The Presence of Human Papillomavirus and Epstein-Barr Virus Infection in Gastric Cancer: A Systematic Study

Jafari-Sales, Abolfazl; Shariat, Afsoon; Baghi, Hossein Bannazadeh; Baradaran, Behzad; Jafari, Behboud

doi:10.32604/oncologie.2022.024161

Cited by 7 publications

(5 citation statements)

References 97 publications

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“…These properties suggest that sevoflurane may have enhanced oxidation resistance and a protective effect on brain tissue[ 20 ]. This feature reduces the required anesthetic dosage, eliminates the potential impact of drug solutions on body tissues, and ensures a more stable anesthetic effect[ 21 - 23 ]. A study suggested that sevoflurane possesses stable physicochemical properties and can provide cerebral protection by guarding against neuroelectrophysiological alterations in the hippocampus[ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…This feature reduces the required anesthetic dosage, eliminates the potential impact of drug solutions on body tissues, and ensures a more stable anesthetic effect[ 21 - 23 ]. A study suggested that sevoflurane possesses stable physicochemical properties and can provide cerebral protection by guarding against neuroelectrophysiological alterations in the hippocampus[ 21 ]. Previous research has primarily concentrated on investigating the application of propofol as well as sevoflurane in elderly patients undergoing radical gastric cancer resection, neglecting an analysis of their application effects in gastric cancer patients of various ages[ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

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Impact of propofol and sevoflurane anesthesia on cognition and emotion in gastric cancer patients undergoing radical resection

Li,

Bu,

Wang

et al. 2024

World J Gastrointest Oncol

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BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric cancer. However, there is a debate concerning their differential effects on cognitive function, anxiety, and depression in patients undergoing this procedure. AIM To compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function, anxiety, depression, and organ function in patients undergoing radical resection of gastric cancer. METHODS A total of 80 patients were involved in this research. The subjects were divided into two groups: Propofol group and sevoflurane group. The evaluation scale for cognitive function was the Loewenstein occupational therapy cognitive assessment (LOTCA), and anxiety and depression were assessed with the aid of the self-rating anxiety scale (SAS) and self-rating depression scale (SDS). Hemodynamic indicators, oxidative stress levels, and pulmonary function were also measured. RESULTS The LOTCA score at 1 d after surgery was significantly lower in the propofol group than in the sevoflurane group. Additionally, the SAS and SDS scores of the sevoflurane group were significantly lower than those of the propofol group. The sevoflurane group showed greater stability in heart rate as well as the mean arterial pressure compared to the propofol group. Moreover, the sevoflurane group displayed better pulmonary function and less lung injury than the propofol group. CONCLUSION Both propofol and sevoflurane could be utilized as maintenance anesthesia during radical resection of gastric cancer. Propofol anesthesia has a minimal effect on patients' pulmonary function, consequently enhancing their postoperative recovery. Sevoflurane anesthesia causes less impairment on patients' cognitive function and mitigates negative emotions, leading to an improved postoperative mental state. Therefore, the selection of anesthetic agents should be based on the individual patient's specific circumstances.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact of propofol and sevoflurane anesthesia on cognition and emotion in gastric cancer patients undergoing radical resection

Li,

Bu,

Wang

et al. 2024

World J Gastrointest Oncol

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“…Similarly, China had a huge number of STAD patients ( Abbas et al, 2018 ; Yang et al, 2021 ). Poor lifestyle habits such as high oil and salt, virus infection or smoking and alcohol abuse in some regions were the leading causative factors of STAD ( Jafari-Sales et al, 2022 ; Yang et al, 2021 ). With limited cancer symptoms and unpopular awareness of early screening, many STAD patients progress to advanced stages before being detected ( Hoft, Noto & DiPaolo, 2021 ; Li et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Single-cell data revealed CD14-type and FCGR3A-type macrophages and relevant prognostic factors for predicting immunotherapy and prognosis in stomach adenocarcinoma

Li,

Lu,

et al. 2024

PeerJ

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Background Stomach adenocarcinoma (STAD) exhibits profound tumor heterogeneity and represents a great therapeutic challenge. Single-cell sequencing technology is a powerful tool to identify characteristic cell types. Methods Single-cell sequencing data (scRNA-seq) GSE167297 and bulk RNA-seq data from TCGA, GTEx, GSE26901 and GSE15459 database were included in this study. By downscaling and annotating the cellular data in scRNA-seq, critical cell types in tumor progression were identified by AUCell score. Relevant gene modules were then identified by weighted gene co-expression network analysis (WGCNA). A prognostic scoring system was constructed by identifying prognostic factors in STAD by Least absolute shrinkage and selection operator (LASSO) COX model. The prognosis and model performance in the RiskScore groups were measured by Kaplan-Meier (K-M) curves and Receiver operating characteristic (ROC) curves. Nomogram was drawn based on RiskScore and prognosis-related clinical factors. In addition, we evaluated patient’s feedback on immunotherapy in the RiskScore groups by TIMER, ESTIMATE and TIDE analysis. Finally, the expression levels of prognostic factors were verified in gastric cancer cell lines (MKN7 and MKN28) and human normal gastric mucosal epithelial cells (GES-1), and the effects of prognostic factors on the viability of gastric cancer cells were examined by the CCK8 assay and cell cycle. Results scRNA-seq analysis revealed that 11 cell types were identified, and macrophages exhibited relatively higher AUCell scores and specifically expressed CD14 and FCGR3A. High macrophage scores worsened the prognosis of STAD patients. We intersected the specifically expressed genes in macrophages subgroups (670) and macrophage module genes (2,360) obtained from WGCNA analysis. Among 86 common genes, seven prognostic factors (RGS2, GNAI2, ANXA5, MARCKS, CD36, NRP1 and PDE4A) were identified and composed a RiskScore model. Patients in low Risk group showed a better survival advantage. Nomogram also provided a favorable prediction for survival at 1, 3 and 5 years in STAD patients. Besides, we found positive feedback to immunotherapy in patients with low RiskScore. The expression tendency of the seven prognostic factors in MKN7 and MKN28 was consistent with that in the RNA-seq data in addition to comparison of protein expression levels in the public HPA (The Human Protein Atlas) database. Further functional exploration disclosed that MARCKS was an important prognostic factor in regulating cell viability in STAD. Conclusion This study preliminary uncovered a single cell atlas for STAD patients, and Macrophages relevant gene signature and nomogram displayed favorable immunotherapy and prognostic prediction ability. Collectively, our work provides a new insight into the molecular mechanisms and therapeutic approach for LUAD patients.

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“…Therefore, identifying the factors involved in the occurrence of cancer can be useful for the health system. Human papillomavirus (HPV) is a well-known sexually transmitted virus (22)(23)(24)(25) that is primarily associated with cervical cancer, followed by anal, penile, and head and neck cancer. However, new evidence suggests a potential link between HPV infection and BC (26)(27)(28)(29)(30).…”

Section: Introductionmentioning

confidence: 99%

Human Papilloma Virus Infection in Iranian Women with Breast Cancer: A Systematic Review

Jafari Sales,

Ebrahimzadeh,

Pashazadeh

2024

J Clin Res Paramed Sci

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Background: Breast cancer (BC) is one of the most common cancers and health problems in women under the age of 40. Objectives: This systematic study investigates the presence of human papilloma virus (HPV) in Iranian women with BC by searching various international and Iranian databases using standardized keywords. Methods: The inclusion and exclusion criteria were applied to select 22 articles with a total of 2445 BC samples for data extraction and analysis using Statistical Package for the Social Sciences (SPSS) software. Results: The results show that 21.10% of BC samples were HPV positive with Khuzestan, Shahrekord, Mashhad, and Karaj having the highest number of HPV-positive cases among women with BC. Polymerase chain reaction (PCR) was the most used method for detecting HPV in the studies. The distribution of BC samples was highest in Karaj, Tehran, and Golestan. Conclusions: This study provides valuable information about the prevalence of HPV in Iranian women with BC and the geographical distribution of positive cases.

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The Presence of Human Papillomavirus and Epstein-Barr Virus Infection in Gastric Cancer: A Systematic Study

Cited by 7 publications

References 97 publications

Impact of propofol and sevoflurane anesthesia on cognition and emotion in gastric cancer patients undergoing radical resection

Impact of propofol and sevoflurane anesthesia on cognition and emotion in gastric cancer patients undergoing radical resection

Single-cell data revealed CD14-type and FCGR3A-type macrophages and relevant prognostic factors for predicting immunotherapy and prognosis in stomach adenocarcinoma

Human Papilloma Virus Infection in Iranian Women with Breast Cancer: A Systematic Review

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