The Preparation of Raffinose From Cottonseed Meal

Adsorption separation of raffinose from sucrose by activated carbon: Equilibrium, kinetics and dynamic breakthrough

“…As a high value-added oligosaccharide, preparation of raffinose has gained both academic and commercial interests (9)(10)(11)(12)(13)(14). Despite catalytic synthesis of raffinose has been extensively investigated (15)(16)(17)(18)(19); however, this method still suffers a disadvantage of inadequate yield and as well generates useless by-products during the synthesis.…”

“…Despite catalytic synthesis of raffinose has been extensively investigated (15)(16)(17)(18)(19); however, this method still suffers a disadvantage of inadequate yield and as well generates useless by-products during the synthesis. Excluding sucrose, raffinose is probably the most widespread oligosaccharide in the plant world, especially abundant in the sugar beet and cotton seed (20), thus producing raffinose by extraction from biomass-based wastes like the sugar beet molasses (12,21,22) and cottonseed meal (9)(10)(11)(23)(24)(25) might be a more environmentally friendly and low-cost process. In reality, the preparation of raffinose has been realized on a large scale by extraction from sugar beets as a by-product of sugar processing in Japan.…”

“…Highly pure raffinose can be obtained from sugar beet molasses containing sucrose and betaine by chromatographic separation based on ion-exchange resin followed by crystallization (14,21,22). Besides, it has also been reported that cottonseed meal may be a more important and lower cost resource for raffinose production (9)(10)(11)(23)(24)(25). In our previous studies, we worked on the separation of raffinose that was extracted from cottonseed meal using aqueous ethanol of 70% as the solvent, and found that the presence of sucrose in the concentrated extract deteriorates the crystallization recovery of raffinose very significantly.…”

One‐Pot Conversions of Raffinose into Furfural Derivatives and Sugar Alcohols by Using Heterogeneous Catalysts

“…The use of biorenewable resources allows the exploration of opportunities that will partly contribute to secure the domestic supply of energy, support agricultural economics, and produce energy from renewable resources in a carbon-neutral way. [7][8][9][10] Recently, raffinose has gained interest as a potential excipient in stabilizing biomolecules because its specific stabilizing properties are reported to be superior to other sugars, such as lactose, maltose, and sucrose. [5] Raffinose (O-a-d-galactopyranosyl-(1!6)-O-a-d-glucopyranosyl-(1$2)-O-b-d-fructofuranoside) is a naturally occurring indigestible trisaccharide [6] that is composed of galactose, glucose, and fructose sugar units (see Scheme 1) and is one of the most abundant oligosaccharides found in plants and agricultural products, such as beet molasses, sugar cane, honey, eucalyptus manna, cottonseed meal, leaves of the yew, potatoes, grapes, and the seeds of many leguminous plants.…”

“…[5] Raffinose (O-a-d-galactopyranosyl-(1!6)-O-a-d-glucopyranosyl-(1$2)-O-b-d-fructofuranoside) is a naturally occurring indigestible trisaccharide [6] that is composed of galactose, glucose, and fructose sugar units (see Scheme 1) and is one of the most abundant oligosaccharides found in plants and agricultural products, such as beet molasses, sugar cane, honey, eucalyptus manna, cottonseed meal, leaves of the yew, potatoes, grapes, and the seeds of many leguminous plants. [7][8][9][10] Recently, raffinose has gained interest as a potential excipient in stabilizing biomolecules because its specific stabilizing properties are reported to be superior to other sugars, such as lactose, maltose, and sucrose. [11] Raffinose can be completely converted into three hexoses, namely, galactose, glucose, and fructose, through hydrolysis, which are economical and suitable for use as chemical feedstocks (Scheme 1).…”