The predictive value of quantitative fibronectin testing in combination with cervical length measurement in symptomatic women

Bruijn, Merel; Kamphuis, Esmé I.; Hoesli, Irène; Tejada, Begoña Martínez de; Loccufier, Anne; Kühnert, Maritta; Helmer, Hanns; Franz, Marie; Porath, Martina; Oudijk, Martijn A.; Jacquemyn, Yves; Schulzke, Sven; Vetter, Gregor; Hoste, Griet; Vis, Jolande Y.; Kok, Marjolein; Mol, Ben Willem J.; Baaren, Gert Jan Van

doi:10.1016/j.ajog.2016.08.012

Cited by 47 publications

(35 citation statements)

References 21 publications

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“…There are publications comparing the predictive strength of qualitative and quantitative fFN measurements (16,17). A recent study showed that quantitative fFN test alone is equal effective to the combination of cervical length and qualitative fFN test (18). Although there is no statistically significance, the shorter cervical length was correlated with the higher likelihood of vaginal birth according to our results.…”

Section: Discussionsupporting

confidence: 49%

Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?

Çelik

Engin

Yıldırım

2020

Gynecol Obstet Reprod Med

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OBJECTIVE: Digital cervical evaluation has been used to determine the likelihood of vaginal delivery which is considered by many women to be non-tolerable. Recently, alternative approaches such as transperineal ultrasound, fetal fibronectin test in cervicovaginal secretions have been investigating for the prediction of the delivery route. We aimed to study whether the usefulness of qualitative fetal fibronectin test in cervicovaginal secretions for the prediction of vaginal delivery in pregnant women at postterm induced with dinoprostone. STUDY DESIGN:A total of 32 nulliparous pregnant women at postterm were enrolled in this prospective observational study. Fetal fibronectin test was applied to all participated women before the induction with dinoprostone and transvaginal ultrasonography was performed to measure cervical length. RESULTS:The women having positive fetal fibronectin test result gave birth through vaginal route, except one case. Although there is no statistically significant difference, the shorter cervical length was associated with vaginal delivery in our population. CONCLUSION:Fetal fibronectin test has a predictive value for delivery route in nulliparous women at postterm. Fetal fibronectin test may be used as a "rule out" test because the rate of fetal fibronectin positivity was found to be higher in patients who gave birth via vaginal route. As also shown in our study, although there is no statistically significant difference, the pregnant women with shorter cervical length might have a high possibility to achieve vaginal delivery.

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Section: Discussionsupporting

confidence: 49%

Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?

Çelik

Engin

Yıldırım

2020

Gynecol Obstet Reprod Med

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“…59 The combination of quantitative FFN testing and CL assessment may further increase predictive value, but data remains limited to preliminary observational studies. 62 The use of quantitative FFN remains investigational 63 and is not yet commercially available for use in the United States.…”

Section: Introductionmentioning

confidence: 99%

Predicting preterm birth: Cervical length and fetal fibronectin

Son

Miller

2017

Seminars in Perinatology

123

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Spontaneous preterm birth remains the leading cause of neonatal morbidity and mortality worldwide, and accounts for a significant global health burden. Several obstetric strategies to screen for spontaneous preterm delivery, such as cervical length and fetal fibronectin measurement, have emerged. However, the effectiveness of these strategies relies on their ability to accurately predict those pregnancies at increased risk for spontaneous preterm birth (SPTB). Transvaginal cervical shortening is predictive of preterm birth and when coupled with appropriate preterm birth prevention strategies, has been associated with reductions in SPTB in asymptomatic women with a singleton gestation. The use of qualitative fetal fibronectin may be useful in conjunction with cervical length assessment in women with acute preterm labor symptoms, but data supporting its clinical utility remain limited. As both cervical length and qualitative fetal fibronectin have limited capacity to predict preterm birth, further studies are needed to investigate other potential screening modalities.

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“…Indeed, we found that increased serum relaxin (> 1010 pg/mL) had a sensitivity of 58% for predicting preterm birth in women with a CL > 15 mm. In this context, the function of relaxin seems to be similar to that of cervicovaginal fibronectin, which is also not correlated with CL, and may improve the prediction of preterm birth in symptomatic women with a CL > 15 mm.…”

Section: Discussionmentioning

confidence: 97%

Serum relaxin and cervical length for prediction of spontaneous preterm birth in second‐trimester symptomatic women

Pantelis

Sotiriadis

Chatzistamatiou

et al. 2018

Ultrasound in Obstet & Gyne

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The predictive value of quantitative fibronectin testing in combination with cervical length measurement in symptomatic women

Cited by 47 publications

References 21 publications

Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?

Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?

Predicting preterm birth: Cervical length and fetal fibronectin

Serum relaxin and cervical length for prediction of spontaneous preterm birth in second‐trimester symptomatic women

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