The preferential homing of mesenchymal stromal cells to sites of inflammation

Sullivan, Catherine

doi:10.1002/9781118907474.ch22

The Biology and Therapeutic Application of Mesenchymal Cells 2016

DOI: 10.1002/9781118907474.ch22

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The preferential homing of mesenchymal stromal cells to sites of inflammation

Catherine Sullivan

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Cited by 2 publications

References 243 publications

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Pretreating Mesenchymal Stem Cells with Cancer Conditioned‐Media or Proinflammatory Cytokines Changes the Tumor and Immune Targeting by Nanoghosts Derived from these Cells

Lupu-Haber

Bronshtein

Shalom-Luxenburg

et al. 2019

Adv Healthcare Materials

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COMMUNICATION (1 of 8)Nanoghosts (NGs) is a proprietary novel form of a targeted delivery platform, which is based on nanovesicles that are technologically reconstructed from the whole cytoplasmic membranes of human bone marrow-derived mesenchymal stem cells (MSCs). Initially developed for tumor-targeted drug Nanoghosts (NGs) are nanovesicles reconstructed from the cytoplasmic membranes of mesenchymal stem cells (MSCs). By retaining MSC membranes, the NGs retain the ability of these cells to home in on multiple tumors, laying the foundations, thereby, for the development of a targeted drug delivery platform. The susceptibility of MSCs to functional changes, following their exposure to cytokines or cancer-derived conditioned-media (CM), presents the opportunity to modify the NGs by conditioning their source cells. This opportunity is investigated by comparing the membrane protein composition and the tumor uptake of NGs derived from naïve MSCs (N-NG) against conditioned NGs made from MSCs pre-treated with conditionedmedia (CM-NG) or with a mix of the proinflammatory cytokines TNF-α and IL-1β (Cyto-NG). CM-NGs are found to be more targeted towards immune cells than Cyto-or N-NGs, while Cyto-NGs are the most tumor-targeted ones, with similar immune-targeting capacity as N-NGs but with a higher affinity towards endothelial cells. Proteomic variations were wider in the CM-NGs, with exceptionally higher levels of ICAM-1 compared to N-and Cyto-NGs. From a translational point of view, the data show that the tumor-targeting ability of the NGs, and possibly that of other MSC-derived extracellular vesicles, can be enhanced by simple conditioning of their source cells.

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Pretreating Mesenchymal Stem Cells with Cancer Conditioned‐Media or Proinflammatory Cytokines Changes the Tumor and Immune Targeting by Nanoghosts Derived from these Cells

Lupu-Haber

Bronshtein

Shalom-Luxenburg

et al. 2019

Adv Healthcare Materials

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show abstract

New insights into the application of nanoghosts as theranostic tools with an emphasis on cardiovascular diseases

et al. 2021

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The preferential homing of mesenchymal stromal cells to sites of inflammation

Cited by 2 publications

References 243 publications

Pretreating Mesenchymal Stem Cells with Cancer Conditioned‐Media or Proinflammatory Cytokines Changes the Tumor and Immune Targeting by Nanoghosts Derived from these Cells

Pretreating Mesenchymal Stem Cells with Cancer Conditioned‐Media or Proinflammatory Cytokines Changes the Tumor and Immune Targeting by Nanoghosts Derived from these Cells

New insights into the application of nanoghosts as theranostic tools with an emphasis on cardiovascular diseases

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