The presence of ochratoxin A in cord serum and in human milk and its correspondence with maternal dietary habits

Biasucci, Giacomo; Calabrese, G.; Giuseppe, Romina di; Carrara, G; Colombo, Francesca; Mandelli, B; Maj, M.; Bertuzzi, Terenzio; Pietri, Amedeo; Rossi, Filippo

doi:10.1007/s00394-010-0130-y

Cited by 75 publications

(46 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The result of a similar study in Egypt indicated that from a total 120 human milk samples, OTA was found in 43 (35.8%) of the samples (22). In addition, the mean concentration of the toxin in this study was higher than that of the previous studies, such as 17.5 ng/L in Brazil (12), 10-57 ng/L in Italy (23,24), and 17-30 ng/L in Germany (16), while lower amounts such 8.87 ng/L was noticed in Egypt (25), 106 ng/L in Chile (26), 39.8 ng/L in Norway (27), and 7900 ng/L in Sierra Leone (28). …”

Section: Discussioncontrasting

confidence: 83%

“…For instance, Nordic Working Group has suggested the highest daily TDI of OTA level in human's body as 5 ng/kg of baby weight (30). Recently, based on the regulations made by the European Union's cooperating with European Food Safety Authority (EFSA), the tolerable weekly intake of OTA has been reported as 120 ng/kg body weight and TDI of 20 ng has been suggested for the children (23). …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Ochratoxin A in Human Milk in the Khorrambid Town, Fars Province, South of Iran

Dehghan

Pakshir

Rafiei

et al. 2014

Jundishapur J Microbiol

View full text Add to dashboard Cite

Background:Ochratoxins belong to a group of mycotoxins produced as the secondary metabolites by filamentous fungi, such as Aspergillus and Penicillium. These toxins may be teratogenic, mutagenic, hepatotoxic, nephrotoxic, and may have immunosuppressive effects and pose a serious health problems to exposed humans and animals.Objectives:The present study aimed to determine the level of ochratoxin A (OTA) in the samples of mothers' milk in the Khorrambid Town, Fars Province, south of Iran.Materials and Methods:Between June and July 2011, samples of human milk were obtained from 87 mothers. The samples were diluted by absolute methanol at 1:4 ratio and after centrifugation, the supernatant was directly used to determine the level of OTA using competitive enzyme-linked immunosorbent assay (ELISA).Results:Among 87 human milk samples, 84 (96.6%) samples had positive results for OTA at a mean level of 24.57 ± 13.6 ng/L. According to the European Union Standard, 14 (16%) positive samples revealed more than the maximum limit of 40 ng/L for ochratoxin (range, 1.6-60 ng/L).Conclusions:Presence of OTA in the milk of mothers denotes a probable consumption of a contaminated foods. Therefore, regular monitoring of foods for presence of mycotoxins for lactating mothers seems necessary.

show abstract

Section: Discussioncontrasting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Prevalence of Ochratoxin A in Human Milk in the Khorrambid Town, Fars Province, South of Iran

Dehghan

Pakshir

Rafiei

et al. 2014

Jundishapur J Microbiol

View full text Add to dashboard Cite

show abstract

“…As a widespread food contaminant, OTA was found in human blood [26,27], milk [28], and urine [29,30,31]. This mycotoxin has several effects on animal and human health.…”

Section: Ochratoxin Amentioning

confidence: 99%

Aptamers: A Promising Tool for Ochratoxin A Detection in Food Analysis

Rhouati

Yang

Hayat

et al. 2013

Toxins

118

View full text Add to dashboard Cite

The contamination of food and feed by mycotoxins has become an increasingly serious problem. Mycotoxins represent a major risk to human and animal health, as well as economics. Herein, we focus on Ochratoxin A (OTA), which is one of the most common mycotoxins contaminating feed and foodstuffs. OTA is a secondary metabolite produced by various Aspergillus and Penicillium strains. Upon ingestion, OTA has a number of acute and chronic toxic effects. It is nephrotoxic, teratogenic, immunosuppressive, and carcinogenic (group 2B). As a consequence, some regulatory limits have been introduced on the levels of OTA in several commodities. The toxic nature of OTA demands highly sensitive and selective monitoring techniques to protect human and animal health. As alternative to traditional analytical techniques, biochemical methods for OTA analysis have attained great interest in the last few decades. They are mainly based on the integration of antibodies or aptamers as biorecognition elements in sensing platforms. However, aptamers have gained more attention in affinity-based assays because of their high affinity, specificity, stability, and their easy chemical synthesis. In this brief review, we present an overview of aptamer-based assays and their applications in OTA purification and detection, appeared in the literature in the last five years.

show abstract

“…OTA is found to be absorbed through gastrointestinal tract and lungs of rat with high efficiency (Breitholtz-Emanuelsson, Fuchs, & Hult, 1995;Kumagai & Aibara, 1982) and shows strong binding to albumin of blood thereby ensuring the prolonged biological half-life (Scott, 2005). It is established that OTA is continuously and unavoidably being ingested with food as its detection in human plasma, serum, blood, breast milk and urine of people from many countries have been reported (Biasucci et al, 2011;Coronel et al, 2011;Coronel, Sanchis, Ramos, & Marin, 2010). Consequently, the European Union Scientific Committee for Human Feeding deemed necessary to take prudential measures in order to set a maximum permissible level of 5 mg kg À1 (5 ppb) in raw wheat, barley and rye (European Commission, 2005).…”

Section: Introductionmentioning

confidence: 98%

Detection of Ochratoxin A in wheat samples in different regions of India

et al. 2012

View full text Add to dashboard Cite

The presence of ochratoxin A in cord serum and in human milk and its correspondence with maternal dietary habits

Abstract: This study confirms that OTA is widely present in human milk and therefore could pose a risk for the newborn.

Cited by 75 publications

References 25 publications

Prevalence of Ochratoxin A in Human Milk in the Khorrambid Town, Fars Province, South of Iran

Prevalence of Ochratoxin A in Human Milk in the Khorrambid Town, Fars Province, South of Iran

Aptamers: A Promising Tool for Ochratoxin A Detection in Food Analysis

Detection of Ochratoxin A in wheat samples in different regions of India

Contact Info

Product

Resources

About