The prediction of recurrence in meningiomas.

Crompton, M. R.; Gautier-Smith, P. C.

doi:10.1136/jnnp.33.1.80

Cited by 115 publications

(25 citation statements)

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“…3) MIB-1 SI and recurrence or regrowth of meningiomas in relation to the extent of tumor removal Some reports have shown that the degree of surgical removal, namely, Simpson's grading, is closely related to future recurrence [3,8,11,27,29]. Then, in order to predict the future recurrence of meningioma on the basis of MIB-1 SI of meningiomas more precisely, the tumors should be assigned to each group of Simpson's grade and the relationship between MIB-1 SI and recurrence should be analyzed individually.…”

Section: ) Mib-1 Si and Histopathological Subtypes Of Meningiomasmentioning

confidence: 99%

“…They comprise a heterogeneous group of tumors that is categorized into 15 subtypes [27]. Several investigators have studied the clinical and biological features of recurrent and nonrecurrent meningiomas [3,8,10,11,14,20,21,31,35,36,52]. In recent years, meningiomas have been analyzed by histopathological examination focused on their proliferative potentials.…”

Section: Introductionmentioning

confidence: 99%

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Histopathological Analyses of Proliferative Potentials of Intracranial Meningiomas Using Bromodeoxyuridine and MIB-1 Immunohistochemistry

Matsuno

Nakaguchi

Nagashima

et al. 2005

Acta Histochem. Cytochem

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The proliferative potentials of intracranial meningiomas, as represented by bromodeoxyuridine (BrdU) labeling index (LI) and MIB-1 staining index (SI), were examined, and their correlation with recurrence and regrowth of meningiomas was reviewed. The mean BrdU LI of recurrent meningiomas was reported to be significantly higher than that of nonrecurrent meningiomas. BrdU LI can predict the time to re-operation. Many studies have been conducted to examine the relationship between MIB-1 SI and clinical outcome of meningiomas, and most of them showed a significant relationship. Time interval to next recurrence in recurrent meningiomas is associated with MIB-1 SI, and several investigators have shown a cut-off point for MIB-1 SI that can predict future recurrence. BrdU LI, MIB-1 SI, and tumor doubling time of intracranial meningiomas have a mutual relationship. While many other biological or genetic variables can affect the proliferation of tumors, nevertheless BrdU LI and MIB-1 SI are closely correlated with clinical recurrence or regrowth of meningiomas.

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Section: ) Mib-1 Si and Histopathological Subtypes Of Meningiomasmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histopathological Analyses of Proliferative Potentials of Intracranial Meningiomas Using Bromodeoxyuridine and MIB-1 Immunohistochemistry

Matsuno

Nakaguchi

Nagashima

et al. 2005

Acta Histochem. Cytochem

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“…2,3) The most common mechanism of central necrosis in meningioma is suggested to be ischemia caused by sudden occlusion of tumor feeding arteries. 11) However, present histological specimens show no obstructive vessel in the viable tumor.…”

Section: Discussionmentioning

confidence: 99%

“…4) However, approximately 10-15% of benign meningiomas have atypical neuroradiological patterns such as rim-like enhancement or cyst formation, which may indicate central necrosis. 1,2,17) The mechanism of central necrosis has not been clarified in detail, and only a few reports have documented progressive central necrosis with serial neuroradiological images. 18) Here we describe a case of meningioma with acute deterioration due to central necrosis triggered by acute anemia, with serial neuroradiological images.…”

Section: Introductionmentioning

confidence: 99%

Central Tumor Necrosis of a Large Meningioma Following Acute Anemia Caused by Hysterectomy -Case Report-

Kano

Kobayashi

Yoshida

et al. 2009

Neurol. Med. Chir.(Tokyo)

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A 55-year-old woman, with a one-year history of headache, gait disturbance, and slight aphasia, was transferred to our hospital after head injury. Magnetic resonance (MR) imaging and computed tomography revealed a large meningioma with peripheral edema. However, priority was given to previously planned gynecological surgery for uterine cancer. She developed severe anemia after the surgery, followed by consciousness disturbance. MR imaging revealed spontaneous tumor necrosis. The meningioma was totally removed. Her consciousness improved, and she was discharged with no neurological deficit. Patients with large meningioma may suffer deterioration of symptoms due to central tumor necrosis triggered by acute anemia.

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“…It has been suggested that the tumor proliferative potential can be used to describe the clinical course of meningiomas, together with other parameters [1,2,5,9,12,13,17,18,21,[23][24][25]. The Ki-67 antigen has been shown in several studies to be a reliable indicator of biological activity of the tumor as its expression represents proliferating cells only.…”

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confidence: 99%