The preparation and the in-vitro pharmacodynamics study of the intracapsular sustained-release preparations for the prevention of posterior capsule opacification

Dong, Qian; Yi, Shaoling; Peng, Zhimin; Zhao, Chunshun

doi:10.1016/j.ajps.2013.08.001

Cited by 8 publications

(4 citation statements)

References 41 publications

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“…The characteristic absorption band of DTX (blue) is the stretching vibration of N-H at 3476 and 3425 cm À1 and outplane vibration of this band was observed at 715 cm À1 [54]. The vibrational bands of nanoMIL-100(Fe) around 1705, 1624, 1447 and 1378 cm À1 were all observed in the FTIR spectrum of the DTX-loaded nanoMIL-100(Fe), which confirmed the stability of the nanoMIL-100(Fe) after loading process without any chemical reaction with DTX molecule.…”

Section: Characterization Of Dtx-loaded Nanomil-100mentioning

confidence: 99%

NanoMIL-100(Fe) containing docetaxel for breast cancer therapy

Rezaei

Abbasi

Varshochian

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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Metal-organic frameworks, such as MIL-100, have been recently introduced as promising drug carriers due to their notable characteristics such as stability, biocompatibility and owning large porosity which may admit a broad range of drugs with different molecular sizes. In this study, we firstly proposed an accessible top-down approach using ultrasound method to prepare nanoMIL-100 and secondly, evaluated its potentials as an anticancer nanocarrier. This is the first report that docetaxel (DTX) as a highly hydrophobic anticancer drug was encapsulated in nanoMIL-100 with the drug payload of 57.2 wt%. Characterizations of the prepared nanoMIL-100 and DTX-loaded nanoMIL-100 were performed by PXRD, FT-IR, N adsorption, DLS and FE-SEM. Moreover, the drug loading and release processes were quantified by HPLC. The in vitro release of DTX from the prepared nanocarrier was investigated in two pH values, 7.4 and 5.5. The toxic effect of DTX-loaded nanoMIL-100 was examined on human breast cancer cell line, MCF-7, and a significant decrease was observed in IC value (0.198 μg/mL) at the first 24 h in comparison with the free drug (4.9908 μg/mL). This nanocarrier may, thus offer promising potentials as a novel cytotoxic drug delivery system.

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Section: Characterization Of Dtx-loaded Nanomil-100mentioning

confidence: 99%

NanoMIL-100(Fe) containing docetaxel for breast cancer therapy

Rezaei

Abbasi

Varshochian

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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“…Moreover, the appearance of new peaks at 709 and 1261 cm −1 , which respectively belong to out-of-plane N−H vibration and C−N stretching vibration of DTX, confirms loading of DTX on GO. 63,64 The close proximity of drug molecules and GO sheets was verified by comparing the fluorescence spectra of GO−DTX with the same concentration of DTX at excitation wavelength 300 nm. Figure 3c shows that although DTX displays weak fluorescence at emission wavelength of 370 nm, this fluorescence intensity is quenched after drug loading, due to the close binding between DTX and GO.…”

Section: ■ Results and Discussionmentioning

confidence: 84%

“…As shown in Figure b, the peaks of GO at 1623 and 1097 cm –1 shift to higher positions at 1635 and 1116 cm –1 in GO–DTX, which can be explained by the formation of hydrogen bonds and π–π stacking between DTX and GO. Moreover, the appearance of new peaks at 709 and 1261 cm –1 , which respectively belong to out-of-plane N–H vibration and C–N stretching vibration of DTX, confirms loading of DTX on GO. , …”

Section: Results and Discussionmentioning

confidence: 99%

Targeted Delivery of Docetaxel by Use of Transferrin/Poly(allylamine hydrochloride)-functionalized Graphene Oxide Nanocarrier

Nasrollahi

Varshosaz²,

Khodadadi

et al. 2016

ACS Appl. Mater. Interfaces

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The exceptional chemical and physical properties of graphene oxide (GO) make it an attractive nanomaterial for biomedical applications, particularly in drug delivery. In this work we synthesized a novel, GO-based nanocarrier for the delivery of docetaxel (DTX), a potent hydrophobic chemotherapy drug. The GO was functionalized with transferrin (Tf)-poly(allylamine hydrochloride) (PAH), which provided targeted and specific accumulation to extracellular Tf receptors and stabilized GO in physiological solutions. Tf was conjugated to PAH via amide covalent linkages, and Tf-PAH coated the surface of DTX-loaded GO through electrostatic interactions. The morphology and structure of the resulting nanostructure, along with its surface modifications, were verified by use of Fourier transform infrared (FT-IR) and UV-vis spectroscopy, atomic force microscopy (AFM), and scanning electron microscopy (SEM). DTX was loaded at a relatively high loading capacity of 37% and released in a pH-dependent and sustained manner under physiological conditions. The targeting efficiency and cytotoxicity of this drug delivery system were evaluated on MCF-7 breast cancer cells. Improved efficacy of targeted DTX-loaded nanocarrier was observed compared to nontargeted carrier and free DTX, especially at high drug concentrations. The Tf-PAH-functionalized GO nanocarrier is a promising candidate for targeted delivery and controlled release of DTX.

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“…Nowadays, the most frequently used preparative methods for sustained-release pellets formation include rolling method, centrifugalization-fluidization method, spraying-congelation method, spray drying and liquid medium method, and so on. However, extrusionspheronization method is the most best one with the advantage of convenient operation, having the rounded, smooth and complete resulting samples of comparable size and proper rigidity (Su et al, 2012;Wang et al, 2010;Dong et al, 2013). For the postmarketing drug sample in USA, which used as control in this study, it was prepared by coating impermeable liner after fluidization dressing into the blank pellets with agent.…”

Section: Discussionmentioning

confidence: 99%

Preparation and evaluation of novel galantamine hydrobromide sustained-release capsule

Yang

2016

Bangladesh J Pharmacol

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In present study, a novel galantamine hydrobromide sustained-release capsule was prepared with the extrusion-spheronization method and the optimized preparative formulation. The release studies were performed using marketed capsules (Razadyne ER) as a reference and data were analyzed in terms of cumulative release amounts as a function of time. Furthermore, fiber-optic real time detection was adopted to monitor the release process. Results demonstrated that our developed formulation had superior properties, worked better as sustained-release carriers and lasted longer time to release compared with the marketed product. The in vitro release characteristics of different batches of preparations were quite similar with each other, the total release proportions of galantamine hydrobromide from sustained-release capsules reached higher than 90% within 12 hours. Similar factors f2 of two preparations were all higher than 50, the release profile of drugs from capsules fitted to Higuchi model with the equation of Q% = 0.2681t1/2 + 0.0684 (r = 0.9966). Pharmacokinetics profile and parameters in beagle dogs after oral administration also revealed the superior release performances of new capsules being consistent with the in vitro study. The developed sustained-release formulation may be a promising alternative dosage form for treatment of related diseases.

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The preparation and the in-vitro pharmacodynamics study of the intracapsular sustained-release preparations for the prevention of posterior capsule opacification

Cited by 8 publications

References 41 publications

NanoMIL-100(Fe) containing docetaxel for breast cancer therapy

NanoMIL-100(Fe) containing docetaxel for breast cancer therapy

Targeted Delivery of Docetaxel by Use of Transferrin/Poly(allylamine hydrochloride)-functionalized Graphene Oxide Nanocarrier

Preparation and evaluation of novel galantamine hydrobromide sustained-release capsule

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