The predictive value of total leukocyte count and leukocyte differential for severe preeclampsia

Bozdağ, Halenur; Bör, Ergül Demirçivi; Akdeniz, Esra

doi:10.2399/prn.18.0261007

Cited by 8 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A couple of other studies have also found a statistically significant association between high NLR values and PE, however, no statistically significant relationship was found between NLR and severity of PE in these studies (2,9). Some other studies, however, didn't find any statistically significant association between NLR and PE (7,10).…”

Section: Resultsmentioning

confidence: 84%

Raised neutrophil lymphocyte ratio and serum beta hCG level in early second trimester of pregnancy as predictors for development and severity of preeclampsia

Panwar

Kumari

et al. 2019

DD&T

View full text Add to dashboard Cite

Early detection and prediction of preeclampsia (PE) may avert serious materno-fetal complications. This prospective nested study was conducted to evaluate the role of serum beta human chorionic gonadotropin (hCG) and the neutrophil-lymphocyte ratio (NLR) in predicting the development and severity of PE. Four hundred and forty primigravidas, between 16 to 18 weeks of gestation, were recruited in the study. Serum beta-hCG and NLR were measured at the time of recruitment and they were followed and monitored for the development of PE and severe PE. Out of these 440 women, 64 (14%) developed PE; of which 25 (39%) developed severe PE. The mean values of NLR and serum beta hCG were significantly higher in patients developing PE and severe PE. NLR, with a cutoff value of 5.6, predicted the development of PE with 73.4% sensitivity and 88.6% specificity and severe PE with sensitivity 93.3% and specificity 86.6% respectively. The sensitivity and specificity of serum beta hCG in predicting the development of PE was 75% each for a cutoff value of 25,415 IU/mL whereas these values were 86.7%, and 79.1% respectively, for a cutoff value of 29,654 IU/mL for predicting the development of severe PE. These findings suggest that NLR and serum beta hCG can be used as excellent biomarkers in predicting both the development of PE and its severity. Multicentric studies involving subjects of multiple ethnicities should be done for establishing its utility as a routine screening test.

show abstract

Section: Resultsmentioning

confidence: 84%

Raised neutrophil lymphocyte ratio and serum beta hCG level in early second trimester of pregnancy as predictors for development and severity of preeclampsia

Panwar

Kumari

et al. 2019

DD&T

View full text Add to dashboard Cite

show abstract

“…. Boada et al [14], they found that the Leukocyte count was found significantly different among the three groups. Severe PE group had the highest median leukocyte count (12,100×1000 /μL).…”

Section: Discussionmentioning

confidence: 88%

“…There was significant elevation in RDW (P<0.001), significant reduction in NLR, (P<0.001), significant decrease in PLR, (P<0.001), significant reduction in MPV (P<0.001) and there was significant decrease in PCT (P=0.009). Boada et al [14], reported that leukocyte count was found significantly different among the three groups. Severe PE group had the highest leukocyte count (12,100×1000 /μL).…”

Section: Discussionmentioning

confidence: 89%

See 1 more Smart Citation

Study of Some Hematological Markers of Systemic Inflammatory Response in Preeclampsia

Abd-Elaziz

Elbasyuony

Mabrouk

et al. 2022

JAMMR

View full text Add to dashboard Cite

Background: Preeclampsia is one of the major health problems during pregnancy, which is characterized by hypertension, proteinuria, and features of multi-organ disease, and it complicates about 2 to 8% of pregnancies with increased maternal and neonatal morbidity and mortality, aim of this study was to evaluate the following blood markers in preeclampsia; neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, red cell distribution width, mean platelet volume and platelet value. Subjects and Methods: This was diagnostic research, observational method and cross-sectional design that was conducted at Obstetrics and Gynecology Department, Tanta University Hospitals, from 1-7-2020 to 1-11-2021. After fulfilling the Research and Ethics Committee guidelines, pregnant women were counseled to be enrolled in this study. Results: There was significant decrease in PLR in severe preeclampsia group compared to control group (P<0.001) as well as mild preeclampsia group (P<0.001); while there was no statistically significant difference between control group and mild preeclampsia group (P>0.05). There was significant elevation in RDW in severe preeclampsia group compared to control group (P=0.005) as well as mild preeclampsia group (P<0.001); There was significant reduction in MPV in severe preeclampsia group compared to mild preeclampsia group (P<0.001) as well as control group (P<0.001); while there was no statistically significant difference between mild preeclampsia group and control group (P>0.05). There was significant decrease in PCT in severe preeclampsia group compared to control group (P=0.034) as well as mild preeclampsia group (P=0.009); while there was no statistically significant difference between control group and mild preeclampsia group (P>0.05). Conclusion: In differentiation of preeclampsia, the highest sensitivity was achieved with MPV, while the highest specificity was achieved with PLR. In the differentiation of severe preeclamptic cases, the highest sensitivity was achieved with lymphocytes and MPV, while the highest specificity was achieved with PLR.

show abstract

“…NLR and MPV are increasingly used as indicators of cancer and various systemic diseases as well as systemic inflammation. Although there are studies on whether these parameters may have predictive value in cases such as preeclampsia, endometriosis, and tuba ovarian abscess in gynecology and obstetrics practice, there is no study on the value of these parameters in ICP (13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive for Gestational Cholestasis?

Eroğlu

Tolunay

Sarsmaz

et al. 2021

Gynecol Obstet Reprod Med

View full text Add to dashboard Cite

OBJECTIVES: We aimed to determine whether mean platelet volume value and/or neutrophil/lymphocyte ratio values are useful as a predictive marker for gestational cholestasis. STUDY DESIGN: Retrospective analysis of the data of patients diagnosed with pregnancy cholestasis between 2018-2019 in a perinatology clinic. 352 pregnant women were enrolled in the study (122 pregnant women with Intrahepatic cholestasis as study group and 230 pregnant women with no morbidity as the control group) RESULTS: Mean platelet volume was significantly higher in pregnant women with intrahepatic cholestasis compared to the healthy controls, 9.30 (7-18) and 8.6 (6.7-11.5), respectively. The neutrophil/lymphocyte ratio was significantly higher in pregnant women with intrahepatic cholestasis compared to the healthy controls, 3.93 (0.46-13.75) and 4.25 (0.87-17.1), respectively. There was a statistically significant difference between the two groups for mean platelet volume (p <0.001). In the roc analysis, 8.85 fL for mean platelet volume had a sensitivity of 65% and a specificity of 59%.CONCLUSION: When compared with healthy pregnancies, mean platelet volume value in gestational cholestasis increases significantly. However, the predictive strength of mean platelet volume for cholestasis is not strong enough to recommend its usage as a single parameter in clinical practice.

show abstract

The predictive value of total leukocyte count and leukocyte differential for severe preeclampsia

Cited by 8 publications

References 20 publications

Raised neutrophil lymphocyte ratio and serum beta hCG level in early second trimester of pregnancy as predictors for development and severity of preeclampsia

Raised neutrophil lymphocyte ratio and serum beta hCG level in early second trimester of pregnancy as predictors for development and severity of preeclampsia

Study of Some Hematological Markers of Systemic Inflammatory Response in Preeclampsia

Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive for Gestational Cholestasis?

Contact Info

Product

Resources

About