The Preparation and Properties of Composite Hydrogels Based on Gelatin and (3-Aminopropyl) Trimethoxysilane Grafted Cellulose Nanocrystals Covalently Linked with Microbial Transglutaminase

Zhao, Shouwei; Chen, Zhiwei; Dong, Yaqi; Lü, Wenhui; Zhu, Deyi

doi:10.3390/gels8030146

Cited by 10 publications

(11 citation statements)

References 37 publications

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“…By the introduction of microbial transglutaminase, the disadvantage of the high cost of enzymes has been resolved. 183 By the addition of CNCs, there will be an increase in chemical crosslinking junction points between gelatin and nanocrystals. Microbial transglutaminase from streptomycetes (mTG) used in the food industry to enhance the functional properties of protein rich food can make covalent bond cross-linking within and between gelatin by catalyzing the transfer of amide bonds.…”

Section: Materials and Their Clinical Applicationsmentioning

confidence: 99%

“…This created a covalent bond between nanocellulose and gelatin with the aid of mTG and ensured a uniform dispersion of nanocellulose in the gelatin matrix. 183 Nanocellulose has been in demand for drug delivery carriers due to its unique features. This drug delivery could be enhanced in a controlled fashion when incorporated into a biocompatible polymer like gelatin.…”

Section: Materials and Their Clinical Applicationsmentioning

confidence: 99%

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Nanocellulose-Based Hybrid Scaffolds for Skin and Bone Tissue Engineering: A 10-Year Overview

Sreedharan,

Vijayamma,

Liyaskina

et al. 2024

Biomacromolecules

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Cellulose, the most abundant polymer on Earth, has been widely utilized in its nanoform due to its excellent properties, finding applications across various scientific fields. As the demand for nanocellulose continues to rise and its ease of use becomes apparent, there has been a significant increase in research publications centered on this biomaterial. Nanocellulose, in its different forms, has shown tremendous promise as a tissue engineered scaffold for regeneration and repair. Particularly, nanocellulose-based composites and scaffolds have emerged as highly demanding materials for both soft and hard tissue engineering. Medical practitioners have traditionally relied on collagen and its analogue, gelatin, for treating tissue damage. However, the limited mechanical strength of these biopolymers restricts their direct use in various applications. This issue can be overcome by making hybrids of these biopolymers with nanocellulose. This review presents a comprehensive analysis of the recent and most relevant publications focusing on hybrid composites of collagen and gelatin with a specific emphasis on their combination with nanocellulose. While bone and skin tissue engineering represents two areas where a majority of researchers are concentrating their efforts, this review highlights the use of nanocellulose-based hybrids in these contexts.

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Section: Materials and Their Clinical Applicationsmentioning

confidence: 99%

Section: Materials and Their Clinical Applicationsmentioning

confidence: 99%

Nanocellulose-Based Hybrid Scaffolds for Skin and Bone Tissue Engineering: A 10-Year Overview

Sreedharan,

Vijayamma,

Liyaskina

et al. 2024

Biomacromolecules

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“…Biosourced rod-like colloids (RC) and rod-like polymers (RP) have excellent mechanical and optical properties and are often regarded as sustainable and biocompatible building blocks. − These features have been exploited to form novel materials − with applications in biomedical − and food engineering. − Classical examples of biosourced RC that can be produced in industrially relevant quantities comprise cellulose nanofibrils, cellulose nanocrystals, and protein nanofibrils. Nonetheless, these RC are characterized by a polydisperse contour length which complicates the prediction of their flow behavior.…”

Section: Introductionmentioning

confidence: 99%

Alignment–Rheology Relationship of Biosourced Rod-Like Colloids and Polymers under Flow

et al. 2023

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Fluids composed of biosourced rod-like colloids (RC) and rod-like polymers (RP) have been extensively studied due to various promising applications relying on their flow-induced orientation (e.g., fiber spinning). However, the relationship between RC and RP alignment and the resulting rheological properties is unclear due to experimental challenges. We investigate the alignment−rheology relationship for a variety of biosourced RC and RP, including cellulose-based particles, filamentous viruses, and xanthan gum, by simultaneous measurements of the shear viscosity and fluid anisotropy under rheometric shear flows. For each system, the RC and RP contribution to the fluid viscosity, captured by the specific viscosity η sp , follows a universal trend with the extent of the RC and RP alignment independent of concentration. We further exploit this unique rheological-structural link to retrieve a dimensionless parameter (β) directly proportional to η sp at zero shear rate (η 0,sp ), a parameter often difficult to access from experimental rheometry for RC and RP with relatively long contour lengths. Our results highlight the unique link between the flow-induced structural and rheological changes occurring in RC and RP fluids. We envision that our findings will be relevant in building and testing microstructural constitutive models to predict the flowinduced structural and rheological evolution of fluids containing RC and RP.

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“…On the other hand, hydrogels can also be divided into synthetic polymer hydrogels and natural polymer hydrogels according to the different synthetic raw materials [ 31 ]. The natural polymer has attracted more attention due to its biocompatibility, abundant source, low price and good biomedical application prospects.…”

Section: Introductionmentioning

confidence: 99%

Advances in Cellulose-Based Hydrogels for Biomedical Engineering: A Review Summary

Zou¹,

Yao²,

Cui³

et al. 2022

Gels

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In recent years, hydrogel-based research in biomedical engineering has attracted more attention. Cellulose-based hydrogels have become a research hotspot in the field of functional materials because of their outstanding characteristics such as excellent flexibility, stimulus-response, biocompatibility, and degradability. In addition, cellulose-based hydrogel materials exhibit excellent mechanical properties and designable functions through different preparation methods and structure designs, demonstrating huge development potential. In this review, we have systematically summarized sources and types of cellulose and the formation mechanism of the hydrogel. We have reviewed and discussed the recent progress in the development of cellulose-based hydrogels and introduced their applications such as ionic conduction, thermal insulation, and drug delivery. Also, we analyzed and highlighted the trends and opportunities for the further development of cellulose-based hydrogels as emerging materials in the future.

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The Preparation and Properties of Composite Hydrogels Based on Gelatin and (3-Aminopropyl) Trimethoxysilane Grafted Cellulose Nanocrystals Covalently Linked with Microbial Transglutaminase

Cited by 10 publications

References 37 publications

Nanocellulose-Based Hybrid Scaffolds for Skin and Bone Tissue Engineering: A 10-Year Overview

Nanocellulose-Based Hybrid Scaffolds for Skin and Bone Tissue Engineering: A 10-Year Overview

Alignment–Rheology Relationship of Biosourced Rod-Like Colloids and Polymers under Flow

Advances in Cellulose-Based Hydrogels for Biomedical Engineering: A Review Summary

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