1981
DOI: 10.1007/bf00332357
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The presence of intranuclear lipid inclusions in hepatocytes of mice after chronic ingestion of polybrominated biphenyl

Abstract: Electron microscopic study of livers from mice fed 167 ppm polybrominated biphenyl (PBB) for 12 weeks showed hepatocytes with nuclei containing varied amounts of lipid inclusions. The inclusions appeared as spherical vacuoles free in the nuclear matrix. This is the first report of the induction of lipid inclusions within the nucleus by a halogenated hydrocarbon.

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Cited by 4 publications
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“…Those LDs might be actually located in cytoplasmic invaginations deep into the nucleus, but electron microscopic (EM) studies that followed demonstrated that LDs were present within the nucleoplasm. The EM studies revealed LDs in four situations: (i) the nucleolus of rat liver cells during thioacetamide-induced carcinogenesis (Thoenes, 1964), (ii) LDs in the nucleoplasm and in the lumen of the endoplasmic reticulum (ER)/nuclear envelope/NR in rat liver treated with carcinogenic N, N 0 -dimethyl-4-aminoazobenzene (Karasaki, 1969(Karasaki, , 1973, (iii) nuclear LDs in mouse liver treated with hepatotoxic polybrominated biphenyl (Martino et al, 1981), and (iv) nuclear LDs in mouse embryonic cells with lethal mutations (Hillman et al, 1970;Hillman and Hillman, 1975).…”
Section: Early Studiesmentioning
confidence: 99%
“…Those LDs might be actually located in cytoplasmic invaginations deep into the nucleus, but electron microscopic (EM) studies that followed demonstrated that LDs were present within the nucleoplasm. The EM studies revealed LDs in four situations: (i) the nucleolus of rat liver cells during thioacetamide-induced carcinogenesis (Thoenes, 1964), (ii) LDs in the nucleoplasm and in the lumen of the endoplasmic reticulum (ER)/nuclear envelope/NR in rat liver treated with carcinogenic N, N 0 -dimethyl-4-aminoazobenzene (Karasaki, 1969(Karasaki, , 1973, (iii) nuclear LDs in mouse liver treated with hepatotoxic polybrominated biphenyl (Martino et al, 1981), and (iv) nuclear LDs in mouse embryonic cells with lethal mutations (Hillman et al, 1970;Hillman and Hillman, 1975).…”
Section: Early Studiesmentioning
confidence: 99%