The presence of positive surgical margins in patients with organ-confined prostate cancer results in biochemical recurrence at a similar rate to that in patients with extracapsular extension and PSA≤10ng/ml

Eminaga, Okyaz; Hinkelammert, Reemt; Titze, Ulf; Abbas, Mahmoud; Eltze, Elke; Bettendorf, Olaf; Semjonow, Axel

doi:10.1016/j.urolonc.2012.11.021

Cited by 9 publications

(14 citation statements)

References 31 publications

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“…Most previous studies found that a PSM was a prognostic parameter for postoperative BCR or disease progression of PCa [5,10-12,14,15,17,19]. In contrast with the above studies, several other studies demonstrated that a PSM was not associated with BCR or disease progression [20,21].…”

Section: Discussionmentioning

confidence: 95%

Do Positive Surgical Margins Predict Biochemical Recurrence in All Patients Without Adjuvant Therapy After Radical Prostatectomy?

et al. 2013

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PurposeThe objective was to study whether positive surgical margins (PSMs) predict biochemical recurrence (BCR) in all patients without adjuvant therapy after radical prostatectomy (RP).Materials and MethodsWe retrospectively reviewed the medical records of patients who underwent RP for prostate cancer at Veterans Health Service Medical Center from 2005 to 2011. BCR was defined by a prostate-specific antigen (PSA) value ≥0.2 ng/mL. The clinicopathological factors of the PSM group were compared with those of the negative surgical margin (NSM) group, and the predictive impact of a PSM for BCR-free survival were evaluated. In addition, we analyzed the prognostic difference for BCR-free survival between solitary and multiple PSMs.ResultsA PSM was noted in 167 patients (45.5%). BCR was reported in 101 men in total (27.5%). The BCR-free survival rate of the PSM group was lower than that of the NSM group (p<0.001). In a multivariate analysis for the total patients, PSM was significantly associated with BCR-free survival (p<0.001). After stratification by pathological T stage, Gleason score (GS), and preoperative PSA value, PSM was significantly predictive for BCR-free survival in men with pT2 and/or GS ≤6 or 7 and/or a PSA value <10 or 10-20 ng/mL (all p<0.05). Multiple PSMs were more predictive of BCR-free survival than was a solitary PSM (p=0.001).ConclusionsA PSM is a significant predictor of postoperative BCR in patients with pT2 and/or GS ≤7 and/or preoperative PSA <20 ng/mL. Multiple PSMs are considered a stronger prognostic factor for prediction of BCR than is a solitary PSM.

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Section: Discussionmentioning

confidence: 95%

Do Positive Surgical Margins Predict Biochemical Recurrence in All Patients Without Adjuvant Therapy After Radical Prostatectomy?

et al. 2013

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“…Eminaga et al [27] also investigated the BCR in patients with organ-confined prostate cancer and PSM in a RP series from 1999 to 2008. They divided the patients into 5 groups according to pathological category, PSM, and PSA level: pT2 category without PSM, pT2þ category, pT3a category and PSA r 10 ng/ml, pT3a category and PSA 4 10 ng/ml, and pT3b category.…”

Section: Discussionmentioning

confidence: 99%

Clinical effect of a positive surgical margin without extraprostatic extension after robot-assisted radical prostatectomy

Hashimoto

Yoshioka

Horiguchi

et al. 2015

Urologic Oncology: Seminars and Original Investigations

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“…While many studies have examined pathological features and the risk of BCR [9][10][11][12][13][14][15][16][17], to our knowledge, only two studies [18,19] have directly compared combinations of pathological features as risk factors for BCR and survival outcomes among men with pathological Gleason score 8-10 disease at the time of RP. That said, these studies are >10 years old, and did not examine a heterogeneous cohort of men, whereas in the present study cohort, selected from the SEARCH database, 30% of the men were black.…”

Section: Discussionmentioning

confidence: 99%

“…Not all men with Gleason score 8-10 disease, however, are destined to experience BCR. When assessing risk of recurrence after RP, many studies consider pathological features, either individually, as pathological stage, or in various 'favourable' or 'unfavourable' groupings, as risk factors for BCR or other endpoints, such as prostate cancerspecific survival [5,[8][9][10][11][12][13][14][15][16][17], but while previous studies have examined the relationship between pathological features and BCR in pathological high grade disease [18,19], these studies are >10 years old and, to our knowledge, have not been updated to examine a more racially heterogeneous cohort of men. We therefore used the SEARCH database of men treated with RP [20] to identify men with pathological high grade disease (Gleason score [8][9][10] and to create groups based on various combinations of pathological features and compare these groups with regard to BCR risk.…”

Section: Introductionmentioning

confidence: 99%

Do all men with pathological Gleason score 8–10 prostate cancer have poor outcomes? Results from the SEARCH database

et al. 2015

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ObjectiveTo determine whether there are subsets of men with pathological high grade prostate cancer (Gleason score 8-10) with particularly high or low 2-year biochemical recurrence (BCR) risk after radical prostatectomy (RP) when stratified into groups based on combinations of pathological features, such as surgical margin status, extracapsular extension (ECE) and seminal vesicle invasion (SVI). Materials and MethodsWe identified 459 men treated with RP with pathological Gleason score 8-10 prostate cancer in the SEARCH database. The men were stratified into five groups based on pathological characteristics: group 1, men with negative surgical margins (NSMs) and no ECE; group 2, men with positive surgical margin (PSMs) and no ECE; group 3, men with NSMs and ECE; group 4, men with PSMs and ECE; and group 5, men with SVI. Cox proportional hazards models and the log-rank test were used to compare BCR among the groups.

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The presence of positive surgical margins in patients with organ-confined prostate cancer results in biochemical recurrence at a similar rate to that in patients with extracapsular extension and PSA≤10ng/ml

Cited by 9 publications

References 31 publications

Do Positive Surgical Margins Predict Biochemical Recurrence in All Patients Without Adjuvant Therapy After Radical Prostatectomy?

Do Positive Surgical Margins Predict Biochemical Recurrence in All Patients Without Adjuvant Therapy After Radical Prostatectomy?

Clinical effect of a positive surgical margin without extraprostatic extension after robot-assisted radical prostatectomy

Do all men with pathological Gleason score 8–10 prostate cancer have poor outcomes? Results from the SEARCH database

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