The presence of thyroid peroxidase antibody of IgG2 subclass is a risk factor for thyroid dysfunction in chronic hepatitis C patients

Abstract

Objective: To investigate the prevalence of thyroid dysfunction (TD) and IgG subclasses of thyroid autoantibodies (TAs) and to determine the predictive factors of TD in chronic hepatitis C (CHC) patients. Design: Three hundred and twelve untreated hepatitis C virus-infected patients without a history of TD or treatment with thyroid hormones were enrolled in a cross-sectional study. Clinical and biological factors were statistically analyzed to determine the correlation between TD and this patient population. Results: The incidence of TD was 12.5% in CHC patients. Clinical hypothyroidism (5.8%) and subclinical hypothyroidism (3.8%) were more frequent than clinical hyperthyroidism (1.6%) and subclinical hyperthyroidism (1.3%). The percentage of TA-positive patients was significantly higher in people O60 years than in those %60 years (31.9 vs 18.6%; PZ0.042). Positive thyroid peroxidase antibody (TPOAb) was more frequent, and alanine aminotransferase (ALT) levels were lower in patients who displayed TD (TPOAb: 62.1 vs 10.8%, PZ0.000; ALT: 43.5 vs 51 IU/l, PZ0.046). The positive percentage of TPOAb IgG2 subclass in the TD group was significantly higher than that of patients without TD (66.7 vs 16.7%, PZ0.005). Multiple logistic regression analysis indicated that only TPOAb IgG2 subclass positivity was an independent risk factor for TD in CHC patients (odds ratioZ8; 95% CI: 1.225-52.246; PZ0.030). Conclusions: TPOAb IgG2 subclass positivity is a risk factor for TD in CHC patients before antiviral treatment. IgG2 subclass of TPOAb might play an important role in the presence of TD in CHC patients.

Thyroid Dysfunction in Non-Interferon Treated Hepatitis C Patients Residing in Hepatitis Endemic Area

“…According to our results, though overall incidence of TD was much higher than general population, pattern of relatively more hypothyroidism (9.0%) than hyperthyroidism (6.3%) was observed in HCV patients. This result is in accordance with other studies in which higher incidence of hypothyroidism as compared to hyperthyroidism is reported in HCV patients [15, 17]. According to a recent meta-analysis HCV patients are three times more prone to hypothyroidism as compared to control subjects [21].…”

“…Our results showed that thyroid dysfunction was detected in 15.2% of the HCV patients. This figure is in accordance with studies carried out in other countries reporting thyroid dysfunction in 7% to 15% untreated HCV patients [6–8, 17]. A recent review of such studies reported 10–15% frequency of TD in interferon-free HCV patients [18].…”

Thyroid Disease and Oral Lichen Planus as Comorbidity: A Prospective Case-Control Study

“…These diseases have confirmed an increased prevalence among patients with thyroid disorders [5,6,7,8,9]. Based on the immunological pathogenesis of OLP, previous research has shown the presence of serum antibodies to thyroglobulin and thyroid microsomal antibodies in OLP patients [10,11].…”