The Predictive Value of NT-Pro-Brain Natriuretic Peptide for Risk of Pneumonia in Patients on Maintenance Hemodialysis

Guo, Ming; Cao, Xuesen; Shen, Bo; Geng, Xiwen; Chen, Rongyi; Gong, Shaomin; Ding, Xiaoqiang; Fei, Xiang; Zou, Jianzhou

doi:10.1159/000504524

Cited by 7 publications

(4 citation statements)

References 29 publications

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“…β2-MG is concerned with the presentation and stabilization of major histocompatibility complex (MHC) I antigen on the cell surface, which is important in adjusting antigen presentation and immunity [31] . It has been reported that β2-MG is an independent predictor of pulmonary infection in hemodialysis patients [32] , which was found increased in 9 of the 10 patients we reported, consistently. With the progress of treatment and the remission of conditions, β2-MG got back into normal range, and during this remission β2-MG showed positive moderate rank correlation to the CRP and PCT, which were signi cantly correlated to the disease severity as well.…”

Section: Discussionsupporting

confidence: 84%

Collective Outbreak of Severe Acute Histoplasmosis in Immunocompetent Chinese: The Clinical characteristics and Continuous Monitoring of Serum Cytokines/Chemokines

Peng

ShuLiang

Yan

et al. 2021

Preprint

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Background: Acute histoplasmosis is a rare fungal disease and is likely to be misdiagnosed in clinic. In this paper we attempted to find some easy potential specific diagnostic and disease severity predictors of acute histoplasmosis, on the basis of so far the biggest collective outbreak of severe acute histoplasmosis by inhaled fungi in Chinese. Methods: 10 immunocompetent Chinese were infected when they were working in Guyana, South America. Their clinic characteristics, as well as their blood samples were collected for analysis, and then Person rank correlation was employed to check the associations between the indicators and their clinic conditions. Results: At admission, their CRP, PCT, LDH and CysC were increased, CD4/CD8 was decreased (<1), and β2-MG was increased in 9 of them. For cytokines and chemokines, IL-4 was always <1.3pg/ml, and the IL-12, INF-a, TNF-a were always less than reference values. The results of Person rank correlation analysis showed that β2-MG, CysC, G-test, N/L, LDH were in positive associations to CRP, PCT, which were significantly correlated to the disease severity as well. Then IL-6, IL-8, IL-10 were in positive associations to CRP, PCT, β2-MG, CysC, G-test, N/L, and LDH, too. Conclusions: β2-MG, CysC, N/L, LDH, IL-6, IL-8, IL-10 may be reasonably potential diagnostic and disease severity predictors of acute histoplasmosis, but more examinations are still needed for further verification. More relevant indicators should also be taken into account for improving the accuracy of diagnosis and differential diagnosis.

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Section: Discussionsupporting

confidence: 84%

Collective Outbreak of Severe Acute Histoplasmosis in Immunocompetent Chinese: The Clinical characteristics and Continuous Monitoring of Serum Cytokines/Chemokines

Peng

ShuLiang

Yan

et al. 2021

Preprint

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“…Moreover, SRA1 upregulation exhibited a significant potential in diagnosing CHF patients, demonstrating high sensitivity and specificity in differentiating CHF patients from healthy individuals. Abnormal BNP levels, LAD, LVDd, and rLVEF volume are established diagnostic markers of CHF, and these parameters correspond to other pathogenetic factors, including respiratory failure, pneumonia, and chronic kidney dysfunction [ 22 , 23 , 24 , 25 , 26 ]. Additionally, a previous study demonstrated BNP and LVEF could predict the appropriate therapy and hospitalization in HF patients receiving internal cardioverter defibrillator (ICD) and identified a novel protein, soluble growth stimulation expression gene 2 protein (ST2) as a biomarker for the therapeutic efficiency of ICD [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Value of Plasma lncRNA SRA1 in Chronic Heart Failure

Yu,

Ge,

Cao

et al. 2024

Rev. Cardiovasc. Med.

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Background: The pathogenesis and development of chronic heart failure (CHF) may involve long non-coding ribonucleic acid (lncRNA) steroid receptor RNA activator 1 (SRA1), a known cardiomyopathy risk factor and regulator of cardiac myofibroblast activation. This study aimed to investigate the application of SRA1 in the early detection and prediction of CHF. Methods: SRA1 plasma expression was determined in CHF patients and healthy individuals/using real time-quantitative polymerase chain reaction (RT-qPCR). The diagnostic and prognostic value of SRA1 was assessed using receiver operating curve (ROC) and Cox regression analyses. Results: Compared with the healthy controls, the patients with CHF had increased brain natriuretic peptide (BNP) levels, left atrial end-systolic diameter (LAD), left ventricular end-diastolic diameter (LVDd), and decreased left ventricular ejection fraction (LVEF). SRA1 was significantly upregulated in CHF patients as well as positively correlated with BNP level, LAD, and LVDd, and negatively correlated with LVEF. SRA1 could sensitively discriminate CHF patients from healthy individuals and was an independent predictor of adverse event-free survival in CHF patients. Conclusions: Upregulated plasma SRA1 can discriminate patients with CHF from healthy individuals and predict adverse outcomes in CHF patients. Thus, SRA1 is a potential molecular indicator for monitoring chronic heart failure development.

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“…NT-proBNP is an inactive byproduct of proBNP cleavage that occurs under high filling pressures [17]. It remains stable at room temperature and increases to a higher level in pathological conditions [18,19]. Previous studies suggested that the serum NT-proBNP concentration could reflect the severity of right ventricular function injury, with a higher NT-proBNP level indicating a more severe CTEPH classification [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Expression of miR-93-5p as a Potential Predictor of the Severity of Chronic Thromboembolic Pulmonary Hypertension

Gong

Yang

Wang

et al. 2021

BioMed Research International

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Background. MicroRNAs (miRNAs) play an important role in the pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH). However, the potential correlation between miRNA expression and the severity of CTEPH remains unclear. Our previous study indicated that miRNAs hsa-let-7b-3p, hsa-miR-17-5p, hsa-miR-106b-5p, hsa-miR-3202, hsa-miR-665, and hsa-miR-93-5p are closely involved in CTEPH. This study assessed the associations between the expression levels of these miRNAs and clinical parameters in CTEPH patients. Methods. A total of eight CTEPH patients and eight healthy adults as a reference group were included, and clinical data including total protein (TP), albumin (Alb), lactate dehydrogenase (LDH), hydroxybutyrate dehydrogenase (HBDH), uric acid (UA), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were collected. Right heart catheterization was conducted to obtain hemodynamic data including cardiac index (CI). The expression levels of let-7b-3p, miR-17-5p, miR-106b-5p, miR-3202, miR-665, and miR-93-5p were measured by quantitative real-time PCR (qPCR). Correlation analysis was applied to estimate the associations between miRNA expression levels and clinical parameters in CTEPH patients. Results. Serum TP and Alb levels were decreased, while LDH, HBDH, and UA levels were increased in CTEPH patients compared with the reference group ( P < 0.05 ). miR-3202 and miR-665 were upregulated, whereas let-7b-3p, miR-17-5p, miR-106b-5p, and miR-93-5p were downregulated in CTEPH patients relative to the reference group ( P < 0.05 ). miR-93-5p expression was positively correlated with NT-proBNP level and negatively correlated with CI ( P < 0.05 ). Moreover, let-7b-3p tended to be positively correlated with mean pulmonary arterial pressure. Conclusions. miR-93-5p expression was associated with the severity of CTEPH and could act as a potential predictor of high-risk CTEPH.

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The Predictive Value of NT-Pro-Brain Natriuretic Peptide for Risk of Pneumonia in Patients on Maintenance Hemodialysis

Cited by 7 publications

References 29 publications

Collective Outbreak of Severe Acute Histoplasmosis in Immunocompetent Chinese: The Clinical characteristics and Continuous Monitoring of Serum Cytokines/Chemokines

Collective Outbreak of Severe Acute Histoplasmosis in Immunocompetent Chinese: The Clinical characteristics and Continuous Monitoring of Serum Cytokines/Chemokines

Diagnostic and Prognostic Value of Plasma lncRNA SRA1 in Chronic Heart Failure

Expression of miR-93-5p as a Potential Predictor of the Severity of Chronic Thromboembolic Pulmonary Hypertension

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