The Predictive Value of Fatigue for Nonfatal Ischemic Heart Disease and All-Cause Mortality

Ekmann, Anette; Osler, Merete; Avlund, Kirsten

doi:10.1097/psy.0b013e318258d294

Cited by 23 publications

(23 citation statements)

References 30 publications

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“…Although not consistent across all CHD studies, others have reported that fatigue is associated with sex, age, health related quality of life (HRQoL), medication type, smoking status, pain, and depressed mood (DeVon, Ryan, Ochs, & Shapiro, 2008;Ekmann, Osler, & Avlund, 2012;Fink et al, 2009;Fink et al, 2012;Hagglund, Boman, Stenlund, Lundman, & Brulin, 2008;McSweeney& Crane, 2000;Shaffer et al, 2012).…”

Section: Organizing Frameworkmentioning

confidence: 99%

“…Among patients (N = 256, mean age 67 years) presenting to the emergency department for ACS, patients reported that 'unusual fatigue' was one of the 3 most prevalent symptoms that propelled them to seek care (DeVon, Ryan, Ochs, & Shapiro, 2008). In a large prospective study enrolling only men (N = 5,216, mean age 59 years), Ekmann et al (2012) found that fatigue was associated with first hospitalization for nonfatal ischemic heart disease (hazard ratio [HR] = 1.98, 95% confidence interval [CI] = 1.09-3.61) and all-cause mortality (HR = 3.99, 95% CI = 2.27-7.02). After adjusting for smoking and alcohol consumption, fatigue remained the only significant predictor of first hospitalization for nonfatal ischemic heart disease in men.…”

Section: Fatigue In the Presence Of Coronary Heart Diseasementioning

confidence: 99%

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Fatigue in the Presence of Coronary Heart Disease

et al. 2014

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Section: Organizing Frameworkmentioning

confidence: 99%

Section: Fatigue In the Presence Of Coronary Heart Diseasementioning

confidence: 99%

Fatigue in the Presence of Coronary Heart Disease

et al. 2014

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“…Symptoms of depression, anxiety, specific personality traits, and fatigue have all been shown to predict the onset of CVD and the prognosis in patients with established CVD, independent of traditional biomedical risk factors [13][14][15][16][17][18][19][20][21]. A recent meta-analysis based on 20 studies examining the predictive value of anxiety for the incidence of coronary heart disease in originally healthy individuals found that anxious people had a 26% increased risk of developing coronary heart disease and a 48% increased risk of cardiac death [14].…”

Section: Psychological Distress (D)mentioning

confidence: 99%

“…Negative affect is the tendency to experience negative emotions, whereas social inhibition is the tendency to inhibit emotions and to experience a high level of insecurity in social encounters [22]. Also fatigue is predictive of new onset CVD in healthy individuals [16,17] and coronary artery disease in CVD patients [18]. The psychosocial risk factor that has been studied the most is depression, with evidence pointing to a relation between depression and the development of new onset CVDs, such as heart failure [19,20], increased risk of major adverse cardiac events [20,21], and cardiac death in patients with established CVD [19].…”

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confidence: 99%

Cardiovascular co-morbidity in cancer patients: the role of psychological distress

et al. 2016

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Due to aging of the population and cardiotoxic cancer treatment, there is an increasing group of patients with cancer and co-morbid cardiovascular disease (CVD). In order to find a balance between the risk of undertreating the malignancy on the one hand and inducing CVD on the other hand, CVD risk stratification at the time of cancer diagnosis and knowledge on the pathway for developing incident CVD in cancer patients is vital. In this paper, we propose an adapted multiple-hit hypothesis for developing CVD in cancer patients describing that patients with cancer are exposed to a series of sequential or concurrent events that together make them more vulnerable to reduced cardiovascular reserves, development of incident CVD and ultimately death. We highlight the possible impact of psychological distress secondary to a cancer diagnosis and/or treatment, which in turn may increase the risk of incident CVD in patients diagnosed with cancer. Furthermore, we discuss potential behavioral and pathophysiological mechanisms underlying the link between psychological distress and the pathophysiology of incident CVD. In addition, key unanswered questions for future research are posed. In the future, researching the adapted multiple-hit hypothesis for developing CVD among cancer patients will hopefully advance the care of cancer patients by finding some of the missing pieces of the puzzle. To do so, we need to focus on minimizing cardiovascular risk and promoting cardiovascular health in cancer patients by addressing the knowledge gaps formulated in this paper.Keywords: Cancer, Survivors, Cardiovascular, Psychological distress, Mechanisms Cardiovascular co-morbidity in cancer patientsDue to aging of the population, there is an increasing number of patients with cancer and co-morbid cardiovascular disease (CVD). Additionally, cancer patients may develop incident CVD as a result of the cardiotoxicity of cancer treatment. Fortunately, there has been increasing awareness of co-morbid CVD in cancer patients. In 2009, the International CardiOncology Society (ICOS) was established [1]. ICOS advocates a multi-disciplinary effort to combat CVD in cancer patients by both training oncologists and cardiologists and conducting multidisciplinary research. In 2014, during the international colloquium on cardio-oncology, ICOS stressed the importance of finding a balance between the risk of undertreating the malignancy on the one hand and inducing CVD by overtreating on the other hand [2]. In order to accomplish this goal, they emphasize the importance of CVD risk stratification at the time of cancer diagnosis. Recommendations based on consensus have also been published to target the vulnerable cancer patient population, emphasizing the importance of a thorough cardiac evaluation, including the assessment of risk factors, prior to formulating a cancer treatment plan [3].Adapted multiple-hit hypothesis: the impact of psychological distress Important in CVD risk stratification is knowledge of the pathway for developing CVD in cancer patie...

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“…In addition, it has been shown that mobility and energy may be the most discriminating components of the frailty construct (30). A recent study indicated that fatigue in healthy middle-aged adults might be a marker of subsequent hospitalization due to first nonfatal ischemic heart disease (IHD) among nonsmokers (20). It was suggested that unexplained fatigue may be an early sign of age-related declining cardiovascular functioning and, hence, increased vulnerability of developing age-related IHD (20).…”

mentioning

confidence: 99%