1944
DOI: 10.1021/ja01230a031
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The Preparation of N-Mono-substituted and Unsymmetrically Disubstituted Piperazines

Abstract: The Preparation of Some Substituted Piperazines 263 tained pure because both were very hygroscopic. The picrate and picrolonate were obtained as well-characterized crystalline salts.Picrate.-Prepared in and recrystallized from absolute ethanol, the picrate formed yellow elongated prisms which softened at 210°and melted, with decomposition, at 218.5-219.5°(cor.).

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Cited by 44 publications
(19 citation statements)
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“…Although DBZP is a byproduct in the synthesis of BZP [12] , there is scarce data on its biological activity [8,15] ; however, DBZP has been detected as a contaminant in the analysis of BZP [16][17][18] . The amount of DBZP present in BZP samples depends of the synthesis procedure [18] .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Although DBZP is a byproduct in the synthesis of BZP [12] , there is scarce data on its biological activity [8,15] ; however, DBZP has been detected as a contaminant in the analysis of BZP [16][17][18] . The amount of DBZP present in BZP samples depends of the synthesis procedure [18] .…”
Section: Discussionmentioning
confidence: 99%
“…BZP and DBZP were synthesized at the Pharmacy Department, Chemistry School UNAM following standard procedure [12] . N -BEDA, BA, scopolamine hydrochloride, and piracetam were acquired from Sigma Co. (St. Louis, MO, USA).…”
Section: Drugs and Dosagementioning
confidence: 99%
“…6 Hence, we synthesised N-benzoylpiperazine 3 by the literature method. 7 This was reacted with compound 2 which had been synthesised via a Blanc chloromethylation reaction to furnish unsymmetrically disubstituted piperazine 4 in good yield (89% based on 2).…”
Section: Resultsmentioning
confidence: 99%
“…It was originally synthesized by researchers from Burroughs, Wellcome & Co. (Baltzly et al 1944). It is widely stated that the chemical was synthesized for experimentation as a de-worming agent for cattle but research was abandoned in favour of more promising piperazine compounds (for example see McNamara [2009]; originally stated in Campbell et al [1973]).…”
Section: Development Of Bzpmentioning
confidence: 99%
“…Following the Baltzly et al (1944) synthesis,there was little further investigation of BZP in the literature until human studies were performed in the early 1970s, exploring the drug's suitability as an anti-depressant (see 'Early research on BZP' below). A speculative patent for BZP-derived antidepressants was filed by Wellcome researchers in the 1960s (Barrett et al 1968), and stated that BZP was effective in reversing various pharmacological animal models of depression.…”
Section: Development Of Bzpmentioning
confidence: 99%