The predictive value of procalcitonin for postoperative early pancreatic fistula

Zhou, Quanyu; Xia, Yuxiao; Lei, Zehua

doi:10.1186/s12893-020-00755-2

Cited by 12 publications

(13 citation statements)

References 16 publications

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“…Six studies included analysis of postoperative day 3 procalcitonin analysis, 20–25 eight studies day 3 C‐reactive protein analysis. Five studies included analysis of CRP of day 4.…”

Section: Resultsmentioning

confidence: 99%

Postoperative serum procalcitonin versus C‐reactive protein as a marker of postoperative infectious complications in pancreatic surgery: a meta‐analysis

Vasavada

Patel

2021

ANZ Journal of Surgery

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Background Aim of this meta‐analysis was to compare diagnostic accuracy C‐reactive protein and procalcitonin between postoperative days 3 and 5 to predict infectious complications post pancreatic surgery. Methods A systemic literature search was performed using MEDLINE, EMBASE and SCOPUS to identify studies evaluating the diagnostic accuracy of procalcitonin and C‐reactive protein to predict infectious complications between postoperative days 3 and 5 following pancreatic surgery. A meta‐analysis was performed using random‐effect model and pooled predictive parameters. Results Fifteen studies consisting of 2212 patients were included in the final meta‐analysis. Pooled sensitivity, specificity, area under curve and diagnostic odds ratio (DOR) for day 3 C‐reactive protein were 62%, 67%, 0.772 and 6.54, respectively. Pooled sensitivity, specificity, area under curve and DOR for day 3 procalcitonin were 74%, 79%, 0.8453 and 11.03, respectively. Sensitivity, specificity, area under the curve and DOR for day 4 C‐reactive protein were 60%, 68%, 0.8022 and 11.90, respectively. Sensitivity, specificity and DOR of postoperative day 5 procalcitonin level for predicting infectious complications were 83%, 70% and 12.9, respectively. Pooled sensitivity, specificity, Area Under Receiver Operating Curve and DOR were 50%, 70%, 0.777 and 10.19, respectively. Conclusion Postoperative procalcitonin is a better marker to predict postoperative infectious complications after pancreatic surgeries.

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“…Six studies included analysis of postoperative day 3 procalcitonin analysis, 20–25 eight studies day 3 C‐reactive protein analysis. Five studies included analysis of CRP of day 4.…”

Section: Resultsmentioning

confidence: 99%

Postoperative serum procalcitonin versus C‐reactive protein as a marker of postoperative infectious complications in pancreatic surgery: a meta‐analysis

Vasavada

Patel

2021

ANZ Journal of Surgery

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“…compromise anastomotic healing. 19 Zhou et al 33 reported that there was no significant correlation between the abdominal surgery history and POPF. Hanna et al 34 found that antecolic gastrojejunostomy seems to be associated with less delayed gastric emptying, with no association with pancreatic fistula.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors and a New Prediction Model for Pancreatic Fistula After Pancreaticoduodenectomy

Zhang¹,

Huang²,

Zhao³

et al. 2021

RMHP

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In order to find the risk factors of postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD) according to the latest definition and grading system of International Study Group of Pancreatic Surgery (ISGPS) (version 2016) and propose a nomogram for predicting POPF. Methods: We conducted a retrospective analysis of 232 successive cases of PD performed at our hospital by the same operator from August 2012 to June 2020. POPF was diagnosed in accordance with the latest definition of pancreatic fistula from the ISGPS. The risk factors of POPF were analyzed by univariate and multivariate logistic regression analysis. A nomogram model to predict the risk of POPF was constructed based on significant factors. Results: There were 18 cases of POPF, accounting for 7.8% of the total. Among them, 17 cases were classified into ISGPF grade B and 1 case was classified into ISGPF grade C. In addition, 35 cases were classified into biochemical leak. Univariate and multivariate analysis showed that hypertension, non-diabetes, no history of abdominal surgery, antecolic gastrojejunostomy and soft pancreas were independent risk factors of POPF. Based on significant factors, a nomogram is plotted to predict the risk of POPF. The C-index of this nomogram to assess prediction accuracy was 0.916 (P < 0.001) indicating good prediction performance. Conclusion: Hypertension, non-diabetes, no history of abdominal surgery, antecolic gastrojejunostomy and soft pancreas were independent risk factors of POPF. Meanwhile, a nomogram for predicting POPF with good test performance and discriminatory capacity was constituted.

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“…[24]. Four included studies had infectious complications as their primary outcomes, while two [22,23] had pancreatic leak as its primary outcome.…”

Section: Resultsmentioning

confidence: 99%

Post-operative day 3 Procalcitonin predicts post-operative infectious complications in pancreatic surgery – A systemic review and updated meta-analysis

Vasavada

Patel

2020

Preprint

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Aim of study: Aim of this meta-analysis is to evaluate post-operative procalcitonin as a marker to predict post- operative infectious complications after pancreatic surgeries. Material and Methods: Systemic literature search was performed using MEDLINE, EMBASE and to identify studies evaluating the diagnostic accuracy of Procalcitonin (PCT) as a predictor for detecting infectious complications on postoperative days (POD) 3 and 5 following pancreatic surgery. A meta-analysis was performed using random effect model and pooled predictive parameters for POD 3 and 5 were derived. Geometric means were calculated for PCT cut offs. Results: 6 studies included day 3 PCT analysis, 2 studies included both day 3 and day 5 analysis. Total data of 471 patients were derived. 161 patients developed infectious complications. Pooled sensitivity, specificity, pooled area under curve, diagnostic odds ratio (DOR), positive and negative like hood ratio of day 3 PCT were 74%,79%,0.8453, 11.03,3.17 and 0.31 respectively. Pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive and negative like hood ratio of day 5 PCT were 83%,70%,12.91,2.91 and 0.25 respectively. Geometric means for PCT cut off for day 3 and 5 were 0.80 and 0.43. Conclusion: Postoperative procalcitonin particularly day 3 procalcitonin levels predict post-operative infectious complications following pancreatic surgeries.

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The predictive value of procalcitonin for postoperative early pancreatic fistula

Cited by 12 publications

References 16 publications

Postoperative serum procalcitonin versus C‐reactive protein as a marker of postoperative infectious complications in pancreatic surgery: a meta‐analysis

Postoperative serum procalcitonin versus C‐reactive protein as a marker of postoperative infectious complications in pancreatic surgery: a meta‐analysis

Risk Factors and a New Prediction Model for Pancreatic Fistula After Pancreaticoduodenectomy

Post-operative day 3 Procalcitonin predicts post-operative infectious complications in pancreatic surgery – A systemic review and updated meta-analysis

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