The Presence of Spermatozoa in the Semen of Vasectomized Men

M, Freund; Couture, Margaret

doi:10.1002/j.1939-4640.1982.tb00690.x

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…It appears that the ligated vas deferens is capable of generating new channels that, in some cases, may reconnect the two severed ends of the duct, permitting the passage of sperm from the epididymis into the ejaculate semen. This unusual phenomenon is called "recanalization" or micror re canalization^' (Civantos et al, 1972;Freund and Couture, 1982;Hayashi et al, 1983;Cruickshank et al, 1987;Freund et al, 1989).…”

Section: Occlusion Carbendazim Ratmentioning

confidence: 97%

Epithelial reorganization and irregular growth following carbendazim‐induced injury of the efferent ductules of the rat testis

1993

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Occlusions of the rat efferent ductules were induced by an oral gavage of carbendazim and the capacity for regeneration or recanalization of the ductules was histologically evaluated between 2 and 70 days post-treatment. At 2 days post-treatment, the efferent ductules were occluded by sloughed materials and showed various degrees of inflammation. Severely damaged epithelium showed few regenerative features at later intervals. On the other hand, epithelia with medium inflammation often exhibited irregular epithelial growth along the luminal contents or the formation of multiple abnormal ductules. These abnormal ductules were formed by migrated and original epithelia at the periphery of the occluded lumen at 16 days post-treatment, indicating attempted recanalization. At later time periods, 32 and 70 days post-treatment, the occluded original lumen was filled in by fibrotic connective tissue and surrounded by a series of abnormal ductules. These abnormal ductules were characterized by cuboidal epithelia, a small luminal diameter, fewer cilitated cells than normal, less developed organelles in the epithelial cells, and basal laminae of irregular thickness. However, there was no evidence that occluded ductules formed patent re-connections via abnormal ductules. The results suggest that occluded efferent ductules have the ability to initiate epithelial regrowth and to form new ductules, but the newly formed ductules are abnormal and are not adequate to recover from azoospermia at least at 70 days post-treatment.

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Section: Occlusion Carbendazim Ratmentioning

confidence: 97%

Epithelial reorganization and irregular growth following carbendazim‐induced injury of the efferent ductules of the rat testis

1993

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Microrecanalization After Vasectomy in Man

Freund¹,

Weidmann²,

Goldstein

et al. 1989

Journal of Andrology

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Previously spermatozoa in the semen of vasectomized men were reported in 62 of 63 specimens from 24 men 2 to 31 years postvasectomy (Freund and Couture, 1982). A morphologic basis and term, "microrecanalization," was proposed for this observation. Serial sections (5 mu at 200-mu intervals) of 40 specimens removed at vasovasostomy from 20 men (2 to 14 years postvasectomy) were examined and microcanals (small epithelial-lined channels) were demonstrated in 27 specimens from 18 men. In nine of the 27 specimens, spermatozoa or sperm heads were found within the microcanals. Microcanals occurred in smooth muscle, connective tissue and scar tissue, in each segment, testicular, central and abdominal, in the presence or absence of the vas deferens. Microcanal continuity was traced for 200 to 1140 microns by computerized image analysis. Microrecanalization is characterized by the absence of inflammation or sperm extravasation and is histologically distinct from vasitis nodes or sperm granuloma. Microrecanalization provides morphologic and physiologic bases for the protection of the testis and maintenance of spermatogenesis in man after vasectomy.

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Vasectomy

Pan¹,

Honig²

2018

Encyclopedia of Reproduction

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The Presence of Spermatozoa in the Semen of Vasectomized Men

Cited by 5 publications

References 12 publications

Epithelial reorganization and irregular growth following carbendazim‐induced injury of the efferent ductules of the rat testis

Epithelial reorganization and irregular growth following carbendazim‐induced injury of the efferent ductules of the rat testis

Microrecanalization After Vasectomy in Man

Vasectomy

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