Quantum dots (QDs) are spherical particles with a size of <10 nm and, due to their unique properties, have good potential for use in the food industry. Among the various QDs, food industry researchers have highly regarded carbon quantum dots (CQDs) due to their nontoxicity and environmental friendliness. Food analysis is essential for quality assessment as well as safety control. In this regard, QDs-based fluorescence sensors can provide faster, more accurate, more sensitive, and cheaper analysis methods. The use of QDs to detect food additives, pathogens, heavy metals, nutrients, antibiotics, and insecticide residues is investigated in this chapter. QDs in packaging materials, due to their antioxidant, antimicrobial, and inhibitory properties, increase product shelf life, reduce the growth of microorganisms, improve mechanical properties, prevent gases and UV light, and reduce food waste. Their application in improved, active, intelligent, and bio-packaging will also be described. Then, their application in water treatment will be discussed. QDs, due to properties such as high aspect ratio, reactivity, electrostatic, hydrophilic, and hydrophobic interactions, have good potential for use in various water treatment methods, including membranes in filtration, adsorbents, and photocatalysts. Finally, their use to track protein will be investigated.