The Predictive Role for ST2 in Patients with Acute Coronary Syndromes and Heart Failure

Tsigkou, Vasiliki; Siasos, Gerasimos; Bletsa, Evanthia; Panoilia, Maria Evi; Papastavrou, Angeliki; Kokosias, Georgios; Oikonomou, Evangelos; Papageorgiou, Nikolaos S.; Zaromitidou, Marina; Μαρίνος, Γεώργιος; Vavuranakis, Manolis; Stefanadis, Christodoulos; Papavassiliou, Athanasios G.; Tousoulis, Dimitris

doi:10.2174/0929867326666191016121630

Cited by 12 publications

(8 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One is membrane-bound form ST2 (ST2L), which can bind to IL-33, playing a role in preventing hypertrophy and fibrosis and modulation of Th1/Th2; while the other is sST2, which acts as a decoy receptor, binding to free IL-33 and blocking ST2/IL-33 signaling (10,11). Many studies have shown that soluble ST2 is associated with the development of cardiovascular disease (CVD) such as aortic dissection, heart failure, acute coronary syndrome and atrial fibrillation (12)(13)(14)(15). The presence of inflammatory cells in coronary plaques from patients with UAP provides the basis for the atherosclerotic inflammatory hypothesis that was supported by plenty of evidence (16,17).…”

Section: Rationale and Knowledge Gapmentioning

confidence: 99%

“…Further studies targeting people at low cardiovascular risk are needed to verify whether the specificity of this new model could be further confirmed. in patients with unstable angina and chronic coronary syndrome (14,24,25). High-density lipoprotein cholesterol (HDL-C), a variety of lipoproteins with mean size of 8-10 nm and density of 1.063-1.21 g/mL, not only acts as lipid transporters that transport cholesterol reversely, but also carries a variety of proteins and microRNAs.…”

Section: What Is the Implication And What Should Change Now?mentioning

confidence: 99%

See 1 more Smart Citation

Effect of combining sST2/HDL-C ratio with risk factors of coronary heart disease on the detection of angina pectoris in Chinese: a retrospective observational study

Zhang¹,

Zhang²,

Chen³

2023

Cardiovasc Diagn Ther

View full text Add to dashboard Cite

Background: Soluble suppression of tumorigenicity 2 (sST2), a member of the interleukin-1 receptor family, binds IL-33, preventing its interaction with membrane-bound form ST2 (ST2L), thereby blocking its protection against atherosclerosis. High-density lipoprotein cholesterol (HDL-C), a variety of lipoproteins with mean size of 8-10 nm and density of 1.063-1.21 g/mL, not only acts as lipid transporters that transport cholesterol reversely, but also carries a variety of proteins and microRNAs endowing it with the ability to prevent cardiovascular disease. Most studies on the relationship between sST2 and coronary heart disease (CHD) are limited to acute myocardial infarction (AMI). The present study set out to investigate the association between the sST2/HDL-C ratio and angina pectoris.Methods: A retrospective single-center cohort study was conducted and a total of 250 patients with chest pain that formed a convenience series, hospitalized between January 2018 and August 2020, were enrolled.Patients with AMI, acute and chronic heart failure, structural heart disease, renal insufficiency [estimate glomerular filtration rate (eGFR) <60 mL/min/1.73 m 2 ], rheumatic immune diseases, malignant tumors and severe infections were excluded. Patients with missing data were also excluded. Two hundred and nine patients were finally enrolled. Levels of sST2, HDL-C and sST2/HDL-C ratio were measured and calculated after admission. The angina pectoris was diagnosed by combining clinical features, coronary angiography results and cardiac troponin I levels. The diagnosis value of sST2/HDL-C on angina pectoris was analyzed by binary logistic analysis and the receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) assesses.Results: Patients with stable angina pectoris (SAP) or unstable angina pectoris (UAP) accounted for a larger proportion (28.8% vs. 42.9%, P=0.035) in patients with the higher sST2/HDL-C ratio. Binary logistics regression showed that for every unit of sST2/HDL-C increase, the risk of angina pectoris increased by 38.8% (OR =1.388, P=0.018). By subgroup analysis, a stronger association was found in nondiabetic patients (OR =1.551, P=0.006), non-hypertension patients (OR =1.700, P=0.025), non-smokers (OR =1.527, P=0.049) and patients aged <65 y (OR =1.693, P=0.019). ROC curve showed that AUC was higher [0.643 (0.566, 0.719) vs. 0.618 (0.540, 0.696)] and the sensitivity of diagnosis increased significantly (84.0% vs. 49.3%) by combining sST2/HDL-C with risk factors of CHD.Conclusions: A higher ratio of sST2/HDL-C was associated with an increased risk of angina pectoris. sST2/HDL-C combined with CHD risk factors showed increased diagnostic value in identifying angina pectoris.

show abstract

Section: Rationale and Knowledge Gapmentioning

confidence: 99%

Section: What Is the Implication And What Should Change Now?mentioning

confidence: 99%

Effect of combining sST2/HDL-C ratio with risk factors of coronary heart disease on the detection of angina pectoris in Chinese: a retrospective observational study

Zhang¹,

Zhang²,

Chen³

2023

Cardiovasc Diagn Ther

View full text Add to dashboard Cite

show abstract

“…Myocardial fibrosis is a hallmark pathological change after myocardial injury, which features excessively high extracellular matrix (ECM) production that contributes to degrading the normal tissue architecture 1 . Myocardial fibrosis is tightly associated with reduced patient survival in heart failure (HF), 2 but its exact mechanism has not been fully clarified, while effective antifibrotic treatment approaches are lacking 3,4 . Of note, cardiac fibroblasts (CFs), as a major cardiac cell type in mammalians, play important roles during cardiac fibrosis 5 …”

Section: Introductionmentioning

confidence: 99%

MicroRNA‐338‐3p as a therapeutic target in cardiac fibrosis through FGFR2 suppression

Huang

Wang

et al. 2022

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background The development of cardiac fibrosis involves the activation of cardiac fibroblasts (CFs) and their differentiation into myofibroblasts, which leads to the disruption of the extracellular matrix network. In the past few years, microRNAs (miRNA) have been described as potential targets for treating cardiac diseases. Although miR‐338‐3p has been shown to participate in the development of carcinoma, whether it affects cardiac fibrosis is unclear. Methods We examined the expression profiles of microRNAs in left ventricular samples of heart failure mice established by thoracic aortic constriction (TAC). Real‐time quantitative reverse transcription polymerase chain reaction (qRT‐PCR) was used to detect the expression of miR‐338‐3p. CCK‐8 assay/Transwell migration assay was used to measure the proliferation rate/migration of CFs. Luciferase reporter gene assay was used to test the binding between miR‐338‐3p and FGFR2. Results This study demonstrated that miR‐338‐3p was significantly decreased in thoracic aortic constriction mice. Cardiac miR‐338‐3p amounts were also reduced in patients with dilated cardiomyopathy (DCM). Interestingly, miR‐338‐3p overexpression inhibited α‐SMA, COL1A1, and COL3A1 expression, as well as cell proliferation and migration in CFs. Bioinformatics analysis and dual‐luciferase reporter assays revealed FGFR2 was targeted by miR‐338‐3p, whose antifibrotic effect could be alleviated by overexpression of FGFR2. Moreover, in DCM cases, serum miR‐338‐3p levels were markedly elevated in individuals with worse outcomes. Conclusions The present study provides evidence that miR‐338‐3p suppresses cardiac fibroblast activation, proliferation, and migration by directly targeting FGFR2 in mice. Besides, serum miR‐338‐3p might constitute a potential prognostic biomarker of dilated cardiomyopathy.

show abstract

“…CSF/NRF has been confirmed to be related to heart failure, arrhythmia, and long-term mortality [ 3 ]. Soluble growth stimulator gene 2 protein (sST2) is secreted by cardiomyocytes and fibroblasts under mechanical stress stimulation and/or cardiovascular stress [ 4 ]. A higher level of sST2 is associated with a poor prognosis of myocardial infarction.…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of Soluble Growth Stimulator Gene 2 Protein for Coronary Slow Flow/No-Reflow in ST-Elevation Myocardial Infarction Patients Receiving Percutaneous Coronary Intervention

Chang

Luan

et al. 2022

Journal of Interventional Cardiology

View full text Add to dashboard Cite

Background. Soluble growth stimulator gene 2 protein (sST2) is associated with heart failure and myocardial infarction; however, the predictive value of plasma sST2 level for coronary slow flow/no-reflow (CSF/NRF) is unclear. This study aimed to explore the predictive value of plasma sST2 levels for CSF/NRF in patients with ST-elevation myocardial infarction (STEMI) who underwent emergency percutaneous coronary intervention (PCI). Methods. A total of 242 STEMI patients who underwent emergency PCI at our hospital between November 2020 and July 2021 were enrolled in this study. According to the postprocedural procedure, these patients were divided into the CSF/NRF and control groups. Clinical data were collected from both groups and were used to explore the predictive value of serum sST2 levels for CSF/NRF. Results. Of the total 242 patients, CSF/NRF was observed in 50 patients (20.7%). Statistically significant differences ( P < 0.05 ) were observed in age, diabetes mellitus, sST2 level, neutrophil-to-lymphocyte ratio (NLR), fasting blood sugar, preprocedural blood pressure, intraprocedural hypotension, N-terminal pro-B-type natriuretic peptide, MB isoenzyme of creatine kinase (CK-MB), and cardiac troponin I (cTNI). Multivariate analysis showed that the sST2 level, NLR, and intraoperative hypotension were independent risk factors for CSF/NRF. ROC curve analysis showed that the sensitivity and specificity of the sST2 level for predicting CSF/NRF were 68.0% and 75.5%, respectively, when the sST2 level was more than 64.6 ng/mL (AUC = 0.780, 95% CI: 1.003–1.020, P = 0.009 ). Conclusion. For STEMI patients, preprocedural sST2 levels significantly correlated with CSF/NRF occurring in PCI. sST2 level is a potential predictor for CSF/NRF occurrence.

show abstract

The Predictive Role for ST2 in Patients with Acute Coronary Syndromes and Heart Failure

Cited by 12 publications

References 97 publications

Effect of combining sST2/HDL-C ratio with risk factors of coronary heart disease on the detection of angina pectoris in Chinese: a retrospective observational study

Effect of combining sST2/HDL-C ratio with risk factors of coronary heart disease on the detection of angina pectoris in Chinese: a retrospective observational study

MicroRNA‐338‐3p as a therapeutic target in cardiac fibrosis through FGFR2 suppression

Predictive Value of Soluble Growth Stimulator Gene 2 Protein for Coronary Slow Flow/No-Reflow in ST-Elevation Myocardial Infarction Patients Receiving Percutaneous Coronary Intervention

Contact Info

Product

Resources

About