“…29,39 Contextual factors such as gestational age and behavioral state may play a significant role in pain assessment and are beginning to be included in some assessment tools (eg, the PIPP-Revised). 40,41 New and emerging technologies to measure pain responses, such as near-infrared spectroscopy, amplitude-integrated electroencephalography, functional MRI, skin conductance, and heart rate variability assessment, are being investigated. 53,54 These innovations hold promise in the development of neurophysiologically based methods for assessing noxious stimuli processing at the cortical level in neonates while they are awake, sedated, or anesthetized.…”