The presence of human papillomavirus type 16/18 DNA in blood circulation may act as a risk marker of lung cancer in Taiwan

Chiou, Hui‐Ling; Wu, Ming-Fang; Liaw, Y. P.; Cheng, Ya‐Wen; Wong, Ruey-Hong; Chen, Chin-Yi; Lee, Huei

doi:10.1002/cncr.11191

Cited by 72 publications

(74 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent studies in Taiwan detected identical sequences of L1 and E6 of HPV16/18 in LCs and blood cells. In addition, female lung cancer patients showed a correlation between HPV16/18 detection frequencies in LCs and cervical smears (Chiou et al, 2003). Those findings suggest that HPV detected in LC may originate in the uterine cervix and spread to lung tissue via the bloodstream.…”

Section: Discussionmentioning

confidence: 76%

Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile

et al. 2007

View full text Add to dashboard Cite

The human papillomavirus (HPV) was detected in 20 (29%) out of 69 lung carcinomas (LCs) in Chile, by PCR and Southern blot, and was more frequently detected in squamous cell carcinoma (SQC) than in adenocarcinomas (46 vs 9%, P ¼ 0.001). HPV-16, positive in 11 cases, was the most frequently detected HPV genotype determined by DNA sequencing. HPV-16 E2/E6 ratio, estimated from real-time PCR analysis, was much lower than the unity, suggesting that at least a partial HPV-16 genome was integrated in all but one HPV-16-positive SQCs. The remaining one case was suspected to have only episomal HPV-16. Although the viral load was low in most of the LCs, a case showed the HPV-16 copy number as high as 8479 per nanogram DNA, which was even a few times higher than the minimum viral load of seven cervical carcinomas (observed viral load: 3356 -609 392 per nanogram DNA). The expression of the HPV-16/18 E6 protein was found in only two HPV-16-positive SQCs (13%) but not in the case with the highest viral load. Although the viral load was in general very low and HPV E6 expression is none or weak, further studies seem warranted to examine aetiological involvement of high-risk HPV in lung carcinogenesis.

show abstract

Section: Discussionmentioning

confidence: 76%

Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile

et al. 2007

View full text Add to dashboard Cite

show abstract

“…HPV has long been thought not to have a viraemic phase in humans, although more recent data suggests that it my not be so (12,13). In lung cancer, Chiou et al raised the possibility of viraemic spread when they described a 70% concordance rate between HPV DNA in peripheral blood and paired lung cancer tissue (14). Even if viraemic spread were possible the low prevalence of HPV in the general population would imply a low rate of HPV infection in lung if any.…”

Section: Discussionmentioning

confidence: 99%

Assessment of human papillomavirus and Epstein-Barr virus in lung adenocarcinoma

Lim

2009

Oncol Rep

View full text Add to dashboard Cite

Abstract. The association of human papillomavirus (HPV) and Epstein-Barr virus (EBV) infection with non-small cell lung cancer is controversial. HPV and EBV prevalence in a uniform population of lung adenocarcinoma was investigated, hypothesizing that there would be differences seen between smokers and non-smokers and between sexes. Patients involved in this study were selected from a single institution database of lung cancer. In total 497 patients with adenocarcinoma were identified and 110 patients had sufficient tissue for analysis with an in situ hybridization method that probed for high-risk and low-risk HPV and EBV. There were 65 males and 45 females, 78 patients with stage I-IIIA disease and 32 patients with stage IIIB-IV disease. There were similar number of smokers and non-smokers. Across all stages HPV and EBV staining was absent from all tissues examined. It is unlikely that HPV or EBV is an important etiological agent in adenocarcinoma of the lung, even among the neversmokers. IntroductionCigarette smoke is strongly associated with the development of lung cancer (1). While the epidemic of smoking has reduced through public health awareness programs and education, the incidence of lung cancer remains unabated. There has been a demographic change in the global pandemic with a global realignment of histological subtypes. Adenocarcinoma incidence is rising globally among both smokers and nonsmokers. Up to 30% of all diagnosed non-small cell lung cancer (NSCLC) among various Asian countries, including Singapore, do not have a history of exposure to cigarette smoking. These patients tend to be predominantly female and have adenocarcinoma (2). This has given rise to different postulates as to the possible etiologies of NSCLC in this distinct of patients, ranging from exposure to cooking oil fumes (3,4), as well as diet and cancer susceptibility genotypes among Asians (5-7). Human papillomavirus (HPV) and Epstein-Barr virus (EBV) have been variously described to be associated and causative with several cancers. HPV is likely to be causal in cervical carcinoma and head and neck squamous cell carcinoma (HNSCC), and EBV in nasopharyngeal carcinoma. There have been various reports of association between HPV and EBV with lung cancer but results have not been conclusive (8). Leveraging on the excess of non-tobacco related lung cancer in our patients we investigated HPV and EBV prevalence in a uniform population of adenocarcinoma of the lung, hypothesizing that there would be differences seen between smokers and nonsmokers and between sexes. Patients and methodsPatients. Patients involved in this study were selected from a database of NSCLC patients, diagnosed in a single institution (SGH) from 1999 to 2002. The study had the approval of the Institutional Review Board of National Cancer Centre Singapore. The main selection criterion was a diagnosis of adenocarcinoma. Four hundred and ninety-seven patients were identified and among them, 110 patients had sufficient tissue blocks available for our analysis using in ...

show abstract

“…[47][48][49][50] Esophageal cancer (squamous cell carcinoma) has been positively associated with HPV, with a stronger association in high-risk populations, [51][52][53][54][55] but contradictory results have been reported. 56 Cigarette smoking is considered as the most important factor in the etiology of lung cancer, but detection of circulating HPV DNA in blood samples has been suggested as a risk marker for lung cancer, 57 and play a role in the carcinogenesis of lung cancer. 58 However, all studies do not point in the same direction.…”

Section: Discussionmentioning

confidence: 99%

Cancer risk among patients with condylomata acuminata

Nordenvall

Chang

Adami

et al. 2006

Intl Journal of Cancer

View full text Add to dashboard Cite

Condylomata acuminata have been shown to increase the risk of anogenital cancers. However, previous studies have been of limited sample size and/or short follow-up duration, which prevent precise estimates of long-term excess risk, especially for specific cancer sites. We estimated the risk of specific cancers in a large cohort of hospitalized patients with condylomata acuminata, as recorded in the Swedish Inpatient Register between 1965 and 1999. Altogether, 10,971 patients (1,685 men and 9,286 women) were followed through 1999 for a median of 13 years. The standardized incidence ratio (SIR)-the ratio of the observed number of cancers to the number expected on the basis of the incidence in the Swedish population at large-was used as a measure of relative risk. After excluding the first-year of follow-up, we observed 43 cases of anogenital cancer in women, and 7 cases in men. Risks were elevated for cancers of the vulva (N 5 13, SIR 5 10.2, 95% confidence interval (CI) 5 5.4-17.4), vagina (N 5 4, SIR 5 12.0, 95% CI 5 3.3-30.7) and penis (N 5 5, SIR 5 21.9, 95% CI 5 7.1-51.2). There was a moderate excess risk of cervical cancer in situ (N 5 259, SIR 5 1.9, 95% CI 5 1.7-2.1), but not invasive cervical cancer. Excess risks of esophageal, buccal cavity, nonmelanoma skin, lung and bladder cancers, and Hodgkin and non-Hodgkin lymphoma, were also observed in both men and women. In conclusion, condylomata acuminata are strongly associated with increased risk of cancers of the vulva, vagina, penis and anus, as well as some nonanogenital malignancies, but not invasive cervical cancer. ' 2006 Wiley-Liss, Inc.

show abstract

The presence of human papillomavirus type 16/18 DNA in blood circulation may act as a risk marker of lung cancer in Taiwan

Cited by 72 publications

References 12 publications

Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile

Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile

Assessment of human papillomavirus and Epstein-Barr virus in lung adenocarcinoma

Cancer risk among patients with condylomata acuminata

Contact Info

Product

Resources

About