home well with their parents.Eighty four percent of respondents to our questionnaire reported feeling anxious about their pregnancy prior to attending the clinic. After receiving a QUIPP score 90% said they felt reassured and 79% reported that the felt less anxious.ConclusionIn asymptomatic women, the use of the QUiPP app helps to predict, prevent, and optimise PTB. This surveillance has a beneficial role for maternal mental well-being in that it reduces anxiety at a key time during a pregnancy.

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“…Worldwide, the preterm birth rate is of 11.1%, meaning that 15 million babies are born before 37 weeks of gestation every year, the leading cause of mortality in children aged <5 years, and of severe, life-long neurological sequelae [ 44 ].…”

Section: Also In This Issuementioning

confidence: 99%

Protecting the blossoming brain – Neurocritical care in children

Häfner

2020

Biomedical Journal

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This special issue of the Biomedical Journal is entirely dedicated to the latest updates regarding the medical efforts to preserve the fragile young brain after injury. Thereby, we learn about symptoms and diseases such as different forms of epilepsy, acute encephalopathy, increased intracranial pressure, and posthaemorrhagic hydrocephalus, as well as about their origins, such as infection, autoimmune diseases, preterm birth, or abusive head trauma. Moreover, diagnosis and surveillance techniques are discussed, including ultrasound of the optic nerve sheath diameter and multimodal monitoring. Finally, we discover various established and emerging therapeutic approaches, comprising target temperature management, ketogenic diet, and immunomodulation.

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The prediction of preterm delivery: What is new?

Cited by 93 publications

References 71 publications

Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth

Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth

Prediction of recurrent preterm delivery in asymptomatic women- an anxiety reducing measure?

Protecting the blossoming brain – Neurocritical care in children

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