The predictive value and correlation of β-catenin, CMTM6, and PD-L1 expression in colorectal cancer

Abstract

CMTM6, and PD-L1 immunohistochemical expression in is CRC still unknown and need to be further verified. We evaluated t -catenin, CMTM6, PD-L1, and MMR (mismatch repair) proteins by immunohistochemistry in CRC tissue microarray (TMA), and -catenin, CMTM6, PD-L1 expression, MMR status, and clinicopathological features in 704 CRC patients. Positive expression of PD-L1 in tumor cells (TC) is associated with more frequent dMMR (mismatch repair deficient) status, CMTM6 expression, right colon, and younger CRC patients. The expression of PD-L1 in tumor-infiltrating immune cells -catenin, and CMTM6 expression. In univariate analysis, age, histological subtype, histologic grade, lymphatic metastasis, TNM stage, MMR status, and expression of PD-L1 protein in IC were significantly associated with the overall survival. In multivariate analysis, age, histologic grade, TNM stage, MMR status, and expression of PD-L1 protein in IC were independent prognostic factors. The overall survival of the adjuvant chemotherapy group was significantly higher than those non-chemotherapy in TNM stage III-IV CRC patients, but no significant overall survival improvement was found in the positive PD-L1 in TC, positive PD--catenin expression, or dMMR status subgroups. Expression of CMTM6 and PD--catenin and reliable biomarkers for the prediction of responding to chemotherapy. The expression of -catenin/CMTM6/PD-L1 and MMR status may be valuable biomarkers for guiding different treatment strategies in CRC patients.

Molecular and immunological characteristics of patients with CMTM6 low expression colorectal cancer

“…Although previous studies have shown that CMTM6 and PD-L1 are both highly expressed in CRC tissues and exhibit a positive correlation, research on the expression of CMTM6 in CRC and its relationship with PD-L1 expression and immune infiltration remains limited. [ 7 ] Therefore, the aim of this study was to investigate the expression of CMTM6 in CRC and its relationship with PD-L1 expression and immune infiltration by utilizing CRC patient data from the Cancer Genome Atlas (TCGA) database and employing bioinformatics methods. Additionally, enrichment analysis will be conducted to explore the relationship between CMTM6 and biological processes and pathways in CRC.…”