The predictive value of creatinine clearance for mortality in patients undergoing revascularization

Ram, Eilon; Beckerman, Pazit; Segev, Amit; Nir, Shlomo; Atlas-Lazar, Abigail; Sternik, Leonid; Raanani, Ehud

doi:10.1186/s13019-021-01502-1

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…Chronic kidney disease (CKD) and coronary artery disease (CAD) are strongly associated. 1 CKD is a well-known risk factor for the development and progression of CAD, 2,3 and adversely affects outcomes in patients with CAD. [4][5][6][7][8][9] Low estimated glomerular filtration rate (eGFR) is associated with an increasing risk of all-cause mortality in patients with CAD.…”

Section: Introductionmentioning

confidence: 99%

Prediction of Outcomes Through Cystatin C and cTnI in Elderly Type 2 Myocardial Infarction Patients

Ma,

Bian,

Gao

2023

CIA

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Background Chronic kidney disease (CKD) and coronary artery disease (CAD) are strongly associated. Cystatin C (Cys C) is a more sensitive marker of early renal insufficiency. This study aimed to evaluate the prognostic implications of combined of Cys C and cardiac troponin I (cTnI) on 90-day outcomes in elderly patients with type 2 myocardial infarction (MI). Methods The data of consecutive type 2 MI patients aged 80 years and older who received Cys C and cTnI measurements within 24 h of admission were retrospectively reviewed. The endpoint was a 90-day all-cause and cardiac mortality. Results A total of 4326 patients were included. During the 90-day follow-up period, a higher all-cause and cardiac mortality was observed in patients with Cys C ≥ 1.49mg/L than in patients with Cys C < 1.49 mg/L (P <0.001). After the multivariate logistic regression adjustments, the higher CysC and cTnI levels remained independent predictors of the 90-day all-cause mortality and cardiac mortality. Moreover, the Kaplan–Meier all-cause and cardiac mortality event-free survival curves showed that the patients with the presence of elevated levels of both Cys C and cTnI had a significantly increased risk than those with Cys C or cTnI alone. Conclusion Elevated Cys C level is an independent risk factor for all-cause and cardiac mortality in the elderly type 2 MI population. The predictive ability of the combined use of Cys C and cTnI in elderly type 2 MI patients is stronger than that of Cys C or cTnI alone.

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