Introduction: Premature loss of deciduous teeth is considered to be one of the local environmental factors interfering with normal development of the occlusion. Extraction of deciduous tooth before the time of its physio logical exfoliation carries the risk of creation of unfavorable spatial changes in sagittal, transverse and vertical plane. Despite the undeniable role of wellpreserved primary dentition in the development of occlusion in adult hood, there are still controversies regarding indications for implementation of space maintainers. Objectives: Analysis of available literature in terms of consequences of premature loss of deciduous molar teeth. Material and methods: The literature review was conducted in PubMed, EMBASE and Scopus databases in July 2017 basing on keyword "premature primary tooth loss". English and Polishlanguage magazines were taken into account without specifying the time frame. Results: In total, 20 papers were selected for further detailed analysis, of which 11 were based on longitudinal studies, 9 were crosssectional studies (including 7 retrospective studies and 2 systematic literature reviews). Conclusions: Premature extraction of the upper first primary molar may lead to buccal eruption of permanent canine as a consequence of more mesial eruption of first premolar. Increased risk of space loss within dental arch exists especially in case of coexistence of cusp to cusp relationship on first molars and leptoprosopic facial type. Consequences of losing lower first deciduous molar are less obvious. Extraction of second deciduous molars may result in much more serious disturbances related to mesial migration of first permanent molars, resulting in re tention or abnormal eruption of second premolars. Repercussions of early loss of deciduous teeth are often visible only at the moment of eruption of permanent successors and depend on many variables, among which patient's age at the time of extraction, initial spatial conditions (crowding/spacing) and the number and type of lost teeth should be mentioned.