The predictive value of elevated neutrophil to lymphocyte ratio for long-term cardiovascular mortality in peripheral arterial occlusive disease

Ertürk, Mehmet; Çakmak, Hüseyin Altuğ; Surgit, Özgür; Çelik, Ömer; Aksu, Hale Ünal; Akgül, Özgür; Gürdoğan, Muhammet; Bulut, Ümit; Ozalp, Begum; Akbay, Ertan; Yildirim, Aydın

doi:10.1016/j.jjcc.2014.02.019

Cited by 83 publications

(68 citation statements)

References 33 publications

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“…In medical inpatients with multiple chronic conditions, increased NLR was associated with mortality [21]. In patients with peripheral arterial occlusive disease, increased NLR was related with higher cardiovascular mortality [22]. Okyay et al [23] noted that laboratory measurement of NLR, which is relatively easy and inexpensive, might provide significant information regarding inflammation in CKD, including in predialysis and dialysis patients.…”

Section: Discussionmentioning

confidence: 99%

High Neutrophil-to-Lymphocyte Ratio is a Significant Predictor of Cardiovascular and All-Cause Mortality in Patients Undergoing Peritoneal Dialysis

Wang

Zhang

et al. 2018

Kidney Blood Press Res

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Background/Aims: Chronic inflammation is associated with increased risk of cardiovascular death in patients with end-stage renal disease (ESRD). Although elevated neutrophil-tolymphocyte ratio (NLR), a novel inflammatory marker, has been shown to predict cardiovascular disease and all-cause mortality in the general population, limited evidence is available for its role in ESRD. Methods: We enrolled 86 patients undergoing peritoneal dialysis (PD) for a 36-month follow-up to investigate the association between the NLR and arterial stiffness markers, namely, carotid-femoral pulse wave velocity (cfPWV) and carotid augmentation index (AIx), and mortality in PD patients. The primary endpoints were cardiovascular mortality and all-cause mortality. Kaplan-Meier curves were used to show the cumulative incidence of cardiovascular mortality and all-cause mortality. Results: High NLR was found to be a predictor of increased cfPWV (β = 1.150; P < 0.001) and AIx (β = 3.945; P < 0.001) in patients on PD. Patients with higher NLR had lower survival during follow-up. Kaplan-Meier curves showed that the cumulative incidences of both cardiovascular mortality and all-cause mortality were significantly higher in patients with NLR ≥ 4.5 (both P < 0.01). Conclusion: Our results suggest that high NLR is independently associated with arterial stiffness and predicts cardiovascular and all-cause mortality in PD patients.

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Section: Discussionmentioning

confidence: 99%

High Neutrophil-to-Lymphocyte Ratio is a Significant Predictor of Cardiovascular and All-Cause Mortality in Patients Undergoing Peritoneal Dialysis

Wang

Zhang

et al. 2018

Kidney Blood Press Res

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“…In the present study, the cutoff value for NLR was set as 2.81 based on the ROC value used in the cardiac study performed in our hospital [11]; in other studies, it has been reported as 2.72 and 3 [34,35]. NLR has been considered as a good marker in the prediction of the outcomes in cardiac diseases [31][32][33][34][35][36]. Similarly, high NLR value was found to be an independent predictor of CAE development based on both univariate and multivariate analyses.…”

Section: Neutrophil-to-lymphocyte Ratio (Nlr)mentioning

confidence: 99%

Hematological predictors and clinical outcomes in cardiac surgery

et al. 2016

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“…5,6 Unlike TNF-alpha and IL-6, which require separate tests, NLR can be readily calculated from a patient's full blood count without incurring additional cost. NLR has been identified as a marker of systemic inflammation and prognostic marker for mortality in patients with solid organ malignancies, 7 peripheral vascular disease, 8,9 and in the setting of acute coronary syndrome. 10,11 Despite this, few studies have investigated the prognostic value of NLR in patients with chronic kidney disease, with none focusing solely on hemodialysis patients.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil–lymphocyte ratio predicts cardiovascular and all-cause mortality in hemodialysis patients

et al. 2015

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Neutrophil-lymphocyte ratio (NLR) is a marker of systemic inflammation that has been shown to predict mortality in patients with malignancies, ischemic heart disease and peripheral vascular disease. Its prognostic value in hemodialysis patients is unclear. The aims of this study were to: (i) explore the relationship between NLR and other biochemical parameters and (ii) to examine the value of NLR as a predictor of cardiovascular and all-cause mortality in hemodialysis patients. The study included all the incident hemodialysis patients from a single center between 2007 and 2012. NLR was calculated using samples obtained 3 months after commencing hemodialysis. One hundred seventy hemodialysis patients were included with a median follow-up of 37 months. There were 54 deaths (32%). NLR was positively correlated with C-reactive protein (r ¼ 0.24, p ¼ 0.0023) and negatively correlated with hemoglobin (r ¼ À0.27, p ¼ 0.00048), albumin (r ¼ À0.23, p ¼ 0.0034) and total cholesterol (r ¼ À0.17, p ¼ 0.049) levels. In multivariate Cox regression, NLR was independently associated with both all-cause mortality (adjusted hazard ratio [HR] 1.4; 95% confidence interval [CI], 1.2-1.6; p 0.0001) and cardiovascular death (HR 1.3, 95% CI 1.1-1.6, p ¼ 0.0032). Other predictors of all-cause mortality were age (HR 1.6 per decade; 95% CI, 1.2-2.1; p ¼ 0.0017), body mass index (HR 0.93; 95% CI, 0.88-0.98; p ¼ 0.0047), albumin (HR 0.91; 95% CI, 0.86-0.97; p ¼ 0.0035) and peripheral vascular disease (HR 2.7; 95% CI, 1.4-5.1; p ¼ 0.0023). NLR is a practical, cost-efficient and easy to use predictor of cardiovascular and all-cause mortality in incident hemodialysis patients.

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The predictive value of elevated neutrophil to lymphocyte ratio for long-term cardiovascular mortality in peripheral arterial occlusive disease

Cited by 83 publications

References 33 publications

High Neutrophil-to-Lymphocyte Ratio is a Significant Predictor of Cardiovascular and All-Cause Mortality in Patients Undergoing Peritoneal Dialysis

High Neutrophil-to-Lymphocyte Ratio is a Significant Predictor of Cardiovascular and All-Cause Mortality in Patients Undergoing Peritoneal Dialysis

Hematological predictors and clinical outcomes in cardiac surgery

Neutrophil–lymphocyte ratio predicts cardiovascular and all-cause mortality in hemodialysis patients

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