The presence of polystyrene nanoplastics enhances the MCLR uptake in zebrafish leading to the exacerbation of oxidative liver damage

Ling, Xiaodong; Zuo, Junli; Pan, Meiqi; Nie, Hongyan; Shen, Jianzhong; Yang, Qing; Hung, Tien‐Chieh; Li, Guangyu

doi:10.1016/j.scitotenv.2021.151749

Cited by 21 publications

(2 citation statements)

References 109 publications

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“…Yu et al demonstrated that co-exposure of PSNPs and oxytetracycline (antibiotic), promoted the internalization of oxytetracycline, enhancing the toxicity effects (intestinal damage) in zebrafish [119]. PSNPs were also reported to promote accumulation of microcystin-LR (toxins) in the liver of zebrafish [139].…”

Section: Mnp Uptake By Animalsmentioning

confidence: 99%

Plastics and Micro/Nano-Plastics (MNPs) in the Environment: Occurrence, Impact, and Toxicity

Dube,

Okuthe

2023

IJERPH

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Plastics, due to their varied properties, find use in different sectors such as agriculture, packaging, pharmaceuticals, textiles, and construction, to mention a few. Excessive use of plastics results in a lot of plastic waste buildup. Poorly managed plastic waste (as shown by heaps of plastic waste on dumpsites, in free spaces, along roads, and in marine systems) and the plastic in landfills, are just a fraction of the plastic waste in the environment. A complete picture should include the micro and nano-plastics (MNPs) in the hydrosphere, biosphere, lithosphere, and atmosphere, as the current extreme weather conditions (which are effects of climate change), wear and tear, and other factors promote MNP formation. MNPs pose a threat to the environment more than their pristine counterparts. This review highlights the entry and occurrence of primary and secondary MNPs in the soil, water and air, together with their aging. Furthermore, the uptake and internalization, by plants, animals, and humans are discussed, together with their toxicity effects. Finally, the future perspective and conclusion are given. The material utilized in this work was acquired from published articles and the internet using keywords such as plastic waste, degradation, microplastic, aging, internalization, and toxicity.

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Section: Mnp Uptake By Animalsmentioning

confidence: 99%

Plastics and Micro/Nano-Plastics (MNPs) in the Environment: Occurrence, Impact, and Toxicity

Dube,

Okuthe

2023

IJERPH

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“… 42 Moreover, MNPs can serve as vectors for the internalization of secondary pollutants. 43 , 44 Given the ubiquitous presence of MNPs in cosmetics 45 and in the aquatic environment, 4 the presence of MNPs may complicate the biological actions of HMS. Therefore, further studies are urgently needed to investigate the impact of MNPs on the toxicity of HMS, particularly in relation to its estrogenic effects.…”

Section: Introductionmentioning

confidence: 99%

Combined Effects of Polystyrene Nanosphere and Homosolate Exposures on Estrogenic End Points in MCF-7 Cells and Zebrafish

Ye,

Li,

Xian

et al. 2024

Environ Health Perspect

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Background: Micro- and nanoplastics (MNPs) and homosalate (HMS) are ubiquitous emerging environmental contaminants detected in human samples. Despite the well-established endocrine-disrupting effects (EDEs) of HMS, the interaction between MNPs and HMS and its impact on HMS-induced EDEs remain unclear. Objectives: This study aimed to investigate the influence of MNPs on HMS-induced estrogenic effects and elucidate the underlying mechanisms in vitro and in vivo . Methods: We assessed the impact of polystyrene nanospheres (PNSs; , ) on HMS-induced MCF-7 cell proliferation (HMS: , equivalent to ) using the E-SCREEN assay and explored potential mechanisms through transcriptomics. Adult zebrafish were exposed to HMS ( ) with or without PNSs ( , ) for 21 d. EDEs were evaluated through gonadal histopathology, fertility tests, steroid hormone synthesis, and gene expression changes in the hypothalamus–pituitary–gonad–liver (HPGL) axis. Results: Coexposure of HMS and PNSs resulted in higher expression of estrogen receptor ( ESR1 ) and the mRNAs of target genes ( pS2 , AREG , and PGR ), a greater estrogen-responsive element transactivation activity, and synergistic stimulation on MCF-7 cell proliferation. Knockdown of serum and glucocorticoid-regulated kinase 1 (SGK1) rescued the MCF-7 cell proliferation induced by PNSs alone or in combination with HMS. In zebrafish, coexposure showed higher expression of SGK1 and promoted ovary development but inhibited spermatogenesis. In addition, coexposure led to lower egg hatchability, higher embryonic mortality, and greater larval malformation. Coexposure also modulated steroid hormone synthesis genes ( cyp17a2 , hsd17 1 , esr2b , vtg1 , and vtg2 ), and resulted in higher ( ) release in females. Conversely, males showed lower testosterone, , and gene expressions of cyp11a1 , cyp11a2 , cyp17a1 , cyp17a2 , and hsd17 1 . Discussion: PNS exposure exacerbated HMS-induced estrogenic effects via SGK1 up-regulation in MCF-7 cells and disrupting the HPGL axis in zebrafish, with gender-specific patterns. This offers new mechanistic insights and health implications of MNP and contaminant coexposure. https://doi.org/10.1289/EHP13696

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Combined effects of cadmium and nanoplastics on oxidative stress, histopathology, and intestinal microbiota in largemouth bass (Micropterus salmoides)

et al. 2023

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The presence of polystyrene nanoplastics enhances the MCLR uptake in zebrafish leading to the exacerbation of oxidative liver damage

Cited by 21 publications

References 109 publications

Plastics and Micro/Nano-Plastics (MNPs) in the Environment: Occurrence, Impact, and Toxicity

Plastics and Micro/Nano-Plastics (MNPs) in the Environment: Occurrence, Impact, and Toxicity

Combined Effects of Polystyrene Nanosphere and Homosolate Exposures on Estrogenic End Points in MCF-7 Cells and Zebrafish

Combined effects of cadmium and nanoplastics on oxidative stress, histopathology, and intestinal microbiota in largemouth bass (Micropterus salmoides)

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