The preparation and validation of chitosan tablets that rapidly disperse and disintegrate as an oral adsorbent in the treatment of lifestyle-related diseases

Development of Dispersible Vaginal Tablets of Tenofovir Loaded Mucoadhesive Chitosan Microparticles for Anti-HIV Pre-Exposure Prophylaxis

“…This reflects good TCM distribution and homogeneity in the matrix of the dispersible tablet. , The dimensional stability of F1–F3 tablets was maintained for a few seconds after dropping it in SVF, following which complete disintegration was observed within approximately 30–40 s of time with no mass remaining in the apparatus. The tablets from batch F4 were found to disintegrate in approximately 60 s. The rapid disintegration of F3 tablet within 31.34 ± 4.63 s, indicates faster penetration of water into the interparticle space and good hydrophilicity of chitosan, thereby reflecting the superdisintegrant ability of chitosan polymer. , From the results of the physical characterization of the tablets, it was concluded that tablet F3 should be considered for further in vitro dissolution studies.…”

“…By virtue of the polymer properties, the mechanism of drug release from the tablets containing bioadhesive microparticles was found to be swelling and diffusion controlled, thereby indicating that the formulation was in accordance with the zero-order kinetics ( R 2 = 0.95 ± 0.02) and Higuchi model ( R 2 = 0.98 ± 0.01). From the Korsmeyer–Peppas model, the diffusion coefficient value was found to be n = 0.414 ± 0.081 < 0.50, indicating drug diffusion out of the matrix tablet via pure Fickian diffusion. ,, Therefore, the formulated vaginal tablet inherently exhibited a sustained drug release. From the commercial perspective, tablets can be considered as vaginal inserts for antiretroviral drug delivery, as it is one of the major source regions for HIV transmission.…”

“…The tablets from batch F4 were found to disintegrate in approximately 60 s. The rapid disintegration of F3 tablet within 31.34 ± 4.63 s, indicates faster penetration of water into the interparticle space and good hydrophilicity of chitosan, thereby reflecting the superdisintegrant ability of chitosan polymer. 32,81 From the results of the physical characterization of the tablets, it was concluded that tablet F3 should be considered for further in vitro dissolution studies.…”

“…From the Korsmeyer−Peppas model, the diffusion coefficient value was found to be n = 0.414 ± 0.081 < 0.50, indicating drug diffusion out of the matrix tablet via pure Fickian diffusion. 33,50,81 Therefore, the formulated vaginal tablet inherently exhibited a sustained drug release. From the commercial perspective, tablets can be considered as vaginal inserts for antiretroviral drug delivery, as it is one of the major source regions for HIV transmission.…”