The Present Position of Sulphonamide Therapy

Many clinicians are utilizing a 2-g loading dose of sulfisoxazole in the treatment of uncomplicated urinary tract infection. Although some of these clinicians understand the theoretical reasons for not utilizing such a treatment plan, they may be reluctant to depart from the official recommendations for sulfisoxazole because of the lack of supporting clinical data. The findings of this study provide support for the theoretical considerations outlined previously. Also, considering the potential disadvantages of the loading dose employment, for example, source of patient misunderstanding and complicated patient instructions data supporting the omission of a sulfisoxazole loading dose should be most welcome. In conclusion, the study results suggest that the inclusion of a 2-g loading dose of sulfisoxazole in the treatment of this sample of acute, uncomplicated urinary tract infections did not offer any therapeutic benefit.

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President’s Message / Committee on Dental Preparedness / Bureau of Public Relations / Council on Dental Therapeutics / Council on Dental Education / Committee on Legislation / Committee on Economics / News Items / American Dental Association

Ostrander

Hartmann

Hughes³

et al. 1942

The Journal of the American Dental Association

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The Present Position of Sulphonamide Therapy

Cited by 3 publications

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An investigation into the value of sulphapyridine in the treatment of pulmonary tuberculosis

An investigation into the value of sulphapyridine in the treatment of pulmonary tuberculosis

Comparative Trial of Two Sulfisoxazole Regimens in Acute Urinary Tract Infection

President’s Message / Committee on Dental Preparedness / Bureau of Public Relations / Council on Dental Therapeutics / Council on Dental Education / Committee on Legislation / Committee on Economics / News Items / American Dental Association

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