The presence of synchronized perfusion dips in the microcirculation of the resting nail bed

Mirdell, Robin; Lemstra-Idsardi, Aukje Nienke; Farnebo, Simon; Tesselaar, Erik

doi:10.1016/j.mvr.2018.10.004

Cited by 7 publications

(4 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To be clinically relevant, assessment of cutaneous blood flow must be able to distinguish nutritional blood flow from AVA-dependent flow. Approaches such as thermography, laser Doppler imaging lack that resolution, and laser speckle contrast imaging can also be impacted by AVA flow [117][118][119]. Restricting analysis to dorsal surfaces, with their reduced AVA density, is not devoid of AVA interference, which may reflect extensive connections between palmer and dorsal circulations.…”

Section: Vascular Stabilization As Vascular Therapymentioning

confidence: 99%

New mechanism-based approaches to treating and evaluating the vasculopathy of scleroderma

Flavahan

2021

Current Opinion in Rheumatology

View full text Add to dashboard Cite

Purpose of reviewUtilizing recent insight into the vasculopathy of scleroderma (SSc), the review will highlight new opportunities for evaluating and treating the disease by promoting stabilization and protection of the microvasculature.Recent findingsEndothelial junctional signaling initiated by vascular endothelial-cadherin (VE-cadherin) and Tie2 receptors, which are fundamental to promoting vascular health and stability, are disrupted in SSc. This would be expected to not only diminish their protective activity, but also increase pathological processes that are normally restrained by these signaling mediators, resulting in pathological changes in vascular function and structure. Indeed, key features of SSc vasculopathy, from the earliest signs of edema and puffy fingers to pathological disruption of hemodynamics, nutritional blood flow, capillary structure and angiogenesis are all consistent with this altered endothelial signaling. It also likely contributes to further progression of the disease including tissue fibrosis, and organ and tissue injury.SummaryRestoring protective endothelial junctional signaling should combat the vasculopathy of SSc and prevent further deterioration in vascular and organ function. Indeed, this type of targeted approach has achieved remarkable results in preclinical models for other diseases. Furthermore, tracking this endothelial junctional signaling, for example by assessing vascular permeability, should facilitate insight into disease progression and its response to therapy.

show abstract

Section: Vascular Stabilization As Vascular Therapymentioning

confidence: 99%

New mechanism-based approaches to treating and evaluating the vasculopathy of scleroderma

Flavahan

2021

Current Opinion in Rheumatology

View full text Add to dashboard Cite

show abstract

“…29,30 Sympathetic blocks with local anesthetic may improve tissue perfusion as well. [31][32][33] Vascular studies such as duplex or CTA may be valuable at this time as well. If it is possible to decrease the dose of vasopressors without putting the patient at risk, then vasopressors ought to be titrated down.…”

Section: Discussionmentioning

confidence: 99%

Management of vasopressor induced ischemia

Livesey

Jauregui

Hamaker

et al. 2020

Journal of Orthopaedics

View full text Add to dashboard Cite

“…The dip detection algorithm is presented alongside the raw perfusion data. For a discussion about the different parts of the formulas, please see the original article [1] .…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Data on microcirculatory perfusion dips in the resting nail bed

et al. 2018

Self Cite

View full text Add to dashboard Cite

This article contains the raw data from the article entitled: “The presence of synchronized perfusion dips in the microcirculation of the resting nail bed” Mirdell et al. (in press). A laser speckle contrast imager (LSCI) was used to make a total of 21 recordings of the perfusion in the resting nail bed of 10 healthy test subjects. The first 10 recordings were acquired after 5 min of acclimatization. An additional 10 recordings were acquired in the same test subjects, after 20 min of acclimatization. In the last recording, a digital nerve block was applied to the left dig III. The data show the presence of highly irregular perfusion variations, a phenomenon we like to call perfusion dips. The data also show how the perfusion dips can be abolished through a digital nerve block. An algorithm for the quantification of the perfusion dips is included in the data.

show abstract

The presence of synchronized perfusion dips in the microcirculation of the resting nail bed

Cited by 7 publications

References 34 publications

New mechanism-based approaches to treating and evaluating the vasculopathy of scleroderma

New mechanism-based approaches to treating and evaluating the vasculopathy of scleroderma

Management of vasopressor induced ischemia

Data on microcirculatory perfusion dips in the resting nail bed

Contact Info

Product

Resources

About