The Presence of Biofilms in Instrumented Spinal Fusions

Dupré, Derrick A.; Cheng, Boyle C.; Melton-Kreft, Rachael; Nistico, Laura; Ehrlich, Garth D.; Averick, Saadyah; Altman, Daniel T.

doi:10.1089/gtmb.2022.0026

Cited by 3 publications

(2 citation statements)

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“…Traditional treatment protocols for spinal SSI involve early recognition, debridement, irrigation, and administration of organism-specific antibiotics [9][10][11][12]. One of the main causes of treatment failure in spinal infections is biofilm formation [13]. These biofilms, which can form on vertebrae, other spinal structures, or implants, contribute to the chronicity and treatment resistance of spinal infections [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Toothbrushing Technique for Biofilm Removal and Postoperative Infection Control after Spinal Fusion Surgery: A Retrospective Study

Choi,

Kwon,

Suk

et al. 2023

Bioengineering

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This retrospective study was designed to investigate the effectiveness of using a toothbrush, which is commonly used in our daily life, for biofilm removal and infection control in the treatment of spinal infections occurring after spinal fusion surgery. Currently, a biofilm is thought to form on the surface of the metal inserted during spine fusion surgery. We aim to determine the differences in clinical outcomes between using and not using a toothbrush to remove biofilm while performing conventional drainage, curettage, and debridement. A total of 1081 patients who underwent anterior or posterior spinal fusion surgery between November 2018 and October 2022 were screened. The study included 60 patients who developed surgical site infection and underwent incision and drainage surgery either with a toothbrush (n = 20) or without a toothbrush (n = 40). Failure of infection control that requires revision surgery occurred in 2 patients (10%) in the Toothbrush group and in 14 patients (35%) in the No-Toothbrush group (p = 0.039). Thus, the rate of additional surgery was significantly lower in the Toothbrush group. Additionally, normalization of c-reactive protein levels occurred significantly faster in the Toothbrush group (p = 0.044). Therefore, using a toothbrush to treat spinal infections following spinal fusion surgery appears to have beneficial mechanical debridement effects, resulting in improved clinical results, which were also confirmed based on the electron microscopic images.

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Section: Introductionmentioning

confidence: 99%

“…These biofilms, which can form on vertebrae, other spinal structures, or implants, contribute to the chronicity and treatment resistance of spinal infections [14][15][16]. Additionally, biofilm can cause pseudoarthrosis and persistent back pain, even if the wound is sterile [13].…”

Section: Introductionmentioning

confidence: 99%