The Predictive Levels of Serum Anti-Müllerian Hormone and the Combined Index of the Number of Retrieved Oocytes and Good-Quality Embryos in Advanced-Age Infertile Women

Sun, Tie-Cheng; Chen, Xi; Shi, Cheng; Tian, Li; Zhou, Shan-Jie

doi:10.1155/2022/4224417

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…This study’s greatest strength is its large sample size. With 10,778 included cycles, the sample size of this study is 1–2 orders of magnitude greater than other recent studies investigating the relationship between diminished ovarian reserve and oocyte quality including embryo aneuploidy [ 22 – 27 , 31 , 32 ]. Several limitations are acknowledged.…”

Section: Discussionmentioning

confidence: 99%

“…A 2022 study of 231 patients found only an association between AMH and Day 5 embryo quality, but not between AMH and Day 3 embryo quality or clinical pregnancy rate [ 26 ]. Another study found that, among 521 patients, AMH was predictive of oocytes retrieved, but not predictive of obtaining “good quality” embryos [ 27 ]. In an analysis of 492 IVF/ICSI cycles, patients with low AMH (< 1.1 ng/ml) had greater rates of cycle cancelation, fewer oocytes, and slightly lower rates of Grade I-II embryo formation, but no differences in fertilization, blastocyst formation, implantation rates, as well rates of miscarriage and livebirth.…”

Section: Introductionmentioning

confidence: 99%

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AMH independently predicts aneuploidy but not live birth per transfer in IVF PGT-A cycles

Seifer

Tal

2023

Reprod Biol Endocrinol

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Background While anti-Müllerian hormone (AMH) predicts quantitative IVF outcomes such as oocyte yield, it is not certain whether AMH predicts markers of oocyte quality such as aneuploidy. Methods Retrospective case–control analysis of the SART-CORS database, 2014–2016, to determine whether anti-Müllerian hormone (AMH) predicts aneuploidy and live birth in IVF cycles utilizing preimplantation genetic testing for aneuploidy (PGT-A). Results Of 51,273 cycles utilizing PGT-A for all embryos, 10,878 cycles were included in the final analysis; of these, 2,100 cycles resulted in canceled transfer due to lack of normal embryos and 8,778 cycles resulted in primary FET. AMH levels of cycles with ≥ 1 euploid embryo were greater than those of cycles with no normal embryos, stratifying by number of embryos biopsied (1–2, 3–4, 5–6, and ≥ 7), P < 0.017 for each stratum. Adjusting for age and number of embryos biopsied, AMH was a significant independent predictor of ≥ 1 euploid embryo for all age groups: < 35 yrs (aOR 1.074; 95%CI 1.005–1.163), 35–37 years (aOR 1.085; 95%CI 1.018–1.165) and ≥ 38 years (aOR 1.055; 95%CI 1.020–1.093). In comparative model analysis, AMH was superior to age as a predictor of ≥ 1 euploid embryo for age groups < 35 years and 35–37 years, but not ≥ 38 years. Across all cycles, age (aOR 0.945, 95% CI 0.935–0.956) and number of embryos (aOR 1.144, 95%CI 1.127–1.162) were associated with live birth per transfer, but AMH was not (aOR 0.995, 95%CI 0.983–1.008). In the subset of cycles resulting in ≥ 1 euploid embryo for transfer, neither age nor AMH were associated with live birth. Conclusions Adjusting for age and number of embryos biopsied, AMH independently predicted likelihood of obtaining ≥ 1 euploid embryo for transfer in IVF PGT-A cycles. However, neither age nor AMH were predictive of live birth once a euploid embryo was identified by PGT-A for transfer. This analysis suggests a predictive role of AMH for oocyte quality (aneuploidy risk), but not live birth per transfer once a euploid embryo is identified following PGT-A.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

AMH independently predicts aneuploidy but not live birth per transfer in IVF PGT-A cycles

Seifer

Tal

2023

Reprod Biol Endocrinol

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“…AMH, AFC, and bFSH are now acknowledged as reliable serum markers of ovarian reserve [24]. Nevertheless, AMH and AFC are predominantly utilized for predicting the number of oocytes and are not indicative of embryo quality; their predictive e cacy is too restricted for clinical signi cance [25]. Elevated bFSH levels re ect a quantitative rather than qual-itative decline in ovarian reserve [26].…”

Section: Discussionmentioning

confidence: 99%

Melatonin Levels and Embryo Quality in IVF Patients with Diminished Ovarian Reserve: A Comparative Study

Wang,

Liu,

Gan

et al. 2024

Preprint

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Background Melatonin, a hormone found in various bodily fluids and cells, is known for its potent antioxidative, anti-apoptotic, and endocrine regulatory properties. This study aimed to analyze melatonin levels in patients with diminished ovarian reserve (DOR) and its impact on embryo quality. Methods we enrolled 85 women who were undergoing in vitro fertilization or intracytoplasmic sperm injection procedures, including normal ovarian reserve (NOR, n = 27), pathological DOR (DOR-Path, n = 25), and physiological DOR (DOR-Phy, n = 33). Melatonin levels in patient serum and follicular fluid were assessed using ELISA, and correlations between melatonin levels and indicators of embryo quality were examined. Results Our findings indicate that melatonin levels in the follicular fluid and basal serum of the DOR-Path and DOR-Phy groups were lower compared to the NOR group (P < 0.05). However, no significant differences in melatonin levels were found between the DOR-Path and DOR-Phy groups (P > 0.05). Additionally, the concentration of melatonin in the follicular fluid of the NOR group was significantly higher than in their serum (P < 0.001). Lastly, a significant correlation was discovered between melatonin levels in serum and follicular fluid and parameters of ovarian reserve and embryonic development (P < 0.05). Conclusions Melatonin levels in DOR patients may impact embryo quality, offering insights into potential DOR pathogenesis and opportunities to enhance treatment outcomes in these patients.

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Effects of ovarian response prediction index and follicle-oocyte index on pregnancy outcomes: a retrospective cohort study of 12,218 fresh transfer cycles

Wang,

Tan,

Ding

et al. 2024

Reproductive and Developmental Medicine

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Objective: To investigate the potential relationships among the ovarian response prediction index (ORPI), follicle-oocyte index (FOI), and clinical pregnancy rate (CPR) in women undergoing their first in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) fresh cycle transfer. Methods: In this retrospective cohort study, we included 12,218 women who underwent their first IVF/ICSI-ET cycle between December 2014 and January 2021. The primary and secondary outcomes of our study were CPR and cumulative live birth rate (CLBR), respectively. The data were divided into three groups according to the ORPI and FOI tertiles. Multivariate logistic regression analyses, stratification analyses, interaction, restricted cubic splines, and receiver operating characteristic (ROC) curves were constructed to identify the relationships among ORPI, FOI, and CPR. Results: A statistically significant increase in CPR was detected from the lowest to the highest tertile group (ORPI: 48.12%, 54.07%, and 53.47%, P <0.001; FOI:49.99%, 52.95%, and 52.71%, P=0.012). A higher CLBR was observed in the high group (ORPI: 38.63%, 44.62%, and 44.19%, P <0.001; FOI: 41.02%, 43.78%, and 42.59%, P=0.039). Multivariate logistic regression analysis revealed no statistically significant differences between ORPI, FOI, and neither CPR [odds ratio (OR) (95% confidence interval (CI), 0.99 (0.97-1.00) vs. (1.02 (0.84-1.24)] nor CLBR [OR (95% CI), 0.99 (0.97-1.01) vs. 0.99 (0.81-1.20)]. No significant association was found among FOI, ORPI, and CPR, even in the subgroups. Restricted cubic spline analyses indicated the existence of a nonlinear relationship across the entire range of FOI and ORPI. The ORPI and FOI variables had poor predictive ability (AUC< 0.60) for CPR. Conclusions: Both ORPI and FOI are not reliable predictors of clinical pregnancy or live birth outcomes in fresh embryo transfers. Clinicians and researchers should avoid using FOI and ORPI to assess pregnancy outcomes after fresh embryo transfer because of their limited relevance and predictive value.

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The Predictive Levels of Serum Anti-Müllerian Hormone and the Combined Index of the Number of Retrieved Oocytes and Good-Quality Embryos in Advanced-Age Infertile Women

Cited by 4 publications

References 36 publications

AMH independently predicts aneuploidy but not live birth per transfer in IVF PGT-A cycles

AMH independently predicts aneuploidy but not live birth per transfer in IVF PGT-A cycles

Melatonin Levels and Embryo Quality in IVF Patients with Diminished Ovarian Reserve: A Comparative Study

Effects of ovarian response prediction index and follicle-oocyte index on pregnancy outcomes: a retrospective cohort study of 12,218 fresh transfer cycles

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