The prelimbic cortex regulates itch processing by controlling attentional bias

Wu, Guohao; Zheng, Xiao-Xia; Zhao, Shi-Fu; Wang, Yi; Jiang, Shan; Wang, Yisong; Yi, Yi-Lun; Yao, Juan; Han, Wen; Liu, Ju; Liu, Hongli; Sui, Jian-feng

doi:10.1016/j.isci.2022.105829

iScience

2023

DOI: 10.1016/j.isci.2022.105829

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The prelimbic cortex regulates itch processing by controlling attentional bias

Guohao Wu¹,

Xiao-Xia Zheng²,

Shi-Fu Zhao³

et al.

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Cited by 2 publications

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The Anterior Insula and its Projection to the Prelimbic Cortex are Involved in the Regulation of 5-HT-Induced Itch

Yao

et al. 2023

Neurosci. Bull.

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Itch is an unpleasant sensation that urges people and animals to scratch. Neuroimaging studies on itch have yielded extensive correlations with diverse cortical and subcortical regions, including the insular lobe. However, the role and functional specificity of the insular cortex (IC) and its subdivisions in itch mediation remains unclear. Here, we demonstrated by immunohistochemistry and fiber photometry tests, that neurons in both the anterior insular cortex (AIC) and the posterior insular cortex (PIC) are activated during acute itch processes. Pharmacogenetic experiments revealed that nonselective inhibition of global AIC neurons, or selective inhibition of the activity of glutaminergic neurons in the AIC, reduced the scratching behaviors induced by intradermal injection of 5-hydroxytryptamine (5-HT), but not those induced by compound 48/80. However, both nonselective inhibition of global PIC neurons and selective inhibition of glutaminergic neurons in the PIC failed to affect the itching-scratching behaviors induced by either 5-HT or compound 48/80. In addition, pharmacogenetic inhibition of AIC glutaminergic neurons effectively blocked itch-associated conditioned place aversion behavior, and inhibition of AIC glutaminergic neurons projecting to the prelimbic cortex significantly suppressed 5-HT-evoked scratching. These findings provide preliminary evidence that the AIC is involved, at least partially via aversive emotion mediation, in the regulation of 5-HT-, but not compound 48/80-induced itch.

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The Anterior Insula and its Projection to the Prelimbic Cortex are Involved in the Regulation of 5-HT-Induced Itch

Yao

et al. 2023

Neurosci. Bull.

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Prelimbic cortex-nucleus accumbens core projection positively regulates itch and itch-related aversion

Long,

Wang,

Xuan

et al. 2024

Behavioural Brain Research

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The prelimbic cortex regulates itch processing by controlling attentional bias

Cited by 2 publications

References 49 publications

The Anterior Insula and its Projection to the Prelimbic Cortex are Involved in the Regulation of 5-HT-Induced Itch

The Anterior Insula and its Projection to the Prelimbic Cortex are Involved in the Regulation of 5-HT-Induced Itch

Prelimbic cortex-nucleus accumbens core projection positively regulates itch and itch-related aversion

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