The predictive role of monocyte-lymphocyte ratio and plateletlymphocyte ratio in postmenopausal osteoporosis

Abstract

Objective. To investigate the relationship between neutrophil to lymphocyte ratio (NEU/LY), monocyte to lymphocyte ratio (MO/LY), platelet to lymphocyte ratio (PLT/LY), mean platelet volume to lymphocyte ratio (MPV/LY), mean platelet volume to platelet ratio (MPV/PLT), plateletcrit to platelet ratio (PCT/PLT) and postmenopausal osteoporosis. Materials and Methods. The data of the patients who were admitted to Ümraniye Training and Research Hospital between January 2017 and July 2020 and had both bone mineral densitometry and hemogram tests on the same day were retrospectively scanned. A number of 177 patients who had been in natural menopause for at least one year and did not have any chronic disease nor used any medication were first divided into 3 groups: a number of 48 patients with osteoporosis, 103 with osteopenia and 26 patients included in the control group. Later on, 177 patients were divided into two groups: 151 patients with low bone mineral density and 26 patients were included in the control group. Results. There was no difference between the three groups in terms of NEU/LY, MPV/LY, MPV/PLT and PCT/PLT. The MO/LY ratio and PLT/LY ratio were statistically significantly higher in the osteoporosis group (p = 0.002, p <0.001, respectively). The MO/LY ratio was significantly higher in the group with low bone mineral density compared to the control group (p = 0.011), while there was no statistical difference between the two groups in terms of PLT/LY ratio (p = 0.281). Conclusions. This study shows that MO/LY and PLT/LY are quite simple and cheap markers that can be used in the diagnosis of postmenopausal osteoporosis and MO/LY in the diagnosis of postmenopausal low bone mineral density.

Associations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Osteoporosis: A Meta-Analysis

“…Of these studies, 14 were excluded for the following reasons: full texts were not available for three studies, two were non-related studies investigating topics out of interest, eight studies did not provide data on NLR or PLR, and one study provided significant outlying NLR value, which was significantly higher for our target population. The remaining ten studies were included in the meta-analysis [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. All the included studies were published in English.…”

“…The ten studies were all cross-sectional design, published between 2009 and 2021, conducted in China, Korea, Oman, and Turkey, and comprised 2616 individuals (1830 with osteoporosis, 786 with normal BMD) in total. Six studies comprised only postmenopausal women [ 17 , 18 , 20 , 21 , 25 , 26 ], and the other four studies included adults with no restrictions on sex [ 19 , 22 , 23 , 24 ]. Most studies measured bone mineral density by using dual energy X-ray absorptiometry, and recorded as T-score; measured sites included lumbar spine, pelvis, femoral neck, proximal femur, and total femur.…”

“…Most studies measured bone mineral density by using dual energy X-ray absorptiometry, and recorded as T-score; measured sites included lumbar spine, pelvis, femoral neck, proximal femur, and total femur. All studies provided data on NLR in both the osteoporosis and normal BMD groups; five studies provided data on PLR [ 17 , 18 , 19 , 21 , 22 ].…”

“…The methodological quality of the included studies was assessed using the modified NOS, with results shown in Supplementary Materials (Table S1) . Of the ten studies, eight were determined to be high quality [ 18 , 19 , 21 , 22 , 23 , 24 , 25 , 26 ]; the remaining two studies were regarded as moderate quality due to poor baseline control for potential confounders of NLR and PLR [ 17 , 20 ].…”

“…In subgroup analysis, we furtherly analyzed the difference in NLR between the osteoporosis and normal BMD groups in postmenopausal women. Six of the included studies provided NLR data in both groups and involved postmenopausal women only [ 17 , 18 , 20 , 21 , 25 , 26 ]. The pooled results showed that NLR was significantly higher in the osteoporosis group (MD = 0.432, 95% CI: 0.309–0.554, p < 0.0001; Figure 3 ), with low heterogeneity detected across the included studies ( I 2 : 0%, p = 0.497; Figure 3 ).…”