2024
DOI: 10.1186/s12865-023-00592-x
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The predictive value of peripheral blood CD4 cells ATP concentration for immune-related adverse events in advanced non-small cell lung cancer patients

Kailian Hou,
Weipeng Ye,
Qunfeng Huang
et al.

Abstract: Objective Lung cancer with the highest incidence and mortality in the world. Immune checkpoint inhibitors (ICIs), can bring long-term survival benefits to patients, but also can bring immune-related adverse events (irAEs) in some patients during therapy. Therefore, the aim of this study was to investigate the predictive effect of peripheral blood WBC, NLR, sATPCD4 and nATPCD4 on irAEs in advanced non-small cell lung cancer (NSCLC). Methods Clinical… Show more

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“…The levels of ATP released by stimulated (sATP CD4 ) and non-stimulated (nATP CD4 ) CD4 T lymphocytes were assessed through a luciferin-luciferase reaction, according to the manufacturer's instructions (AIMdex ® ; Leide Biosciences Co., Ltd.) ( 24 ). Briefly, 100 µl of 4-fold diluted whole blood was incubated with 8.75 ng/ml sATP or without phytohaemagglutinin (PHA; nATP) for 15–18 h,37°C.…”
Section: Methodsmentioning
confidence: 99%
“…The levels of ATP released by stimulated (sATP CD4 ) and non-stimulated (nATP CD4 ) CD4 T lymphocytes were assessed through a luciferin-luciferase reaction, according to the manufacturer's instructions (AIMdex ® ; Leide Biosciences Co., Ltd.) ( 24 ). Briefly, 100 µl of 4-fold diluted whole blood was incubated with 8.75 ng/ml sATP or without phytohaemagglutinin (PHA; nATP) for 15–18 h,37°C.…”
Section: Methodsmentioning
confidence: 99%