The predominant drug-specific T-cell population may switch from cytotoxic T cells to regulatory T cells during the course of anticonvulsant-induced hypersensitivity

Hanafusa, Takaaki; Azukizawa, Hiroaki; Matsumura, Sayaka; Katayama, Ichiro

doi:10.1016/j.jdermsci.2011.12.002

Cited by 43 publications

(33 citation statements)

References 27 publications

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“…In a study on SJS-TEN, Tregs isolated from patients with acute-stage TEN were found to be profoundly impaired in their suppressive function, which may be related to severe epidermal damage (49). Another recent study also revealed that the drug-specific Tregs proliferated during the recovery stage in 1 SCAR patient (50). Furthermore, several studies indicated that the expression levels of FOXP3 and the suppressive functions of Tregs were increased by anti-TNF-α treatment (51,52).…”

Section: Study Proceduresmentioning

confidence: 99%

Randomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions

Wang¹,

Yang²,

Chen³

et al. 2018

Journal of Clinical Investigation

213

156

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Section: Study Proceduresmentioning

confidence: 99%

Randomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions

Wang¹,

Yang²,

Chen³

et al. 2018

Journal of Clinical Investigation

213

156

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“…The drug hypersensitivity syndrome caused by abacavir is strongly associated with HLA-B*5701, and key structures in the peptide-binding cleft of HLA-B*5701 have been identified that permit non-covalent interactions with this drug [134][135][136]. This binding may also occur in so-called empty, non-peptide bearing MHC class I molecules.…”

Section: Hla and Drug Sensitivitymentioning

confidence: 99%

Clinical Role of Human Leukocyte Antigen in Health and Disease

2015

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Most of the genes in the major histocompatibility complex (MHC) region express high polymorphism that is fundamental for their function. The most important function of human leukocyte antigen (HLA) molecule is in the induction, regulation of immune responses and the selection of the T cell repertoire. A clinician's attention is normally drawn to a system only when it malfunctions. The HLA system is no exception in this regard, but in contrast to other systems, it also arouses interest when it functions well -too well, in fact. Population studies carried out over the last several decades have identified a long list of human diseases that are significantly more common among individuals that carry particular HLA alleles including inflammatory, autoimmune and malignant disorders. HLAdisease association is the name of this phenomenon, and the mechanism underlying is still a subject of hot debate. Social behaviours are affected by HLA genes and preference for HLA disparate mates may provide 'good genes' for an individual's offspring. Also, certain HLA genes may be associated with shorter life and others with longer lifespan, but the effects depend both on the genetic background and on the environmental conditions. The following is a general overview of the important functional aspects of HLA in health and diseases.

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“…Several assays to detect drug-specific T cells employing FCM are currently in use and have been described in the literature (10)(11)(12). CD69 is one of the specific markers for T-cell activation other than CD40L, and upregulation of this surface-specific marker was reportedly detected after 48 h in LTT-positive patients (8).…”

Section: Discussionmentioning

confidence: 99%

Using CD40 Ligand Expression to Detect Antigen-specific T Cells in Patients with Drug Eruptions

Higuchi¹,

Satoh²,

Yokozeki³

2014

Acta Derm Venerol

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The predominant drug-specific T-cell population may switch from cytotoxic T cells to regulatory T cells during the course of anticonvulsant-induced hypersensitivity

Cited by 43 publications

References 27 publications

Randomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions

Randomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions

Clinical Role of Human Leukocyte Antigen in Health and Disease

Using CD40 Ligand Expression to Detect Antigen-specific T Cells in Patients with Drug Eruptions

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