Aging is described as progressive change in psychological, biological and social structure of persons. The advanced age contributed negatively to self-care. The relocation to care homes considered as stressful event for the elderly people. The purpose of this study to find the relationship between psychological well-being and self-care among the elderly residents at nursing homes in middle Euphrates in Iraq. A descriptivecorrelational design was used to gather the information from the sample of 60 participants in nursing homes.The study has been carried out from November, 1st, 2019 to August, 2020. Purposive sample used to collect the data according to some criteria. The data collected by means of Ryff scales of psychological well-being (shorten version) and self-care questionnaire as well as the socio-demographical of study sample. The data collected by using structured interview technique with the elderly residents in nursing homes. The data collected by means of Ryff scales of psychological well-being (shorten version) and self-care questionnaire as well as the socio-demographical of study sample. The data collected by using structured interview technique with the elderly residents in nursing homes. The results of study indicate that a relationship exists between psychological well-being and self-care among the elderly residents in nursing homes. As the relationship between the two variables is a high significant positive relationship (r = 0.721). The recommendations focus on managing the problems existing among the elderly and monitoring their psychological state. Establishing educational programs on how to focus on the psychological and physical aspects. In addition, increasing leisure trips to various places.