The Predictive Value of Myoglobin for COVID-19-Related Adverse Outcomes: A Systematic Review and Meta-Analysis

Ma, Chaoqun; Tu, Dingyuan; Gu, Jin; Xu, Qiang; Hou, Ping; Wu, Hong; Guo, Zhixin; Bai, Yuan; Zhao, Xianxian; Li, Pan

doi:10.3389/fcvm.2021.757799

Cited by 16 publications

(23 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For non-vaccinated groups, the present study showed that Myoglobin was significantly higher (P<0.0001) in individuals infected with CoV-19 virus and non-vaccinated more than patients that non-vaccinated and recovery from covid-19 as indicated in the Figure 5. The current results were compatible with the research of [49] that revealed the increased myoglobin was more prevalent in individuals with severe CoV-19 virus than in cardiac troponin I. Therefore, increased Mb may be used as a determinant of adverse COVID-19 outcomes.…”

Section: Estimation Of Serum Myoglobin Concentrationssupporting

confidence: 91%

Evaluation of some cardiac markers in relation to COVID-19 mRNA vaccine

Al-Azzawi¹,

AL-Eqabi²

2022

JBB

View full text Add to dashboard Cite

Background: Acute myocardial infarction (AMI) is a dangerous cardiovascular illness that has a significant impact on people's health. Several biomarkers, including Myoglobin and troponin I (cTnI) were utilized to diagnose AMI in recent decades. The Troponin I (cTnI) was designated as the "gold standard" cardiac biomarker for the prediction of cardiomyopathy. It's a heart muscle regulating protein found on normal myocyte actin filaments. When cardiac muscles are injured, cTnI, one of the main subunits of the cardiac troponin complex, is released into the circulation (e.g., myocardial infarction). Myoglobin denoted by (symbols Mb and MB) seems to be an iron-and o2-binding protein present in the vertebrate heart and skeletal muscle tissues and, more specifically, nearly all mammals. In humans, MB is only present in the bloodstream following muscle damage. Its primary function is to supply myocytes with oxygen. Also essential to nitric oxide hemostasis was myoglobin. Additionally, it facilitates the detoxification of response oxygen molecules from the body. MB is accountable for most vertebrate muscles' red hue.The aim: To assess the difference in the level of (MYOGLOBIN and TROPONIN_I) between patients with and without mRNA Vaccination. Methods: This study included 125 patients (65 male and 60 female) with vaccinated and non-vaccinated covid-19 with an age range of 20-69 years. These patients are divided into two main groups: 1. vaccinated (vaccinated with COVID-19 infection, vaccinated without COVID-19 disease, vaccinated recovered from the CoV-19 virus),2. unvaccinated (infected with the CoV-19 virus and non-vaccinated, recovered from covid-19 and unvaccinated). The outcome is measured using the Enzyme-linked immunosorbent assay (ELISA) technique. This study was conducted during the period from November 2021 to May 2022 at the Martyr Dr.

show abstract

Section: Estimation Of Serum Myoglobin Concentrationssupporting

confidence: 91%

Evaluation of some cardiac markers in relation to COVID-19 mRNA vaccine

Al-Azzawi¹,

AL-Eqabi²

2022

JBB

View full text Add to dashboard Cite

show abstract

“…Mortality & Severity ↑ (Kermali et al, 2020;Tian et al, 2020;Vakhshoori et al, 2020b;Toraih et al, 2020;Parohan et al, 2020;Shoar et al, 2020;Rathore et al, 2021;Alzahrani and Al-Rabia, 2021;Wibowo et al, 2021) TnT Li et al, 2020a;Parohan et al, 2020;Li et al, 2020c;Zheng et al, 2020;Ma et al, 2021;Zhu et al, 2021) NT Parohan et al, 2020;Li et al, 2020c;Shoar et al, 2020;Malik et al, 2021;Zhu et al, 2021) (Continued)…”

Section: Cardiac Troponinunclassified

COVID19 biomarkers: What did we learn from systematic reviews?

Semiz

2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

The coronavirus disease 2019 (COVID19) pandemic continues to represent a substantial public health concern. It can rapidly progress to severe disease, with poor prognosis and a high mortality risk. An early diagnosis and specific prognostic tools can help healthcare providers to start interventions promptly, understand the likely prognosis and to identify and treat timely individuals likely to develop severe disease with enhanced mortality risk. Here we focused on an impressive set of systematic reviews and meta-analyses that were performed since the start of the COVID19 pandemic and summarized their results related to the levels of hematologic, inflammatory, immunologic biomarkers as well as markers of cardiac, respiratory, hepatic, gastrointestinal and renal systems and their association with the disease progression, severity and mortality. The evidence outlines the significance of specific biomarkers, including inflammatory and immunological parameters (C-reactive protein, procalcitonin, interleukin-6), hematological (lymphocytes count, neutrophil-to-lymphocyte ratio, D-dimer, ferritin, red blood cell distribution width), cardiac (troponin, CK-MB, myoglobin), liver (AST, ALT, total bilirubin, albumin) and lung injury (Krebs von den Lungen-6) that can be used as prognostic biomarkers to aid the identification of high-risk patients and the prediction of serious outcomes, including mortality, in COVID19. Thus, these parameters should be used as essential tools for an early risk stratification and adequate intervention in improving disease outcomes in COVID19 patients.

show abstract

“…The tissue injury marker, myoglobin, and D-dimer levels have been used to predict the severity of COVID-19 patients. These biomarkers possess significant predictive potential in evaluating disease outcomes in COVID-19 patients [9] , [10] . The robust correlations of dysregulated GFs with these biomarkers may help identify whether aberrant levels of GFs in COVID-19 are pathological or compensatory.…”

Section: Introductionmentioning

confidence: 99%